Phenolic compounds and bioactivity of Scorzonera pygmaea Sibth. & Sm. aerial parts: In vitro antioxidant, anti-inflammatory and antimicrobial activities

Hasan ŞAHİN; Aynur SARI; Nurten ÖZSOY; Berna ÖZBEK ÇELİK

Article Details

Phenolic compounds and bioactivity of Scorzonera pygmaea Sibth. & Sm. aerial parts: In vitro antioxidant, anti-inflammatory and antimicrobial activities

Authors:

Hasan ŞAHİN | Aynur SARI | Nurten ÖZSOY | Berna ÖZBEK ÇELİK

Publisher:

Istanbul University

Main Topics:

Pharmacology and therapeutics | Promotion of health

Journal:

İstanbul Journal of Pharmacy 2020 Vol.50 Issue 3, pp.294-299

Document Type:

Article

Publication Date:

12/2020

Document Language:

English

Document ID (Org No.):

2000512945

Frequency:

Monthly

eISSN:

2587-2087

Abstract:

 

Background and Aims: Scorzonera L. genus contains several medicinal and edible plants. Both roots and aerial parts of Scorzonera species are used. S. pygmaea is endemic to Turkey. In a previous study, nine phenolic compounds were reported from the roots of the plant alongside certain biological activities. The current study was designed to investigate the aerial parts of the plant in the same manner and compare the potentials of the two parts. Methods: Chromatographic and spectroscopic methods were used to isolate and identify the phenolics. Total phenolic contents were determined by Folin–Ciocalteu method. FRAP assay, anti-LPO, scavenging DPPH, ABTS and superoxide radicals were employed to evaluate the antioxidant activity. COX inhibition test and micro broth dilution technique were used for antiinflammatory and antimicrobial activities, respectively. Results: Seven phenolic compounds; thunberginol C (1), protocatechuic acid (2), chlorogenic acid methyl ester (3), cudrabibenzyl A (4), scorzocreticin (5), scorzocreticoside I (6) and II (7) were purified. All the compounds are new for the aerial parts of the plant and 2 is new for the genus. The aerial parts showed a high antioxidant capacity which correlated with its phenolic content. COX inhibitory activity was found to be lower compared to Indomethacin. Weak antimicrobial activity was determined against Staphylococcus aureus and S. epidermidis. Conclusion: Aerial parts possess significant/infrequent phenolics and the ethyl acetate (EtOAc) fraction of the ethanol extract is the most promising fraction for isolating these compounds. Phenolic compositions of aerial parts and roots are very similar. However, aerial parts can be a better rich source of natural antioxidants with protocatechuic acid and higher antioxidant potential.

Article Details

Phenolic compounds and bioactivity of Scorzonera pygmaea Sibth. & Sm. aerial parts: In vitro antioxidant, anti-inflammatory and antimicrobial activities

Authors: Hasan ŞAHİN | Aynur SARI | Nurten ÖZSOY | Berna ÖZBEK ÇELİK

Publisher: Istanbul University

Main Topics: Pharmacology and therapeutics | Promotion of health

Journal: İstanbul Journal of Pharmacy 2020 Vol.50 Issue 3, pp.294-299

Document Type: Article

Publication Date: 12/2020

Document Language: English

Document ID (Org No.): 2000512945

Frequency: Monthly

eISSN: 2587-2087

Issues

Authors:

Hasan ŞAHİN | Aynur SARI | Nurten ÖZSOY | Berna ÖZBEK ÇELİK

Publisher:

Istanbul University

Main Topics:

Pharmacology and therapeutics | Promotion of health

Journal:

İstanbul Journal of Pharmacy 2020 Vol.50 Issue 3, pp.294-299

Document Type:

Article

Publication Date:

12/2020

Document Language:

English

Document ID (Org No.):

2000512945

Frequency:

Monthly

eISSN:

2587-2087