Maternal and Umbilical Cord Heat-Shock Protein 70 Levels in Patients with Gestational Diabetes Mellitus

Mete Bertizlioğlu; Setenay Yılmaz; Ayşegül Kebapçılar; Aybike Tazegul; Özlem Seçilmiş; Berat Berrin Gençoğlu Bakbak; Sedat Abuşoğlu; Cetin Celik; Ali Unlu; Nasuh Utku Doğan; Görkem Aktaş

Article Details

Maternal and Umbilical Cord Heat-Shock Protein 70 Levels in Patients with Gestational Diabetes Mellitus

Authors:

Mete Bertizlioğlu | Setenay Yılmaz | Ayşegül Kebapçılar | Aybike Tazegul | Özlem Seçilmiş | Berat Berrin Gençoğlu Bakbak | Sedat Abuşoğlu | Cetin Celik | Ali Unlu | Nasuh Utku Doğan | Görkem Aktaş

Publisher:

Selcuk University

Main Topics:

Klinik Tıp Bilimleri (Diğer)

Journal:

Genel Tıp Dergisi Vol.34 Issue 2, pp.251-257

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001316109

pISSN:

2602-3741

Keywords:

Abstract:

 AIMS: The purpose of this study is to determine if heat shock protein 70 Hsp-70, a marker of cellular stress, is elevated in maternal serum and umbilical cord in pregnancies complicated by gestational diabetes mellitus GDM and to determine whether altered serum Hsp-70 concentrations in umbilical cord are related to serve as an indicator of early term delivery 37 0738 67 weeks of gestation in women with GDM and control group. METHODS: The study included 62 patients with GDM GDM group and 22 non-diabetic, healthy women before caesarean section in this case-control study. We analyzed serum levels of Hsp-70 in pregnancies and umbilical cord sera and other biochemical and anthropometric markers, early term delivery in all subjects. RESULTS: Maternal Serum levels of Hsp-70 were significantly higher in patients with GDM than in healthy pregnant women. The umbilical cord levels of Hsp-70 in GDM patients were also increased as compared to healthy pregnant women but missed the commonly acceptable significance level. Cord Hsp-70 levels showed a negatively significant correlation with time of delivery, in women with GDM patients. Cord Hsp-70 levels showed a negatively significant correlation with time of delivery, also in the whole group. CONCLUSIONS: Maternal Hsp-70 was significantly higher in patients with GDM. The obtained results seem to indicate that elevated umbilical cord Hsp-70 values may potentially be used as indicators of risk factor for early term delivery in pregnancies.

 AIMS: The purpose of this study is to determine if heat shock protein 70 Hsp-70, a marker of cellular stress, is elevated in maternal serum and umbilical cord in pregnancies complicated by gestational diabetes mellitus GDM and to determine whether altered serum Hsp-70 concentrations in umbilical cord are related to serve as an indicator of early term delivery 37 0738 67 weeks of gestation in women with GDM and control group. METHODS: The study included 62 patients with GDM GDM group and 22 non-diabetic, healthy women before caesarean section in this case-control study. We analyzed serum levels of Hsp-70 in pregnancies and umbilical cord sera and other biochemical and anthropometric markers, early term delivery in all subjects. RESULTS: Maternal Serum levels of Hsp-70 were significantly higher in patients with GDM than in healthy pregnant women. The umbilical cord levels of Hsp-70 in GDM patients were also increased as compared to healthy pregnant women but missed the commonly acceptable significance level. Cord Hsp-70 levels showed a negatively significant correlation with time of delivery, in women with GDM patients. Cord Hsp-70 levels showed a negatively significant correlation with time of delivery, also in the whole group. CONCLUSIONS: Maternal Hsp-70 was significantly higher in patients with GDM. The obtained results seem to indicate that elevated umbilical cord Hsp-70 values may potentially be used as indicators of risk factor for early term delivery in pregnancies.

 AIMS: The purpose of this study is to determine if heat shock protein 70 Hsp-70, a marker of cellular stress, is elevated in maternal serum and umbilical cord in pregnancies complicated by gestational diabetes mellitus GDM and to determine whether altered serum Hsp-70 concentrations in umbilical cord are related to serve as an indicator of early term delivery 37 0738 67 weeks of gestation in women with GDM and control group. METHODS: The study included 62 patients with GDM GDM group and 22 non-diabetic, healthy women before caesarean section in this case-control study. We analyzed serum levels of Hsp-70 in pregnancies and umbilical cord sera and other biochemical and anthropometric markers, early term delivery in all subjects. RESULTS: Maternal Serum levels of Hsp-70 were significantly higher in patients with GDM than in healthy pregnant women. The umbilical cord levels of Hsp-70 in GDM patients were also increased as compared to healthy pregnant women but missed the commonly acceptable significance level. Cord Hsp-70 levels showed a negatively significant correlation with time of delivery, in women with GDM patients. Cord Hsp-70 levels showed a negatively significant correlation with time of delivery, also in the whole group. CONCLUSIONS: Maternal Hsp-70 was significantly higher in patients with GDM. The obtained results seem to indicate that elevated umbilical cord Hsp-70 values may potentially be used as indicators of risk factor for early term delivery in pregnancies.

 AMAÇ: Bu çalışmanın amacı, hücresel stresin bir belirleyicisi olan Heat shock protein 70 Hsp-70in, gestasyonel diyabet mellitus GDM gebeliklerde maternal serum ve umbilikal kordda yüksek olup olmadığını belirlemek ve farklı serum Hsp-70 konsantrasyonlarının umbilikal kordda, GDMli kadınlarda ve kontrol grubundaki kadınlarda erken doğumun bir göstergesi olarak ilişkilendirilip ilişkilendirilmediğini belirlemektir 37 07-38 67 hafta gebelik. YÖNTEMLER: Çalışma, bu durum kontrol çalışmasında sezaryen doğum olan GDMli 62 hasta GDM grubu ve 22 diyabetik olmayan, sağlıklı kadını içermektedir. Hamileliklerde ve umbilikal kord serumlarında Hsp-70 düzeylerini ve tüm konulardaki erken doğumu içeren diğer biyokimyasal ve antropometrik belirteçleri analiz ettik. BULGULAR: GDMli hastalarda maternal serum Hsp-70 düzeyleri, sağlıklı hamile kadınlardan önemli ölçüde yüksekti. GDM hastalarının umbilikal kord Hsp-70 düzeyleri de sağlıklı hamile kadınlara göre artmıştı ancak genellikle kabul edilebilir düzeyde anlam bulunamadı. Kord Hsp-70 düzeyleri, GDMli kadınlarda doğum zamanı ile negatif anlamlı bir korelasyon gösterdi. Kord Hsp-70 düzeyleri, aynı zamanda tüm grup içinde doğum zamanı ile negatif anlamlı bir korelasyon gösterdi. SONUÇLAR: Maternal Hsp-70, GDMli hastalarda önemli ölçüde yüksekti. Elde edilen sonuçlar, yüksek umbilikal kord Hsp-70 değerlerinin, gebeliklerde erken doğum için bir risk faktörü göstergesi olarak potansiyel olarak kullanılabileceğini göstermektedir.

Article Details

Maternal and Umbilical Cord Heat-Shock Protein 70 Levels in Patients with Gestational Diabetes Mellitus

Authors:

Mete Bertizlioğlu | Setenay Yılmaz | Ayşegül Kebapçılar | Aybike Tazegul | Özlem Seçilmiş | Berat Berrin Gençoğlu Bakbak | Sedat Abuşoğlu | Cetin Celik | Ali Unlu | Nasuh Utku Doğan | Görkem Aktaş

Publisher:

Selcuk University

Main Topics:

Klinik Tıp Bilimleri (Diğer)

Journal:

Genel Tıp Dergisi Vol.34 Issue 2, pp.251-257

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001316109

pISSN:

2602-3741

gestational diabetes mellitus

heat-shock protein 70

Preterm Birthheat-shock protein 70

gestasyonel diyabetes mellitus

erken doğum

Issues

Article Details

Maternal and Umbilical Cord Heat-Shock Protein 70 Levels in Patients with Gestational Diabetes Mellitus

Authors: Mete Bertizlioğlu | Setenay Yılmaz | Ayşegül Kebapçılar | Aybike Tazegul | Özlem Seçilmiş | Berat Berrin Gençoğlu Bakbak | Sedat Abuşoğlu | Cetin Celik | Ali Unlu | Nasuh Utku Doğan | Görkem Aktaş

Publisher: Selcuk University

Main Topics: Klinik Tıp Bilimleri (Diğer)

Journal: Genel Tıp Dergisi Vol.34 Issue 2, pp.251-257

Document Type: Article

Publication Date: 4/2024

Document Language: English

Document ID (Org No.): 2001316109

pISSN: 2602-3741

gestational diabetes mellitus

heat-shock protein 70

Preterm Birthheat-shock protein 70

gestasyonel diyabetes mellitus

erken doğum

Issues

Authors:

Mete Bertizlioğlu | Setenay Yılmaz | Ayşegül Kebapçılar | Aybike Tazegul | Özlem Seçilmiş | Berat Berrin Gençoğlu Bakbak | Sedat Abuşoğlu | Cetin Celik | Ali Unlu | Nasuh Utku Doğan | Görkem Aktaş

Publisher:

Selcuk University

Main Topics:

Klinik Tıp Bilimleri (Diğer)

Journal:

Genel Tıp Dergisi Vol.34 Issue 2, pp.251-257

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001316109

pISSN:

2602-3741