Acute Chest Syndrome Does Not Have a Chronic Inflammatory Background in Sickle Cell Diseases

Mehmet Rami Helvaci; Mustafa Sahan; Nesrin Atci; Orhan Ayyildiz; Orhan Ekrem Muftuoglu; Lesley Pocock

doi:10.5742/MEIM.2016.92862

Article Details

Acute Chest Syndrome Does Not Have a Chronic Inflammatory Background in Sickle Cell Diseases

Authors:

Mehmet Rami Helvaci | Mustafa Sahan | Nesrin Atci | Orhan Ayyildiz | Orhan Ekrem Muftuoglu | Lesley Pocock

Publisher:

medi+WORLD International

Main Topics:

Medicine

Journal:

Middle East Journal of Internal Medicine 2016 Vol.9 Issue 2, pp.12-18

Document Type:

Article

Publication Date:

8/2016

Document Language:

English

Document ID (Org No.):

93046

Frequency:

Quarterly

eISSN:

18379060

pISSN:

18379052

DOI:

10.5742/MEIM.2016.92862

Descriptors:

Keywords:

Abstract:

 Background: Sickle cell diseases (SCDs) are chronic catastrophic processes on vascular endothelium initiating at birth all over the body. We tried to understand whether or not there is a chronic inflammatory background of acute chest syndrome (ACS) in the SCDs.Methods: All patients with the SCDs were taken into the study.Results: The study included 411 patients (199 females). As one of the significant endpoints of SCDs, patients with chronic obstructive pulmonary disease (COPD) and without were collected into two groups. There were 60 patients (14.5%) with COPD. Mean age (33.0 versus 29.5 years, P=0.005) and male ratio (80.0% versus 46.7%, P<0.001) were higher in the COPD group. Smoking (36.6% versus 9.9%, P<0.001) and alcohol (3.3% versus 0.8%, P<0.05) were also higher among the COPD cases. Transfused red blood cell units in their lives (69.1 versus 32.9, P=0.001), priapism (10.0% versus 1.9%, P<0.001), leg ulcers (26.6% versus 11.6%, P<0.001), digital clubbing (25.0% versus 7.1%, P<0.001), coronary heart disease (26.6% versus 13.1%, P<0.01), chronic renal disease (16.6% versus 7.1%, P<0.01), and stroke (20.0% versus 7.9%, P<0.001) were all higher among the COPD cases, too. Interestingly, against the higher rates of the above problems in the COPD group, incidence of ACS was even lower among them, nonsignificantly (1.6% versus 3.9%, P>0.05).Conclusion: SCDs cause severe chronic endothelial damage particularly at the capillary level, and terminate with accelerated atherosclerosis induced end-organ failures in early years of life. Probably ACS is a sudden onset event without any chronic inflammatory background in the SCDs.

Article Details

Acute Chest Syndrome Does Not Have a Chronic Inflammatory Background in Sickle Cell Diseases

Authors:

Mehmet Rami Helvaci | Mustafa Sahan | Nesrin Atci | Orhan Ayyildiz | Orhan Ekrem Muftuoglu | Lesley Pocock

Publisher:

medi+WORLD International

Main Topics:

Medicine

Journal:

Middle East Journal of Internal Medicine 2016 Vol.9 Issue 2, pp.12-18

Document Type:

Article

Publication Date:

8/2016

Document Language:

English

Document ID (Org No.):

93046

Frequency:

Quarterly

eISSN:

18379060

pISSN:

18379052

DOI:

10.5742/MEIM.2016.92862

Descriptors:

SICKLE CELL DISEASES

CHRONIC DISEASES

ENDOTHELIAL CELLS

PATIENTS

Sickle Cell Diseases

Acute Chest Syndrome

Chronic Endothelial Damage

Issues

Article Details

Authors: Mehmet Rami Helvaci | Mustafa Sahan | Nesrin Atci | Orhan Ayyildiz | Orhan Ekrem Muftuoglu | Lesley Pocock

Publisher: medi+WORLD International

Main Topics: Medicine

Journal: Middle East Journal of Internal Medicine 2016 Vol.9 Issue 2, pp.12-18

Document Type: Article

Publication Date: 8/2016

Document Language: English

Document ID (Org No.): 93046

Frequency: Quarterly

eISSN: 18379060

pISSN: 18379052

DOI: 10.5742/MEIM.2016.92862

Descriptors:

Issues

Authors:

Mehmet Rami Helvaci | Mustafa Sahan | Nesrin Atci | Orhan Ayyildiz | Orhan Ekrem Muftuoglu | Lesley Pocock

Publisher:

medi+WORLD International

Main Topics:

Medicine

Journal:

Middle East Journal of Internal Medicine 2016 Vol.9 Issue 2, pp.12-18

Document Type:

Article

Publication Date:

8/2016

Document Language:

English

Document ID (Org No.):

93046

Frequency:

Quarterly

eISSN:

18379060

pISSN:

18379052

DOI:

10.5742/MEIM.2016.92862