Spectrophotometric determination of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors in pharmaceutical preparations

Gamze ERGİN; Sena ÇAĞLAR; Armağan ÖNAL; Sıdıka Ertürk TOKER

Article Details

Spectrophotometric determination of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors in pharmaceutical preparations

Authors:

Gamze ERGİN | Sena ÇAĞLAR | Armağan ÖNAL | Sıdıka Ertürk TOKER

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2013 Vol.37 Issue 2, pp.171-181

Document Type:

Article

Publication Date:

1/2013

Document Language:

Turkish

Document ID (Org No.):

2000727438

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

Abstract:

 

Simple and accurate spectrophotometric methods are presented  for the determination of five 3-hydroxy-3-methylglutaryl coenzyme-A  (HMG-CoA) reductase inhibitors (statins), namely atorvastatin,  fluvastatin, pitavastatin, rosuvastatin, and simvastatin, in  pharmaceutical preparations.  The methods are based on the reaction of  drugs as n-electron donor with 7,7,8,8-tetracyanoquinodimethane as  p-acceptors to give highly colored complex species.  All variables  were studied in order to optimize the reaction conditions.  Beer's law  was obeyed in the concentration ranges 4--20 m g mL-1, 4--12 m  g mL-1, 0.8--2.4 m g mL-1, 4--14 m g mL-1, and 2.5--20  m g mL-1 for atorvastatin, fluvastatin, pitavastatin,  rosuvastatin, and simvastatin, respectively.  The proposed methods  were successfully applied to the pharmaceutical preparations without  any interference from excipients.

 

Simple and accurate spectrophotometric methods are presented  for the determination of five 3-hydroxy-3-methylglutaryl coenzyme-A  (HMG-CoA) reductase inhibitors (statins), namely atorvastatin,  fluvastatin, pitavastatin, rosuvastatin, and simvastatin, in  pharmaceutical preparations.  The methods are based on the reaction of  drugs as n-electron donor with 7,7,8,8-tetracyanoquinodimethane as  p-acceptors to give highly colored complex species.  All variables  were studied in order to optimize the reaction conditions.  Beer's law  was obeyed in the concentration ranges 4--20 m g mL-1, 4--12 m  g mL-1, 0.8--2.4 m g mL-1, 4--14 m g mL-1, and 2.5--20  m g mL-1 for atorvastatin, fluvastatin, pitavastatin,  rosuvastatin, and simvastatin, respectively.  The proposed methods  were successfully applied to the pharmaceutical preparations without  any interference from excipients.

Article Details

Spectrophotometric determination of 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitors in pharmaceutical preparations

Authors: Gamze ERGİN | Sena ÇAĞLAR | Armağan ÖNAL | Sıdıka Ertürk TOKER

Publisher: TUBITAK

Journal: Turkish Journal of Chemistry 2013 Vol.37 Issue 2, pp.171-181

Document Type: Article

Publication Date: 1/2013

Document Language: Turkish

Document ID (Org No.): 2000727438

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

Issues

Authors:

Gamze ERGİN | Sena ÇAĞLAR | Armağan ÖNAL | Sıdıka Ertürk TOKER

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2013 Vol.37 Issue 2, pp.171-181

Document Type:

Article

Publication Date:

1/2013

Document Language:

Turkish

Document ID (Org No.):

2000727438

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527