Serum vasohibin-1 and suppression of tumorigenicity-2 levels in children with  predialysis chronic kidney disease

Nuran ÇETİN; Nadide Melike SAV

Article Details

Serum vasohibin-1 and suppression of tumorigenicity-2 levels in children with predialysis chronic kidney disease

Authors:

Nuran ÇETİN | Nadide Melike SAV

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 3, pp.576-583

Document Type:

Article

Publication Date:

5/2018

Document Language:

Turkish

Document ID (Org No.):

2000750729

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Abstract:

 

Background/aim: Chronic kidney disease (CKD), which is one of the most important health problems worldwide, could be considered  as an immune inflammatory disease. A prognostic biomarker may be helpful in determining the progression of CKD in children.  We aimed to investigate the serum vasohibin-1 and soluble suppression of tumorigenicity-2 (sST2) levels as potential biomarkers in  children with predialysis CKD.  Materials and methods: Forty-seven children with stage 2-4 CKD and 20 healthy controls were included in this cross-sectional study.  Glomerular filtration rate (GFR) and urinary excretion of protein were measured in 24-h urine samples. Serum vasohibin-1 levels and  sST2 were measured. The results were expressed as pg/mL and ng/mL, respectively.  Results: Serum vasohibin-1 levels were similar between the patients and the control group (P > 0.05), but serum vasohibin-1 levels were  higher in patients with proteinuria than in nonproteinuric patients (2574.5 ± 701.60 vs. 1822.4 ± 300.32 pg/mL, P = 0.001). A positive  correlation was found between serum vasohibin-1 levels and 24-h urine protein values in patients (P = 0.036). Serum sST2 levels were  higher in patients than the control group (P = 0.013). The patients with hypertension had higher sST2 levels than normotensive patients  (P = 0.015). Serum vasohibin-1 and sST2 levels were not correlated with age, GFR, albumin, hemoglobin, or PTH levels.  Conclusion: Serum vasohibin-1 and sST2 levels were not associated with decline in renal function. Elevated serum vasohibin levels may  be a compensatory response to proteinuria in patients with predialysis CKD. The measurement of serum sST2 levels might contribute  to early detection of hypertension in patients.

Article Details

Serum vasohibin-1 and suppression of tumorigenicity-2 levels in children with predialysis chronic kidney disease

Authors: Nuran ÇETİN | Nadide Melike SAV

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 3, pp.576-583

Document Type: Article

Publication Date: 5/2018

Document Language: Turkish

Document ID (Org No.): 2000750729

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Issues

Authors:

Nuran ÇETİN | Nadide Melike SAV

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 3, pp.576-583

Document Type:

Article

Publication Date:

5/2018

Document Language:

Turkish

Document ID (Org No.):

2000750729

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144