S. cerevisiae ββ\beta-glucan reduced viability of mouse hepatoma cells in vitro

ARTUR JAVMEN; AUSRA NEMEIKAITE-CENIENE; SAULIUS GRIGISKIS; IRENA JONAUSKIENE; MARK RUDENKOV; DARIUS KACIANAUSKAS; MYKOLAS MAURICAS

Article Details

S. cerevisiae ββ\beta-glucan reduced viability of mouse hepatoma cells in vitro

Authors:

ARTUR JAVMEN | AUSRA NEMEIKAITE-CENIENE | SAULIUS GRIGISKIS | IRENA JONAUSKIENE | MARK RUDENKOV | DARIUS KACIANAUSKAS | MYKOLAS MAURICAS

Publisher:

TUBITAK

Journal:

Turkish Journal of Biology 2015 Vol.39 Issue 4

Document Type:

Article

Publication Date:

8/2015

Document Language:

Turkish

Document ID (Org No.):

2000811877

Frequency:

Bimonthly

eISSN:

1303-6092

pISSN:

1300-0152

Keywords:

Abstract:

 

ββ\beta-Glucan is a natural polymer, which is widely studied due to its multiple immunomodulatory properties. In addition, recent findings indicate potent antitumor properties of ββ\beta-glucan. Saccharomyces cerevisiae, baker's yeast, is one of the commonly used sources of ββ\beta-1,3-glucan. The aim of this work was to investigate S. cerevisiae ββ\beta-glucan immunomodulatory activity against cancer cells.In our experiments, BALB/c mice were fed with insoluble whole ββ\beta-glucan particles, and then their blood was collected for experiments. MH-22a hepatoma cells were treated with the blood of mice fed with ββ\beta-glucan, and tumor cell viability was investigated after the treatment.The obtained results demonstrated that leukocytes in vivoprimed with whole glucan particles, in combination with soluble ββ\beta-glucan, decreased MH-22a hepatoma cell viabilityin vitro.Our study has indicated that ββ\beta-glucan obtained from S. cerevisiae potentially primes mouse whole blood leukocytes to induce cell death of mouse hepatoma cells.

 

ββ\beta-Glucan is a natural polymer, which is widely studied due to its multiple immunomodulatory properties. In addition, recent findings indicate potent antitumor properties of ββ\beta-glucan. Saccharomyces cerevisiae, baker's yeast, is one of the commonly used sources of ββ\beta-1,3-glucan. The aim of this work was to investigate S. cerevisiae ββ\beta-glucan immunomodulatory activity against cancer cells.In our experiments, BALB/c mice were fed with insoluble whole ββ\beta-glucan particles, and then their blood was collected for experiments. MH-22a hepatoma cells were treated with the blood of mice fed with ββ\beta-glucan, and tumor cell viability was investigated after the treatment.The obtained results demonstrated that leukocytes in vivoprimed with whole glucan particles, in combination with soluble ββ\beta-glucan, decreased MH-22a hepatoma cell viabilityin vitro.Our study has indicated that ββ\beta-glucan obtained from S. cerevisiae potentially primes mouse whole blood leukocytes to induce cell death of mouse hepatoma cells.

Article Details

S. cerevisiae ββ\beta-glucan reduced viability of mouse hepatoma cells in vitro

Authors: ARTUR JAVMEN | AUSRA NEMEIKAITE-CENIENE | SAULIUS GRIGISKIS | IRENA JONAUSKIENE | MARK RUDENKOV | DARIUS KACIANAUSKAS | MYKOLAS MAURICAS

Publisher: TUBITAK

Journal: Turkish Journal of Biology 2015 Vol.39 Issue 4

Document Type: Article

Publication Date: 8/2015

Document Language: Turkish

Document ID (Org No.): 2000811877

Frequency: Bimonthly

eISSN: 1303-6092

pISSN: 1300-0152

ββ\beta-Glucan

yeast

cancer

mice

Issues

Authors:

ARTUR JAVMEN | AUSRA NEMEIKAITE-CENIENE | SAULIUS GRIGISKIS | IRENA JONAUSKIENE | MARK RUDENKOV | DARIUS KACIANAUSKAS | MYKOLAS MAURICAS

Publisher:

TUBITAK

Journal:

Turkish Journal of Biology 2015 Vol.39 Issue 4

Document Type:

Article

Publication Date:

8/2015

Document Language:

Turkish

Document ID (Org No.):

2000811877

Frequency:

Bimonthly

eISSN:

1303-6092

pISSN:

1300-0152