Comparison of different endometrial preparation protocols in frozen-thawed embryo transfer cycles in women with polycystic ovary syndrome

Murat Önal; Mehmet Ağar; Ayşe Şeyma Küçükakça; Tuğba Gürbüz

Article Details

Comparison of different endometrial preparation protocols in frozen-thawed embryo transfer cycles in women with polycystic ovary syndrome

Authors:

Murat Önal | Mehmet Ağar | Ayşe Şeyma Küçükakça | Tuğba Gürbüz

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Sağlık Kurumları Yönetimi

Journal:

Anatolian Current Medical Journal Vol.5 Issue 1, pp.34-38

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001282650

pISSN:

2718-0115

Keywords:

Abstract:

 Aim: This study aimed to evaluate the most suitable endometrial preparation protocols such as hormone replacement therapy HRT with gonadotropin releasing hormone analogue GnRH-a suppression, HRT without GnRH-a suppression and mild ovarian stimulation OS for women with polycystic ovary syndrome PCOS undergoing frozen-thawed embryo transfer FET. Material and Method: We conducted a historical cohort analysis of 161 women with PCOS who underwent the freeze-all strategy between December 2018 and August 2020 because of their high risk for ovarian hyperstimulation syndrome. Three endometrial preparation protocols were used: HRT with GnRH-a suppression n43; HRT without GnRH-a suppression n86; mild-OS n32. Results: The biochemical pregnancy results 55.8  vs 54.65  vs 53, p0.900, ongoing pregnancy rates 44.2  vs 43  vs 40.62, p0.572, and abort rates 20.8  vs 21.3  vs 23.52, p0.900 were similar between the HRT with GnRH-a suppression, without GnRH-a suppression and mild-OS, respectively. This study showed no statistically significant difference between the three protocols in laboratory parameters p0.05. Conclusion: There was no statistically difference between three groups in terms of pregnancy outcomes. Dependent on clinical experience and facility, one of these protocols could be deployed for FET in women with PCOS.

 Aim: This study aimed to evaluate the most suitable endometrial preparation protocols such as hormone replacement therapy HRT with gonadotropin releasing hormone analogue GnRH-a suppression, HRT without GnRH-a suppression and mild ovarian stimulation OS for women with polycystic ovary syndrome PCOS undergoing frozen-thawed embryo transfer FET. Material and Method: We conducted a historical cohort analysis of 161 women with PCOS who underwent the freeze-all strategy between December 2018 and August 2020 because of their high risk for ovarian hyperstimulation syndrome. Three endometrial preparation protocols were used: HRT with GnRH-a suppression n43; HRT without GnRH-a suppression n86; mild-OS n32. Results: The biochemical pregnancy results 55.8  vs 54.65  vs 53, p0.900, ongoing pregnancy rates 44.2  vs 43  vs 40.62, p0.572, and abort rates 20.8  vs 21.3  vs 23.52, p0.900 were similar between the HRT with GnRH-a suppression, without GnRH-a suppression and mild-OS, respectively. This study showed no statistically significant difference between the three protocols in laboratory parameters p0.05. Conclusion: There was no statistically difference between three groups in terms of pregnancy outcomes. Dependent on clinical experience and facility, one of these protocols could be deployed for FET in women with PCOS.

 Aim: This study aimed to evaluate the most suitable endometrial preparation protocols such as hormone replacement therapy HRT with gonadotropin releasing hormone analogue GnRH-a suppression, HRT without GnRH-a suppression and mild ovarian stimulation OS for women with polycystic ovary syndrome PCOS undergoing frozen-thawed embryo transfer FET. Material and Method: We conducted a historical cohort analysis of 161 women with PCOS who underwent the freeze-all strategy between December 2018 and August 2020 because of their high risk for ovarian hyperstimulation syndrome. Three endometrial preparation protocols were used: HRT with GnRH-a suppression n43; HRT without GnRH-a suppression n86; mild-OS n32. Results: The biochemical pregnancy results 55.8  vs 54.65  vs 53, p0.900, ongoing pregnancy rates 44.2  vs 43  vs 40.62, p0.572, and abort rates 20.8  vs 21.3  vs 23.52, p0.900 were similar between the HRT with GnRH-a suppression, without GnRH-a suppression and mild-OS, respectively. This study showed no statistically significant difference between the three protocols in laboratory parameters p0.05. Conclusion: There was no statistically difference between three groups in terms of pregnancy outcomes. Dependent on clinical experience and facility, one of these protocols could be deployed for FET in women with PCOS.

 Aim: This study aimed to evaluate the most suitable endometrial preparation protocols such as hormone replacement therapy HRT with gonadotropin releasing hormone analogue GnRH-a suppression, HRT without GnRH-a suppression and mild ovarian stimulation OS for women with polycystic ovary syndrome PCOS undergoing frozen-thawed embryo transfer FET. Material and Method: We conducted a historical cohort analysis of 161 women with PCOS who underwent the freeze-all strategy between December 2018 and August 2020 because of their high risk for ovarian hyperstimulation syndrome. Three endometrial preparation protocols were used: HRT with GnRH-a suppression n43; HRT without GnRH-a suppression n86; mild-OS n32. Results: The biochemical pregnancy results 55.8  vs 54.65  vs 53, p0.900, ongoing pregnancy rates 44.2  vs 43  vs 40.62, p0.572, and abort rates 20.8  vs 21.3  vs 23.52, p0.900 were similar between the HRT with GnRH-a suppression, without GnRH-a suppression and mild-OS, respectively. This study showed no statistically significant difference between the three protocols in laboratory parameters p0.05. Conclusion: There was no statistically difference between three groups in terms of pregnancy outcomes. Dependent on clinical experience and facility, one of these protocols could be deployed for FET in women with PCOS.

Article Details

Comparison of different endometrial preparation protocols in frozen-thawed embryo transfer cycles in women with polycystic ovary syndrome

Authors:

Murat Önal | Mehmet Ağar | Ayşe Şeyma Küçükakça | Tuğba Gürbüz

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Sağlık Kurumları Yönetimi

Journal:

Anatolian Current Medical Journal Vol.5 Issue 1, pp.34-38

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001282650

pISSN:

2718-0115

Frozen-thawed embryo

GnRH-a

implantation

polycystic ovary syndrome

Frozen-thawed embryo

GnRH-a

implantation

polycystic ovary syndrome

Issues

Article Details

Authors: Murat Önal | Mehmet Ağar | Ayşe Şeyma Küçükakça | Tuğba Gürbüz

Publisher: MediHealth Academy Yayıncılık

Main Topics: Sağlık Kurumları Yönetimi

Journal: Anatolian Current Medical Journal Vol.5 Issue 1, pp.34-38

Document Type: Article

Publication Date: 1/2023

Document Language: English

Document ID (Org No.): 2001282650

pISSN: 2718-0115

Issues

Authors:

Murat Önal | Mehmet Ağar | Ayşe Şeyma Küçükakça | Tuğba Gürbüz

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Sağlık Kurumları Yönetimi

Journal:

Anatolian Current Medical Journal Vol.5 Issue 1, pp.34-38

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001282650

pISSN:

2718-0115