Clinical and Rhinoscintigraphic Evaluation of Oral Macrolides in the Management of Sinonasal Polyposis

Emine AYDIN; Hülya ORTAPAMUK; Hakan KORKMAZ; Engin DURSUN; Adil ERYILMAZ; Güleser SAYLAM; Muharrem DAĞLI

Article Details

Clinical and Rhinoscintigraphic Evaluation of Oral Macrolides in the Management of Sinonasal Polyposis

Authors:

Emine AYDIN | Hülya ORTAPAMUK | Hakan KORKMAZ | Engin DURSUN | Adil ERYILMAZ | Güleser SAYLAM | Muharrem DAĞLI

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2008 Vol.38 Issue 5, pp.465-470

Document Type:

Article

Publication Date:

4/2008

Document Language:

Turkish

Document ID (Org No.):

2000755728

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Keywords:

Abstract:

 

Aim: To document the efficacy of low-dose long-term oral macrolide treatment in the management of sinonasal polyposis. The study was designed prospectively in a group of patients with sinonasal polyposis and negative history of surgery.   Materials and Methods: Ten patients were administered roxithromycin (RXM) 150 mg/day single oral dose for eight weeks. All patients underwent Tc-99m rhinoscintigraphic evaluation of mucociliary activity and endoscopic evaluation before and after the treatments. Response to treatment, in terms of rhinoscintigraphic and endoscopic improvement, was assessed.   Results: Of the 10 patients, 7 were male and 3 female, with an average age of 46 years (27-74). Following treatment, mucociliary transport time was significantly reduced (P < 0.05) and the polyps were clinically shrunk (P < 0.05).   Conclusions: It was determined that low-dose long-term oral macrolide treatment was effective in the management of sinonasal polyposis. Macrolides can be considered, as an alternative to or in conjunction with steroids, in the management of sinonasal polyposis.

 

Aim: To document the efficacy of low-dose long-term oral macrolide treatment in the management of sinonasal polyposis. The study was designed prospectively in a group of patients with sinonasal polyposis and negative history of surgery.   Materials and Methods: Ten patients were administered roxithromycin (RXM) 150 mg/day single oral dose for eight weeks. All patients underwent Tc-99m rhinoscintigraphic evaluation of mucociliary activity and endoscopic evaluation before and after the treatments. Response to treatment, in terms of rhinoscintigraphic and endoscopic improvement, was assessed.   Results: Of the 10 patients, 7 were male and 3 female, with an average age of 46 years (27-74). Following treatment, mucociliary transport time was significantly reduced (P < 0.05) and the polyps were clinically shrunk (P < 0.05).   Conclusions: It was determined that low-dose long-term oral macrolide treatment was effective in the management of sinonasal polyposis. Macrolides can be considered, as an alternative to or in conjunction with steroids, in the management of sinonasal polyposis.

Article Details

Clinical and Rhinoscintigraphic Evaluation of Oral Macrolides in the Management of Sinonasal Polyposis

Authors:

Emine AYDIN | Hülya ORTAPAMUK | Hakan KORKMAZ | Engin DURSUN | Adil ERYILMAZ | Güleser SAYLAM | Muharrem DAĞLI

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2008 Vol.38 Issue 5, pp.465-470

Document Type:

Article

Publication Date:

4/2008

Document Language:

Turkish

Document ID (Org No.):

2000755728

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Sinonasal polyp

nasal polyp

nasal polyposis

macrolide

rhinoscintigraphy

Issues

Article Details

Clinical and Rhinoscintigraphic Evaluation of Oral Macrolides in the Management of Sinonasal Polyposis

Authors: Emine AYDIN | Hülya ORTAPAMUK | Hakan KORKMAZ | Engin DURSUN | Adil ERYILMAZ | Güleser SAYLAM | Muharrem DAĞLI

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2008 Vol.38 Issue 5, pp.465-470

Document Type: Article

Publication Date: 4/2008

Document Language: Turkish

Document ID (Org No.): 2000755728

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Sinonasal polyp

nasal polyp

nasal polyposis

macrolide

rhinoscintigraphy

Issues

Authors:

Emine AYDIN | Hülya ORTAPAMUK | Hakan KORKMAZ | Engin DURSUN | Adil ERYILMAZ | Güleser SAYLAM | Muharrem DAĞLI

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2008 Vol.38 Issue 5, pp.465-470

Document Type:

Article

Publication Date:

4/2008

Document Language:

Turkish

Document ID (Org No.):

2000755728

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144