Relation between IL-1 β and IL1-ra in Pathogenesis of Febrile Convulsions

Seham Elsaid; Manal Hafez; Eman Saif Eldeen

doi:10.12816/0018773

Article Details

Relation between IL-1 β and IL1-ra in Pathogenesis of Febrile Convulsions

Authors:

Seham Elsaid | Manal Hafez | Eman Saif Eldeen

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2015 Vol.61, pp.745-753

Document Type:

Article

Publication Date:

10/2015

Document Language:

English

Document ID (Org No.):

75241

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

DOI:

10.12816/0018773

Descriptors:

Keywords:

Abstract:

 Background: febrile seizures are the most common form of childhood seizures. Fever is induced by proinflammatory cytokines during infection. The cytokine network may contribute to the generation of febrile seizures in children. Interleukin beta (IL-1 β) and Interleukin receptor antagonist (IL-1ra) have been implicated in the pathogenesis of febrile seizures.Aim of the work: was to estimate the role of IL-1 β and IL-Ra in febrile convulsions and their relation to pathogenesis of febrile convulsions.Methods: serum interleukin I beta (IL-1 β) and interleukin 1 receptor antagonist (IL 1ra) were measured by ELISA technique in twenty five children with febrile seizure and twenty five age matched controls children with febrile illness without convulsion within 24 hours from onset of fever .Results: serum IL-1 β and IL 1ra levels were significantly higher in febrile seizure patients than in fever in controls. Serum IL-1 β and IL 1ra levels were highly significant higher in complex febrile seizures than in simple febrile seizures. Serum levels of IL-1 β and IL 1ra were significantly positive correlated with duration of seizure in patients group.Conclusions: serum levels of IL-1 β and IL 1ra were significantly higher in febrile seizure children. Our study suggest that the inflammatory cytokine may play role in the generation of febrile seizures in children. These information may allow the development of anti- inflammatory therapy targeting these cytokines to prevent febrile seizures or subsequent epileptogenesis

Article Details

Relation between IL-1 β and IL1-ra in Pathogenesis of Febrile Convulsions

Authors:

Seham Elsaid | Manal Hafez | Eman Saif Eldeen

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2015 Vol.61, pp.745-753

Document Type:

Article

Publication Date:

10/2015

Document Language:

English

Document ID (Org No.):

75241

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

DOI:

10.12816/0018773

Descriptors:

CYTOKINESIS

INTERLEUKINS

RECEPTORS

ANTAGONISTS

FEVER

CHILDREN DISEASES

LEBANON

Febrile Seizures

Proinflammatory Cytokines

Interleukin 1-β

Interleukin Receptor 1 Antagonist

Issues

Article Details

Authors: Seham Elsaid | Manal Hafez | Eman Saif Eldeen

Publisher: Pan Arab League of Continuous Medical Education

Main Topics: Medicine

Journal: The Egyptian Journal of Hospital Medicine 2015 Vol.61, pp.745-753

Document Type: Article

Publication Date: 10/2015

Document Language: English

Document ID (Org No.): 75241

Frequency: Quarterly

eISSN: 20907125

pISSN: 16872002

DOI: 10.12816/0018773

Descriptors:

Issues

Authors:

Seham Elsaid | Manal Hafez | Eman Saif Eldeen

Publisher:

Pan Arab League of Continuous Medical Education

Main Topics:

Medicine

Journal:

The Egyptian Journal of Hospital Medicine 2015 Vol.61, pp.745-753

Document Type:

Article

Publication Date:

10/2015

Document Language:

English

Document ID (Org No.):

75241

Frequency:

Quarterly

eISSN:

20907125

pISSN:

16872002

DOI:

10.12816/0018773