Immune-Mediated Multi-Organ SyndromesDiagnostic Challenges and the Role of Artificial Intelligence in Internal Medicine

لعرباني سليم; Pr Lyazidi Nabila; Pr Ayoub Soraya

Article Details

Immune-Mediated Multi-Organ SyndromesDiagnostic Challenges and the Role of Artificial Intelligence in Internal Medicine

Authors:

لعرباني سليم | Pr Lyazidi Nabila | Pr Ayoub Soraya

Publisher:

Université Benyoucef Benkhedda d'Alger

Journal:

REVUE ALGERIENNE D’ALLERGOLOGIE Vol.10 Issue 2, pp.10-16

Document Type:

Article

Publication Date:

1/2026

Document Language:

English

Document ID (Org No.):

2001544519

pISSN:

2710-8317

Keywords:

Abstract:

 Immune-mediated multi-organ syndromes pose significant diagnostic difficulties in internal medicine, especially when clinical presentations are atypical or overlap multiple disease entities. Syndromes such as mixed connective tissue disease (MCTD) and anti-synthetase syndrome (ASS) embody this complexity, often blending signs of systemic lupus erythematosus, systemic sclerosis, myositis, and other connective tissue diseases. The boundaries between these syndromes remain poorly defined, leading to diagnostic delays and therapeutic uncertainty.
Amid this diagnostic chaos, artificial intelligence (AI) offers a compelling solution. By leveraging machine learning techniques, AI can synthesize vast clinical and biological datasets to generate predictive models and aid diagnostic reasoning. This review examines the clinical and immunological characteristics of key overlap syndromes, dissects the limitations of current diagnostic frameworks, and explores how AI can support internists in managing these challenging cases. A conceptual diagnostic decision tree incorporating AI-supported logic is presented to illustrate how such systems could enhance diagnostic accuracy, reduce time to diagnosis, and promote earlier therapeutic interventions.

Article Details

Immune-Mediated Multi-Organ SyndromesDiagnostic Challenges and the Role of Artificial Intelligence in Internal Medicine

Authors:

لعرباني سليم | Pr Lyazidi Nabila | Pr Ayoub Soraya

Publisher:

Université Benyoucef Benkhedda d'Alger

Journal:

REVUE ALGERIENNE D’ALLERGOLOGIE Vol.10 Issue 2, pp.10-16

Document Type:

Article

Publication Date:

1/2026

Document Language:

English

Document ID (Org No.):

2001544519

pISSN:

2710-8317

Autoimmune diseases

overlap syndromes

artificial intelligence

internal medicine

diagnosis

connective tissue disorders

anti-synthetase syndrome

systemic autoimmunity

Issues

Article Details

Authors: لعرباني سليم | Pr Lyazidi Nabila | Pr Ayoub Soraya

Publisher: Université Benyoucef Benkhedda d'Alger

Journal: REVUE ALGERIENNE D’ALLERGOLOGIE Vol.10 Issue 2, pp.10-16

Document Type: Article

Publication Date: 1/2026

Document Language: English

Document ID (Org No.): 2001544519

pISSN: 2710-8317

Issues

Authors:

لعرباني سليم | Pr Lyazidi Nabila | Pr Ayoub Soraya

Publisher:

Université Benyoucef Benkhedda d'Alger

Journal:

REVUE ALGERIENNE D’ALLERGOLOGIE Vol.10 Issue 2, pp.10-16

Document Type:

Article

Publication Date:

1/2026

Document Language:

English

Document ID (Org No.):

2001544519

pISSN:

2710-8317