Synthesis and Biological Evaluation of 3-Alkyl(Aryl)-4-(4-methylthio-benzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-one Derivatives

Özlem Gürsoy Kol; Fevzi Aytemiz; Sevda Manap; Haydar Yüksek

Article Details

Synthesis and Biological Evaluation of 3-Alkyl(Aryl)-4-(4-methylthio-benzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-one Derivatives

Authors:

Özlem Gürsoy Kol | Fevzi Aytemiz | Sevda Manap | Haydar Yüksek

Publisher:

Kafkas University

Main Topics:

Organik Kimyasal Sentez

Journal:

Caucasian Journal of Science Vol.11 Issue 1, pp.50-57

Document Type:

Article

Publication Date:

2/2024

Document Language:

English

Document ID (Org No.):

2001324548

pISSN:

2148-6840

Keywords:

Abstract:

 In the present study, 3-alkylaryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 3c, f, e reacted with 4-methylthiobenzaldehyde to afford 3-alkylaryl-4-4-methylthio-benzylideneamino-4,5-dihidro-1H-1,2,4-triazol-5-ones 4c, f, e. The structures of three new compounds were established from the elemental analysis, IR, 1H NMR, and 13C NMR spectral data. The newly synthesized and recently synthesized 3-alkylaryl-4-4-methylthiobenzylideneamino-4,5-dihidro-1H-1,2,4-triazol-5-one derivatives were analyzed using three methods for antioxidant activities. Compound 4a showed the best activity for the metal chelating effect. Furthermore, the compounds antimicrobial activity was screened.

 In the present study, 3-alkylaryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 3c, f, e reacted with 4-methylthiobenzaldehyde to afford 3-alkylaryl-4-4-methylthio-benzylideneamino-4,5-dihidro-1H-1,2,4-triazol-5-ones 4c, f, e. The structures of three new compounds were established from the elemental analysis, IR, 1H NMR, and 13C NMR spectral data. The newly synthesized and recently synthesized 3-alkylaryl-4-4-methylthiobenzylideneamino-4,5-dihidro-1H-1,2,4-triazol-5-one derivatives were analyzed using three methods for antioxidant activities. Compound 4a showed the best activity for the metal chelating effect. Furthermore, the compounds antimicrobial activity was screened.

 In the present study, 3-alkylaryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 3c, f, e reacted with 4-methylthiobenzaldehyde to afford 3-alkylaryl-4-4-methylthio-benzylideneamino-4,5-dihidro-1H-1,2,4-triazol-5-ones 4c, f, e. The structures of three new compounds were established from the elemental analysis, IR, 1H NMR, and 13C NMR spectral data. The newly synthesized and recently synthesized 3-alkylaryl-4-4-methylthiobenzylideneamino-4,5-dihidro-1H-1,2,4-triazol-5-one derivatives were analyzed using three methods for antioxidant activities. Compound 4a showed the best activity for the metal chelating effect. Furthermore, the compounds antimicrobial activity was screened.

 In the present study, 3-alkylaryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 3c, f, e reacted with 4-methylthiobenzaldehyde to afford 3-alkylaryl-4-4-methylthio-benzylideneamino-4,5-dihidro-1H-1,2,4-triazol-5-ones 4c, f, e. The structures of three new compounds were established from the elemental analysis, IR, 1H NMR, and 13C NMR spectral data. The newly synthesized and recently synthesized 3-alkylaryl-4-4-methylthiobenzylideneamino-4,5-dihidro-1H-1,2,4-triazol-5-one derivatives were analyzed using three methods for antioxidant activities. Compound 4a showed the best activity for the metal chelating effect. Furthermore, the compounds antimicrobial activity was screened.

Article Details

Synthesis and Biological Evaluation of 3-Alkyl(Aryl)-4-(4-methylthio-benzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-one Derivatives

Authors:

Özlem Gürsoy Kol | Fevzi Aytemiz | Sevda Manap | Haydar Yüksek

Publisher:

Kafkas University

Main Topics:

Organik Kimyasal Sentez

Journal:

Caucasian Journal of Science Vol.11 Issue 1, pp.50-57

Document Type:

Article

Publication Date:

2/2024

Document Language:

English

Document ID (Org No.):

2001324548

pISSN:

2148-6840

1,2,4-triazole

Synthesis

Antioxidant activity

Antimicrobial activity

Issues

Article Details

Synthesis and Biological Evaluation of 3-Alkyl(Aryl)-4-(4-methylthio-benzylideneamino)-4,5-dihidro-1H-1,2,4-triazol-5-one Derivatives

Authors: Özlem Gürsoy Kol | Fevzi Aytemiz | Sevda Manap | Haydar Yüksek

Publisher: Kafkas University

Main Topics: Organik Kimyasal Sentez

Journal: Caucasian Journal of Science Vol.11 Issue 1, pp.50-57

Document Type: Article

Publication Date: 2/2024

Document Language: English

Document ID (Org No.): 2001324548

pISSN: 2148-6840

1,2,4-triazole

Synthesis

Antioxidant activity

Antimicrobial activity

Issues

Authors:

Özlem Gürsoy Kol | Fevzi Aytemiz | Sevda Manap | Haydar Yüksek

Publisher:

Kafkas University

Main Topics:

Organik Kimyasal Sentez

Journal:

Caucasian Journal of Science Vol.11 Issue 1, pp.50-57

Document Type:

Article

Publication Date:

2/2024

Document Language:

English

Document ID (Org No.):

2001324548

pISSN:

2148-6840