Plasma Free Amino Acid and Carnitine Levels in Pregnant Women with Hydatidiform Mole: A Case-Controlled Study

Hacer Uyanikoglu; İsmail Koyuncu; Sibel Sak; Mehmet Emin Tasduzen; Ataman Gönel; Muhammet Erdal Sak; Mert Ulaş Barut

Article Details

Plasma Free Amino Acid and Carnitine Levels in Pregnant Women with Hydatidiform Mole: A Case-Controlled Study

Authors:

Hacer Uyanikoglu | İsmail Koyuncu | Sibel Sak | Mehmet Emin Tasduzen | Ataman Gönel | Muhammet Erdal Sak | Mert Ulaş Barut

Publisher:

Harran University

Main Topics:

Kadın Hastalıkları ve Doğum

Journal:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.21 Issue 1, pp.131-137

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001313097

pISSN:

1304-9623

Keywords:

Abstract:

 Background: To determine plasma free amino acid FAA and carnitine levels in pregnant women with hydatidiform mole HM. Materials and Methods: Twenty-three pregnant women with HM, and 24 healthy pregnant wo-men as controls were enrolled in the study. FAA and carnitine concentrations were measured in plasma using liquid chromatographytandem mass spectrometry LC-MS. Results: The levels of alanine, arginine, and valine from the 14 amino acids examined were signif-icantly lower in the HM group than in the healthy group p  0.019, p  0.009, and p  0.03, respec-tively. In addition, several carnitines, C8DC, C16:1, and C18, of the 27 carnitines examined were significantly higher in the HM group than in the control group p  0.021, p  0.03, and p  0.021, respectively. Conclusions: This study demonstrated that a decrease in some plasma FAAs and an increase in some plasma carnitine levels might be effective in the pathogenesis of HM.

 Background: To determine plasma free amino acid FAA and carnitine levels in pregnant women with hydatidiform mole HM. Materials and Methods: Twenty-three pregnant women with HM, and 24 healthy pregnant wo-men as controls were enrolled in the study. FAA and carnitine concentrations were measured in plasma using liquid chromatographytandem mass spectrometry LC-MS. Results: The levels of alanine, arginine, and valine from the 14 amino acids examined were signif-icantly lower in the HM group than in the healthy group p  0.019, p  0.009, and p  0.03, respec-tively. In addition, several carnitines, C8DC, C16:1, and C18, of the 27 carnitines examined were significantly higher in the HM group than in the control group p  0.021, p  0.03, and p  0.021, respectively. Conclusions: This study demonstrated that a decrease in some plasma FAAs and an increase in some plasma carnitine levels might be effective in the pathogenesis of HM.

 Background: To determine plasma free amino acid FAA and carnitine levels in pregnant women with hydatidiform mole HM. Materials and Methods: Twenty-three pregnant women with HM, and 24 healthy pregnant wo-men as controls were enrolled in the study. FAA and carnitine concentrations were measured in plasma using liquid chromatographytandem mass spectrometry LC-MS. Results: The levels of alanine, arginine, and valine from the 14 amino acids examined were signif-icantly lower in the HM group than in the healthy group p  0.019, p  0.009, and p  0.03, respec-tively. In addition, several carnitines, C8DC, C16:1, and C18, of the 27 carnitines examined were significantly higher in the HM group than in the control group p  0.021, p  0.03, and p  0.021, respectively. Conclusions: This study demonstrated that a decrease in some plasma FAAs and an increase in some plasma carnitine levels might be effective in the pathogenesis of HM.

 Amaç: Hidatidiform mol HMli gebe kadınlarda plazma serbest amino asit FAA ve karnitin düzeylerini belirlemek. Materyal ve metod: Çalışmaya 23 HMli gebe ve kontrol grubu olarak 24 sağlıklı gebe dahil edildi. FAA ve karnitin konsantrasyonları, sıvı kromatografisitandem kütle spektrometrisi LC-MS kullanılarak plazmada ölçüldü. Bulgular: İncelenen 14 amino asitten alanin, arginin ve valin düzeyleri HM grubunda sağlıklı gruba göre anlamlı derecede düşüktü sırasıyla p  0,019, p  0,009 ve p  0,03. Ek olarak, incelenen 27 karnitinden birkaç karnitin, C8DC, C16:1 ve C18, HM grubunda kontrol grubuna göre önemli ölçüde daha yüksekti sırasıyla p  0,021, p  0,03 ve p  0,021. Sonuç: Bu çalışma, bazı FAAlerin plazma seviyesindeki azalmanın ve bazı karnitinlerin de plazma düzeylerindeki artışın HM patogenezinde etkili olabileceğini ortaya koydu.

Article Details

Plasma Free Amino Acid and Carnitine Levels in Pregnant Women with Hydatidiform Mole: A Case-Controlled Study

Authors:

Hacer Uyanikoglu | İsmail Koyuncu | Sibel Sak | Mehmet Emin Tasduzen | Ataman Gönel | Muhammet Erdal Sak | Mert Ulaş Barut

Publisher:

Harran University

Main Topics:

Kadın Hastalıkları ve Doğum

Journal:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.21 Issue 1, pp.131-137

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001313097

pISSN:

1304-9623

carnitine

free amino acid

hydatidiform mole

pregnancykarnitin

serbest amino asit

gebelik

hidatidiform mol

Issues

Article Details

Authors: Hacer Uyanikoglu | İsmail Koyuncu | Sibel Sak | Mehmet Emin Tasduzen | Ataman Gönel | Muhammet Erdal Sak | Mert Ulaş Barut

Publisher: Harran University

Main Topics: Kadın Hastalıkları ve Doğum

Journal: Harran Üniversitesi Tıp Fakültesi Dergisi Vol.21 Issue 1, pp.131-137

Document Type: Article

Publication Date: 4/2024

Document Language: English

Document ID (Org No.): 2001313097

pISSN: 1304-9623

Issues

Authors:

Hacer Uyanikoglu | İsmail Koyuncu | Sibel Sak | Mehmet Emin Tasduzen | Ataman Gönel | Muhammet Erdal Sak | Mert Ulaş Barut

Publisher:

Harran University

Main Topics:

Kadın Hastalıkları ve Doğum

Journal:

Harran Üniversitesi Tıp Fakültesi Dergisi Vol.21 Issue 1, pp.131-137

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001313097

pISSN:

1304-9623