Evaluation of Antihyperglycemic and Other Complication Effects of Extracts of Thespesia Lampas Dalz and Gibs on Streptozotocin Induced Diabetic Rats

B. Sangameswaran; Baljeet Singh; Gurpreet S. Gill

Article Details

Evaluation of Antihyperglycemic and Other Complication Effects of Extracts of Thespesia Lampas Dalz and Gibs on Streptozotocin Induced Diabetic Rats

Authors:

B. Sangameswaran | Baljeet Singh | Gurpreet S. Gill

Publisher:

The Hashemite University : The Deanship of Scientific Research and Graduate Studies

Main Topics:

Medicine

Journal:

Jordan Journal of Biological Sciences 2012 Vol.5 Issue 3, pp.161-166

Document Type:

Article

Publication Date:

9/2012

Document Language:

English

Document ID (Org No.):

27878

Frequency:

Quarterly

pISSN:

19956673

Descriptors:

Keywords:

Abstract:

 The methanol and aqueous extracts of Thespesia lampas Dalz and Gibs were tested for anti-hyperglycemic, antihyperlipidaemicand spermatogenetic effects of streptozotocin (STZ) induced diabetic rats. Diabetes was induced in adultmale albino Wister rats by intra peritoneal (i.p) injection of streptozotocin at a dose of 150 mg/kg. Methanol and aqueousextracts of T. lampas (METL and AETL) at doses of 300 and 600 mg/kg b. wt were administered as a single dose per day todiabetes rats for the period of 15 days, respectively. The blood glucose levels and serum lipid profiles like total cholesterol,triglycerides, phospholipids, low density, very low density and high density lipoprotein and serum enzymes like ALT, ASP,ALP were measured in the diabetic and non diabetic rats. An oral glucose tolerance test (OGTT) was also performed, inwhich there was a significant improvement in glucose tolerance in rats treated with extracts. A comparison was madebetween the extracts and standard anti-diabetic drug glibenclamide. The extracts exhibited significant anti-hyperglycemic andanti-hyperlipidaemic effects on STZ induced diabetic rats when compared to that of standard drug (Glibenclamide 500μg/kg).The present investigation of this plant established pharmacological evidence to support the folklore claim that it is an antidiabeticagent.

Article Details

Evaluation of Antihyperglycemic and Other Complication Effects of Extracts of Thespesia Lampas Dalz and Gibs on Streptozotocin Induced Diabetic Rats

Authors:

B. Sangameswaran | Baljeet Singh | Gurpreet S. Gill

Publisher:

The Hashemite University : The Deanship of Scientific Research and Graduate Studies

Main Topics:

Medicine

Journal:

Jordan Journal of Biological Sciences 2012 Vol.5 Issue 3, pp.161-166

Document Type:

Article

Publication Date:

9/2012

Document Language:

English

Document ID (Org No.):

27878

Frequency:

Quarterly

pISSN:

19956673

Descriptors:

HYPERGLYCOSEMIA

DIABETES

METHANOL

MICE

LABORATORY ANIMALS

TRIGLYCERIDES

SPERMATOGENESIS

Anti-Hyperglycemic

Anti-Hyperlipidaemic

Streptozotocin

Spermatogenesis

Thespesia lampas

Issues

Article Details

Authors: B. Sangameswaran | Baljeet Singh | Gurpreet S. Gill

Publisher: The Hashemite University : The Deanship of Scientific Research and Graduate Studies

Main Topics: Medicine

Journal: Jordan Journal of Biological Sciences 2012 Vol.5 Issue 3, pp.161-166

Document Type: Article

Publication Date: 9/2012

Document Language: English

Document ID (Org No.): 27878

Frequency: Quarterly

pISSN: 19956673

Descriptors:

Issues

Authors:

B. Sangameswaran | Baljeet Singh | Gurpreet S. Gill

Publisher:

The Hashemite University : The Deanship of Scientific Research and Graduate Studies

Main Topics:

Medicine

Journal:

Jordan Journal of Biological Sciences 2012 Vol.5 Issue 3, pp.161-166

Document Type:

Article

Publication Date:

9/2012

Document Language:

English

Document ID (Org No.):

27878

Frequency:

Quarterly

pISSN:

19956673