D VİTAMİNİNİN İMMÜN SİSTEM, DERİ VE KANSER İLE İLİŞKİSİ

Mehtap KIDIR

Article Details

D VİTAMİNİNİN İMMÜN SİSTEM, DERİ VE KANSER İLE İLİŞKİSİ

Authors:

Mehtap KIDIR

Publisher:

Süleyman Demirel University

Main Topics:

Surgery & related medical specialties

Journal:

SDU Medical Faculty Journal 2013 Vol.20 Issue 4, pp.158-161

Document Type:

Article

Publication Date:

12/2013

Document Language:

Turkish

Document ID (Org No.):

2000573167

Frequency:

Quarterly

eISSN:

2602-2109

pISSN:

1300-7416

Abstract:

 

The relation of vitamin D with immune system, skin and cancer.In humans, approximately 95% of the total requirement for vitamin D is synthesized in the skin by the effectsof sunlight. The active vitamin D synthesis from 25 (OH) D takes place via the 1-alpha hydroxylase enzymeboth in renal and non-renal tissues. The effect of vitamin D on the receptor level is through active vitaminD. Vitamin D receptors are shown in more than 30 tissues. Non-classical effects of vitamin D are groupedunder three main headings: Regulation of hormone secretion, regulation of immune function, regulation ofcell proliferation and differentiation. The relationship immune system, skin diseases cancer and vitamin Dis the most widely researched topics.

 

İnsanlarda D vitamini ihtiyacının yaklaşık % 95'i güneş ışınlarının etkisiyle deride sentezlenmektedir. Böbrek dışı dokularda da 1-alfa hidroksilaz enzimi aracılığıyla aktif vitamin D sentezi gerçekleşmektedir. D vitamininin reseptör düzeyindeki etkisi aktif vitamin D sayesinde olur. Otuzdan fazla dokuda vitamin D reseptörleri gösterilmiştir. Vitamin D'nin iskelet sistemi dışındaki etkileri 3 ana başlık altında toplanmaktadır: Hormon sekresyonunun regülasyonu, immün fonksiyonların regülasyonu, hücre proliferasyon ve farklılaşmasının düzenlenmesi. İmmun sistem, cilt hastalıkları, kanser vitamin D ile ilişkisi en çok araştırılan konular arasındadır.
Anahtar Kelimeler: D vitamini; kemik dışı etkiler; immün sistem; deri; kanser
SUMMARY
In humans, approximately 95% of the total requirement for vitamin D is synthesized in the skin by the effects of sunlight. The active vitamin D synthesis from 25 (OH) D takes place via the 1-alpha hydroxylase enzyme both in renal and non-renal tissues. The effect of vitamin D on the receptor level is through active vitamin D. Vitamin D receptors are shown in more than 30 tissues. Non-classical effects of vitamin D are grouped under three main headings: Regulation of hormone secretion, regulation of immune function, regulation of cell proliferation and differentiation. The relationship immune system, skin diseases and cancer between vitamin D is the most widely researched topics.
Key words: Vitamin D; nonskeletal effects; immune system; skin; cancer.

Article Details

D VİTAMİNİNİN İMMÜN SİSTEM, DERİ VE KANSER İLE İLİŞKİSİ

Authors: Mehtap KIDIR

Publisher: Süleyman Demirel University

Main Topics: Surgery & related medical specialties

Journal: SDU Medical Faculty Journal 2013 Vol.20 Issue 4, pp.158-161

Document Type: Article

Publication Date: 12/2013

Document Language: Turkish

Document ID (Org No.): 2000573167

Frequency: Quarterly

eISSN: 2602-2109

pISSN: 1300-7416

Issues

Authors:

Mehtap KIDIR

Publisher:

Süleyman Demirel University

Main Topics:

Surgery & related medical specialties

Journal:

SDU Medical Faculty Journal 2013 Vol.20 Issue 4, pp.158-161

Document Type:

Article

Publication Date:

12/2013

Document Language:

Turkish

Document ID (Org No.):

2000573167

Frequency:

Quarterly

eISSN:

2602-2109

pISSN:

1300-7416