Treatment of severe aplastic anemia with cyclosporin-a and high-dose methylprednisolone

N. Üskent; M. Danacı; M. Özel; M. Yaylacı; H. Tor

Article Details

Treatment of severe aplastic anemia with cyclosporin-a and high-dose methylprednisolone

Authors:

N. Üskent | M. Danacı | M. Özel | M. Yaylacı | H. Tor

Publisher:

Marmara University

Main Topics:

Diseases

Journal:

Marmara Medical Journal 1992 Vol.5 Issue 1, pp.27-30

Document Type:

Article

Publication Date:

12/1991

Document Language:

Turkish

Document ID (Org No.):

2000528003

Frequency:

Monthly

eISSN:

1309-9469

pISSN:

1019-1941

Abstract:

 


15 patients with severe aplastic anemia were treated with an immunosuppresive regimen consisting of Cyclosporin-A(CsA) and highdose méthylprednisolone (HMP). Initially CsA was given orally at a dosage of 10 mg/kg/day and monitoring the serum level of the drug, blood levels of 200-500 ng/ml were maintained thereafter. CsA treatment was continued at least 3 months at which time the treatment was terminated in unresponsive patients depending on the peripheral cell counts. HMP was administered simultaneously with CsA at 30 mg/kg/day IV for 3 days, 20 mg/kg/day IV for 3 days and 10 mg/kg/day IV for 4 days. Within 3 months improvement of hematopoiesis was seen in 6 patients (40 %). First signs of response were seen in 21-69 (34) days. This was followed by complete remission in 3 patients, partial remission in 2 patients and minimal improvement in 1 patient. Remissions were proved to be dependent on the continued administration of CsA. Sequential changes of T-cell subsets using APAAP method revealed an increasing ratio of T-helper cells to T-suppressor cells. This Observation strongly suggests the role of T-cells in the pathogenesis of some cases of aplastic anemia.

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Article Details

Treatment of severe aplastic anemia with cyclosporin-a and high-dose methylprednisolone

Authors: N. Üskent | M. Danacı | M. Özel | M. Yaylacı | H. Tor

Publisher: Marmara University

Main Topics: Diseases

Journal: Marmara Medical Journal 1992 Vol.5 Issue 1, pp.27-30

Document Type: Article

Publication Date: 12/1991

Document Language: Turkish

Document ID (Org No.): 2000528003

Frequency: Monthly

eISSN: 1309-9469

pISSN: 1019-1941

Issues

Authors:

N. Üskent | M. Danacı | M. Özel | M. Yaylacı | H. Tor

Publisher:

Marmara University

Main Topics:

Diseases

Journal:

Marmara Medical Journal 1992 Vol.5 Issue 1, pp.27-30

Document Type:

Article

Publication Date:

12/1991

Document Language:

Turkish

Document ID (Org No.):

2000528003

Frequency:

Monthly

eISSN:

1309-9469

pISSN:

1019-1941