Plasma Homocysteine and other Biochemical Parameters in Gestational Diabetes Mellitus

Gomathi , K. G.; Shaafie , I. A.; Khan , N.

Article Details

Plasma Homocysteine and other Biochemical Parameters in Gestational Diabetes Mellitus

Authors:

Gomathi , K. G. | Shaafie , I. A. | Khan , N.

Publisher:

medi+WORLD International

Main Topics:

Medicine

Journal:

World Family Medicine Journal: Incorporating the Middle East Journal of Family Medicine 2011 vol.9 Issue 8, pp.19-25

Document Type:

Article

Publication Date:

10/2011

Document Language:

English

Document ID (Org No.):

18421

Frequency:

Monthly

eISSN:

18390196

pISSN:

18390188

Descriptors:

Keywords:

Abstract:

 Objectives: This prospective case control study was conducted to compare levels of Homocysteine and other biochemical parameters in women diagnosed with Gestational Diabetes Mellitus (GDM) with that in normal pregnant women.
Design and settings: GDM was confirmed by the oral glucose tolerance test. Normal pregnant women served as the control group.
Subjects: A total of 62 pregnant women with uncomplicated pregnancies, between 24 and 28 weeks of gestation, were included in the study.
Interventions: Each woman was tested for plasma Glucose (GLU), plasma total Homocysteine (Hcy), serum Cholesterol (Chol), Triacylglycerol (TG), Uric acid (UA) and Creatinine (CRE) concentrations.
Results: Fasting plasma Glucose level and Body Mass Index of the GDM group was significantly higher compared to the control group. Total serum Cholesterol level was found to be significantly higher (P<0.001) in GDM compared to controls. Serum Triacylglycerol, Uric acid and Creatinine were also significantly elevated (P<0.001) in the GDM group compared to controls even though all values lay within the normal reference ranges. Hcy level in GDM was significantly higher compared to controls (P<0.001). Homocysteine, Cholesterol, Triacylglycerol, Uric acid and Creatinine levels were significantly elevated in GDM compared to normal pregnant women. Hcy correlated strongly with the fasting glucose levels (r = 0.9).

Article Details

Plasma Homocysteine and other Biochemical Parameters in Gestational Diabetes Mellitus

Authors:

Gomathi , K. G. | Shaafie , I. A. | Khan , N.

Publisher:

medi+WORLD International

Main Topics:

Medicine

Journal:

World Family Medicine Journal: Incorporating the Middle East Journal of Family Medicine 2011 vol.9 Issue 8, pp.19-25

Document Type:

Article

Publication Date:

10/2011

Document Language:

English

Document ID (Org No.):

18421

Frequency:

Monthly

eISSN:

18390196

pISSN:

18390188

Descriptors:

DIABETES

PREGNANCY

BIOCHEMICALS

GLUCOSE LEVEL

CHOLESTEROL

PREGNANT WOMEN

Gestational Diabetes

Homocysteine

Cholesterol

Triacylglycerol

Uric acid

Issues

Article Details

Authors: Gomathi , K. G. | Shaafie , I. A. | Khan , N.

Publisher: medi+WORLD International

Main Topics: Medicine

Journal: World Family Medicine Journal: Incorporating the Middle East Journal of Family Medicine 2011 vol.9 Issue 8, pp.19-25

Document Type: Article

Publication Date: 10/2011

Document Language: English

Document ID (Org No.): 18421

Frequency: Monthly

eISSN: 18390196

pISSN: 18390188

Descriptors:

Issues

Authors:

Gomathi , K. G. | Shaafie , I. A. | Khan , N.

Publisher:

medi+WORLD International

Main Topics:

Medicine

Journal:

World Family Medicine Journal: Incorporating the Middle East Journal of Family Medicine 2011 vol.9 Issue 8, pp.19-25

Document Type:

Article

Publication Date:

10/2011

Document Language:

English

Document ID (Org No.):

18421

Frequency:

Monthly

eISSN:

18390196

pISSN:

18390188