Histochemical Mapping of Mast Cells in Oral Dysplasia:  A Window into Carcinogenesis in Rats

Omar Rageh; Sawsan Naguib Abdel Bary; Nermine Raouf Ameen

Article Details

Histochemical Mapping of Mast Cells in Oral Dysplasia: A Window into Carcinogenesis in Rats

Authors:

Omar Rageh | Sawsan Naguib Abdel Bary | Nermine Raouf Ameen

Publisher:

University of Science and Technology, Yemen

Journal:

Yemeni Journal for Medical Sciences Vol.19 Issue 2, pp.0-0

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001538901

pISSN:

2227-961X

Keywords:

Abstract:

 Background: The most common cause of death is cancer. Oral squamous cell carcinoma is the initial phase of more than 95% of oral cavity carcinomas. The earliest histological indication of cancer is dysplasia, which occur before squamous cell carcinoma (SCC) forms.  The risk of transformation to cancer is greater in dysplasia than in normal oral epithelium. Objectives: To demonstrate the correlation between the mast cell count and oral dysplastic lesions severity. Methods and Materials: the study involve 30 rats who randomly allocated into two groups: control and experimental groups. Formaldehyde and 7,12-Dimethylbenz[a]anthracene (DMBA) were applied topically to the rats' buccal mucosa in order to cause carcinogenesis. Mast cell detection using toluidine blue stain. Results: the mast cell count (MCC) was more significant in oral epithelial dysplasia (OED) (high- risk and low- risk dysplasia) than in control and most significantly expressed was in high-risk epithelial dysplasia. Conclusion: As OED severity increased, there was also a significant increase in the number of infiltrating mast cells (MCs). By reducing their tumor-promoting properties, MCs may be a viable target for the treatment of oral premalignant and malignant cancers.

Article Details

Histochemical Mapping of Mast Cells in Oral Dysplasia: A Window into Carcinogenesis in Rats

Authors:

Omar Rageh | Sawsan Naguib Abdel Bary | Nermine Raouf Ameen

Publisher:

University of Science and Technology, Yemen

Journal:

Yemeni Journal for Medical Sciences Vol.19 Issue 2, pp.0-0

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001538901

pISSN:

2227-961X

Mast cells

Oral dysplasia

Carcinogenesis

Histochemical mapping

Buccal mucosa

T.B. staining (Toluidine Blue)

and Oral epithelial dysplasia (OED)

Issues

Article Details

Authors: Omar Rageh | Sawsan Naguib Abdel Bary | Nermine Raouf Ameen

Publisher: University of Science and Technology, Yemen

Journal: Yemeni Journal for Medical Sciences Vol.19 Issue 2, pp.0-0

Document Type: Article

Publication Date: 1/2025

Document Language: English

Document ID (Org No.): 2001538901

pISSN: 2227-961X

Issues

Authors:

Omar Rageh | Sawsan Naguib Abdel Bary | Nermine Raouf Ameen

Publisher:

University of Science and Technology, Yemen

Journal:

Yemeni Journal for Medical Sciences Vol.19 Issue 2, pp.0-0

Document Type:

Article

Publication Date:

1/2025

Document Language:

English

Document ID (Org No.):

2001538901

pISSN:

2227-961X