The relationship between neutrophil percentage-to-albumin ratio and infarct related artery patency in patients with acute coronary syndrome

Alkame Akgümüş; Ali Duygu; Ahmet Balun

Article Details

The relationship between neutrophil percentage-to-albumin ratio and infarct related artery patency in patients with acute coronary syndrome

Authors:

Alkame Akgümüş | Ali Duygu | Ahmet Balun

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Kardiyoloji

Journal:

Journal of Health Sciences and Medicine Vol.8 Issue 2, pp.333-337

Document Type:

Article

Publication Date:

3/2025

Document Language:

English

Document ID (Org No.):

2001343101

pISSN:

2636-8579

Keywords:

Abstract:

 Aims: One of the leading causes of death and disease burden globally is coronary heart disease CHD. The primary cause of acute coronary syndrome ACS is atherosclerotic plaque rupture and thrombus development. The prognosis of ACS patients is also linked to atherosclerotic plaques, inflammatory cell infiltration lymphocytes, monocytes, and neutrophils, and inflammation indicators. Low serum albumin SA levels have been linked to death in ACS patients in earlier research. In our study, we aimed to investigate the association of neutrophil percentage-to-albumin ratio NPAR with infarct-related adverse cardiac events MACE and infarct-related coronary artery patency IRA. Methods: The NPAR ratio was calculated based on the past laboratory findings of patients admitted with ACS who underwent coronary angiography CAG, which were registered in the data system at the time of admission. A total of 87 patients were included in the study. Of these patients, 62 71 were non-patent and 25 29 were patent IRA patients. Results: NPAR was significantly higher in the non-patent group 19.223.14 and 17.142.78 p0.004. In multivariable logistic regression analysis, NPAR p0.027, odds ratio OR: 0.787, 95 confidence intervals CIs: 0.637-0.974 levels were found to be independent predictors of patent IRA. As revealed by the ROC curve analysis, the cut-off value of 17.88 for NPAR predicted the non-patent IRA with a sensitivity of 64 and specificity of 64 AUC: 0.681; CIs: 0.588-0.809; p0.008 NPAR was significantly higher in the MACE group 22.833.85 and 17.952.49 p0.001. Conclusion: In conclusion, inflammatory markers have been and are being used as predictive parameters for cardiovascular diseases in many studies. In our study, we focused on neutrophils and albumin. These findings revealed that NPAR is a independent predictor of IRA patency and long term mortality. We also indicated that NPAR may have a predictive role for mortality in the long-term follow-up of ACS patients.

 Aims: One of the leading causes of death and disease burden globally is coronary heart disease CHD. The primary cause of acute coronary syndrome ACS is atherosclerotic plaque rupture and thrombus development. The prognosis of ACS patients is also linked to atherosclerotic plaques, inflammatory cell infiltration lymphocytes, monocytes, and neutrophils, and inflammation indicators. Low serum albumin SA levels have been linked to death in ACS patients in earlier research. In our study, we aimed to investigate the association of neutrophil percentage-to-albumin ratio NPAR with infarct-related adverse cardiac events MACE and infarct-related coronary artery patency IRA. Methods: The NPAR ratio was calculated based on the past laboratory findings of patients admitted with ACS who underwent coronary angiography CAG, which were registered in the data system at the time of admission. A total of 87 patients were included in the study. Of these patients, 62 71 were non-patent and 25 29 were patent IRA patients. Results: NPAR was significantly higher in the non-patent group 19.223.14 and 17.142.78 p0.004. In multivariable logistic regression analysis, NPAR p0.027, odds ratio OR: 0.787, 95 confidence intervals CIs: 0.637-0.974 levels were found to be independent predictors of patent IRA. As revealed by the ROC curve analysis, the cut-off value of 17.88 for NPAR predicted the non-patent IRA with a sensitivity of 64 and specificity of 64 AUC: 0.681; CIs: 0.588-0.809; p0.008 NPAR was significantly higher in the MACE group 22.833.85 and 17.952.49 p0.001. Conclusion: In conclusion, inflammatory markers have been and are being used as predictive parameters for cardiovascular diseases in many studies. In our study, we focused on neutrophils and albumin. These findings revealed that NPAR is a independent predictor of IRA patency and long term mortality. We also indicated that NPAR may have a predictive role for mortality in the long-term follow-up of ACS patients.

 Aims: One of the leading causes of death and disease burden globally is coronary heart disease CHD. The primary cause of acute coronary syndrome ACS is atherosclerotic plaque rupture and thrombus development. The prognosis of ACS patients is also linked to atherosclerotic plaques, inflammatory cell infiltration lymphocytes, monocytes, and neutrophils, and inflammation indicators. Low serum albumin SA levels have been linked to death in ACS patients in earlier research. In our study, we aimed to investigate the association of neutrophil percentage-to-albumin ratio NPAR with infarct-related adverse cardiac events MACE and infarct-related coronary artery patency IRA. Methods: The NPAR ratio was calculated based on the past laboratory findings of patients admitted with ACS who underwent coronary angiography CAG, which were registered in the data system at the time of admission. A total of 87 patients were included in the study. Of these patients, 62 71 were non-patent and 25 29 were patent IRA patients. Results: NPAR was significantly higher in the non-patent group 19.223.14 and 17.142.78 p0.004. In multivariable logistic regression analysis, NPAR p0.027, odds ratio OR: 0.787, 95 confidence intervals CIs: 0.637-0.974 levels were found to be independent predictors of patent IRA. As revealed by the ROC curve analysis, the cut-off value of 17.88 for NPAR predicted the non-patent IRA with a sensitivity of 64 and specificity of 64 AUC: 0.681; CIs: 0.588-0.809; p0.008 NPAR was significantly higher in the MACE group 22.833.85 and 17.952.49 p0.001. Conclusion: In conclusion, inflammatory markers have been and are being used as predictive parameters for cardiovascular diseases in many studies. In our study, we focused on neutrophils and albumin. These findings revealed that NPAR is a independent predictor of IRA patency and long term mortality. We also indicated that NPAR may have a predictive role for mortality in the long-term follow-up of ACS patients.

 Giriş: Dünya genelinde ölüm ve hastalık yükünün önde gelen nedenlerinden biri koroner kalp hastalığıdır KKH. AKSnin birincil nedeni aterosklerotik plak rüptürü ve trombüs gelişimidir. AKS hastalarının prognozu ayrıca aterosklerotik plaklar, enflamatuar hücre infiltrasyonu lenfositler, monositler ve nötrofiller ve enflamasyon göstergeleri ile bağlantılıdır. Daha önceki araştırmalarda düşük serum albümin düzeyleri AKS hastalarında ölümle ilişkilendirilmiştir. Çalışmamızda, NPARın infarktla ilişkili advers kardiyak olaylar MACE ve infarktla ilişkili koroner arter açıklığı IRA ile ilişkisini araştırmayı amaçladık. Yöntem: NPAR oranı, xxx Eğitim ve Araştırma Hastanesine AKS ile başvuran ve koroner anjiyografi KAG yapılan hastaların başvuru sırasında veri sisteminde kayıtlı olan geçmiş laboratuvar bulgularına dayanarak hesaplandı. Çalışmaya toplam 87 hasta dahil edilmiştir. Bu hastaların 62si 71 patent olmayan ve 25i 29 patent IRA hastasıydı. Sonuçlar: NPAR patenti olmayan grupta anlamlı olarak daha yüksekti 19.223.14 ve 17.142.78 p0.004. Çok değişkenli lojistik regresyon analizinde, NPAR p 0.027, Odds Oranı OR: 0.787, 95 Güven Aralığı CIs: 0.637-0.974 düzeylerinin patent IRAnın bağımsız öngördürücüleri olduğu bulunmuştur.

Article Details

The relationship between neutrophil percentage-to-albumin ratio and infarct related artery patency in patients with acute coronary syndrome

Authors:

Alkame Akgümüş | Ali Duygu | Ahmet Balun

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Kardiyoloji

Journal:

Journal of Health Sciences and Medicine Vol.8 Issue 2, pp.333-337

Document Type:

Article

Publication Date:

3/2025

Document Language:

English

Document ID (Org No.):

2001343101

pISSN:

2636-8579

Neutrophil

albumin

infarct related artery

acute coronary syndromenötrofil

albümin

enfarkt ilişkili arter

akut koroner sendrom

Issues

Article Details

Authors: Alkame Akgümüş | Ali Duygu | Ahmet Balun

Publisher: MediHealth Academy Yayıncılık

Main Topics: Kardiyoloji

Journal: Journal of Health Sciences and Medicine Vol.8 Issue 2, pp.333-337

Document Type: Article

Publication Date: 3/2025

Document Language: English

Document ID (Org No.): 2001343101

pISSN: 2636-8579

Issues

Authors:

Alkame Akgümüş | Ali Duygu | Ahmet Balun

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Kardiyoloji

Journal:

Journal of Health Sciences and Medicine Vol.8 Issue 2, pp.333-337

Document Type:

Article

Publication Date:

3/2025

Document Language:

English

Document ID (Org No.):

2001343101

pISSN:

2636-8579