Effect of Paternal Age on Miscarriage Rates in Couples Undergoing In Vitro Fertilization/Intracytoplasmic Sperm Injection

Kadriye Erdoğan; Nazlı Tunca Şanlıer; Huri Güvey; Serdar Dilbaz; İnci Kahyaoğlu; Yaprak Ustun

Article Details

Effect of Paternal Age on Miscarriage Rates in Couples Undergoing In Vitro Fertilization/Intracytoplasmic Sperm Injection

Authors:

Kadriye Erdoğan | Nazlı Tunca Şanlıer | Huri Güvey | Serdar Dilbaz | İnci Kahyaoğlu | Yaprak Ustun

Publisher:

Duzce University

Main Topics:

Clinical Sciences

Journal:

Duzce Medical Journal Vol.25 Issue 1, pp.45-49

Document Type:

Article

Publication Date:

4/2023

Document Language:

English

Document ID (Org No.):

2001284108

pISSN:

1307-671X

Keywords:

Abstract:

 Aim: The aim of this study was to determine the effect of paternal age on miscarriage rates in couples undergoing in vitro fertilizationintracytoplasmic sperm injection treatment cycles. Material and Methods: Patients were classified into two groups. The study group consisted of the patients whose pregnancy resulted in a miscarriage n73 and a control group in which the patients had a live singleton birth n256. Demographic characteristics, treatment indications, duration of infertility, menstruation day 3 follicle stimulating hormone, estradiol, luteinizing hormone, total antral follicle count, anti-Mullerian hormone levels and controlled ovarian stimulation parameters, day of trigger, estradiol and progesterone levels on the day of trigger, the total number of oocytes retrieved, the number of mature oocytes, the number and quality of the embryo, endometrial thickness on the day of trigger, oocyte pick up and embryo transfer, the distance of embryo-fundus and the day of embryo transfer were recorded. Results: Totally 329 women were included in the present study. The number of patients with the diagnosis of unexplained infertility was statistically significantly higher in the study group than in the control group p0.020. Maternal age was found statistically significantly higher in the study group than in the control group p0.025. When maternal age increased by 1 unit, the risk of miscarriage increased by 8.7 and those with unexplained infertility had a 75.6 higher risk of miscarriage than those without unexplained infertility. Conclusion: Paternal age was not associated with miscarriage whereas maternal age and unexplained infertility had a positive correlation with miscarriage rate.

 Aim: The aim of this study was to determine the effect of paternal age on miscarriage rates in couples undergoing in vitro fertilizationintracytoplasmic sperm injection treatment cycles. Material and Methods: Patients were classified into two groups. The study group consisted of the patients whose pregnancy resulted in a miscarriage n73 and a control group in which the patients had a live singleton birth n256. Demographic characteristics, treatment indications, duration of infertility, menstruation day 3 follicle stimulating hormone, estradiol, luteinizing hormone, total antral follicle count, anti-Mullerian hormone levels and controlled ovarian stimulation parameters, day of trigger, estradiol and progesterone levels on the day of trigger, the total number of oocytes retrieved, the number of mature oocytes, the number and quality of the embryo, endometrial thickness on the day of trigger, oocyte pick up and embryo transfer, the distance of embryo-fundus and the day of embryo transfer were recorded. Results: Totally 329 women were included in the present study. The number of patients with the diagnosis of unexplained infertility was statistically significantly higher in the study group than in the control group p0.020. Maternal age was found statistically significantly higher in the study group than in the control group p0.025. When maternal age increased by 1 unit, the risk of miscarriage increased by 8.7 and those with unexplained infertility had a 75.6 higher risk of miscarriage than those without unexplained infertility. Conclusion: Paternal age was not associated with miscarriage whereas maternal age and unexplained infertility had a positive correlation with miscarriage rate.

 Aim: The aim of this study was to determine the effect of paternal age on miscarriage rates in couples undergoing in vitro fertilizationintracytoplasmic sperm injection treatment cycles. Material and Methods: Patients were classified into two groups. The study group consisted of the patients whose pregnancy resulted in a miscarriage n73 and a control group in which the patients had a live singleton birth n256. Demographic characteristics, treatment indications, duration of infertility, menstruation day 3 follicle stimulating hormone, estradiol, luteinizing hormone, total antral follicle count, anti-Mullerian hormone levels and controlled ovarian stimulation parameters, day of trigger, estradiol and progesterone levels on the day of trigger, the total number of oocytes retrieved, the number of mature oocytes, the number and quality of the embryo, endometrial thickness on the day of trigger, oocyte pick up and embryo transfer, the distance of embryo-fundus and the day of embryo transfer were recorded. Results: Totally 329 women were included in the present study. The number of patients with the diagnosis of unexplained infertility was statistically significantly higher in the study group than in the control group p0.020. Maternal age was found statistically significantly higher in the study group than in the control group p0.025. When maternal age increased by 1 unit, the risk of miscarriage increased by 8.7 and those with unexplained infertility had a 75.6 higher risk of miscarriage than those without unexplained infertility. Conclusion: Paternal age was not associated with miscarriage whereas maternal age and unexplained infertility had a positive correlation with miscarriage rate.

 Amaç: Bu çalışmanın amacı in vitro fertilizasyonintrasitoplazmik sperm enjeksiyonu tedavi siklusları uygulanan çiftlerde paternal yaşın düşük oranları üzerindeki etkisini belirlemektir. Gereç ve Yöntemler: Hastalar iki gruba ayrıldı. Gebeliği düşükle sonuçlanan hastalar n73 çalışma grubunu ve canlı tekil doğum yapan hastalar n256 ise kontrol grubunu oluşturdu. Demografik özellikler, tedavi endikasyonları, infertilite süresi, adetin 3. günü folikül uyarıcı hormon, östradiol, lüteinize edici hormon, toplam antral folikül sayısı, anti-Müllerian hormon seviyeleri ve kontrollü ovaryan stimülasyon parametreleri, tetikleme günü, tetikleme gününde östradiol ve progesteron seviyeleri, toplanan toplam oosit sayısı, matur oosit sayısı, embriyo sayısı ve kalitesi, tetikleme, oosit pick-up ve embriyo transfer gününde endometrial kalınlık, embriyo-fundus mesafesi ve embriyo transfer günü kaydedildi. Bulgular: Bu çalışmaya toplam 329 kadın dahil edildi. Açıklanamayan infertilite tanısı alan hasta sayısı çalışma grubunda kontrol grubuna göre istatistiksel olarak anlamlı derecede daha yüksek idi p0,020. Anne yaşının, çalışma grubunda kontrol grubuna göre istatistiksel olarak anlamlı derecede daha yüksek olduğu bulundu p0,025. Anne yaşı 1 birim arttığında, düşük yapma riskinin de 8,7 oranında arttığı ve açıklanamayan infertilitesi olanların açıklanamayan infertilitesi olmayanlara göre ise 75,6 oranında daha yüksek oranda düşük yapma riskine sahip olduğu görüldü. Sonuç: Paternal yaş düşük yapma ile ilişkili olarak bulunmazken, anne yaşı ve açıklanamayan infertilite ile düşük oranı arasında pozitif bir korelasyon olduğu görüldü.

Article Details

Effect of Paternal Age on Miscarriage Rates in Couples Undergoing In Vitro Fertilization/Intracytoplasmic Sperm Injection

Authors:

Kadriye Erdoğan | Nazlı Tunca Şanlıer | Huri Güvey | Serdar Dilbaz | İnci Kahyaoğlu | Yaprak Ustun

Publisher:

Duzce University

Main Topics:

Clinical Sciences

Journal:

Duzce Medical Journal Vol.25 Issue 1, pp.45-49

Document Type:

Article

Publication Date:

4/2023

Document Language:

English

Document ID (Org No.):

2001284108

pISSN:

1307-671X

Paternal age

miscarriage rate

unexplained infertility

maternal age

IVF/ICSI

Paternal yaş

düşük oranı

açıklanamayan infertilite

anne yaşı

IVF/ICSI

Issues

Article Details

Authors: Kadriye Erdoğan | Nazlı Tunca Şanlıer | Huri Güvey | Serdar Dilbaz | İnci Kahyaoğlu | Yaprak Ustun

Publisher: Duzce University

Main Topics: Clinical Sciences

Journal: Duzce Medical Journal Vol.25 Issue 1, pp.45-49

Document Type: Article

Publication Date: 4/2023

Document Language: English

Document ID (Org No.): 2001284108

pISSN: 1307-671X

Issues

Authors:

Kadriye Erdoğan | Nazlı Tunca Şanlıer | Huri Güvey | Serdar Dilbaz | İnci Kahyaoğlu | Yaprak Ustun

Publisher:

Duzce University

Main Topics:

Clinical Sciences

Journal:

Duzce Medical Journal Vol.25 Issue 1, pp.45-49

Document Type:

Article

Publication Date:

4/2023

Document Language:

English

Document ID (Org No.):

2001284108

pISSN:

1307-671X