COBALT AND ASCORBIC ACID TREATMENT: EFFECTS ON  TISSUE NITRIC OXIDE LEVELS IN STREPTOZOTOCIN- DIABETIC RAT

Özlem YILDIRIM

Article Details

COBALT AND ASCORBIC ACID TREATMENT: EFFECTS ON TISSUE NITRIC OXIDE LEVELS IN STREPTOZOTOCIN- DIABETIC RAT

Authors:

Özlem YILDIRIM

Publisher:

Ankara University

Journal:

Communications Faculty of Sciences University of Ankara Series C Biology 2010 Vol.22 Issue 1, pp.1-14

Document Type:

Article

Publication Date:

5/2010

Document Language:

English

Document ID (Org No.):

2000911357

Frequency:

Monthly

eISSN:

2651-3749

pISSN:

1303-6025

Abstract:

 

The aim of present study was to determine the effect of cobalt (II) chloride (CoCl2) and CoCl2plus ascorbic acid (AA) on liver and kidney nitric oxide level at different stage of diabetes. Three days after streptozotocin (STZ) injection, rats were divided into six groups: control, diabetic, control and diabetic treated with cobalt chloride, control and diabetics treated with cobalt chloride plus ascorbic acid. 0.5 mM CoCl2  or 0.5 mM CoCl2 plus 1 g/l ascorbic acid were added to their drinking water daily. At the end of the second, fourth and sixth week of the treatment all animals were sacrified by decapitation. Liver and kidney tissues were removed for the determination of nitric oxide (NO) levels. Cobalt treatment effectively decreased the nitric oxide levels both in liver and kidney tissues of diabetic rats. Thus, the effect of oral administration of cobalt treatment may prove effective in improving the impaired nitrite status during the early stage of diabetes and ascorbic acid supplementation at this dose (1g/l) potentiates the effectiveness of cobalt action.

Article Details

COBALT AND ASCORBIC ACID TREATMENT: EFFECTS ON TISSUE NITRIC OXIDE LEVELS IN STREPTOZOTOCIN- DIABETIC RAT

Authors: Özlem YILDIRIM

Publisher: Ankara University

Journal: Communications Faculty of Sciences University of Ankara Series C Biology 2010 Vol.22 Issue 1, pp.1-14

Document Type: Article

Publication Date: 5/2010

Document Language: English

Document ID (Org No.): 2000911357

Frequency: Monthly

eISSN: 2651-3749

pISSN: 1303-6025

Issues

Authors:

Özlem YILDIRIM

Publisher:

Ankara University

Journal:

Communications Faculty of Sciences University of Ankara Series C Biology 2010 Vol.22 Issue 1, pp.1-14

Document Type:

Article

Publication Date:

5/2010

Document Language:

English

Document ID (Org No.):

2000911357

Frequency:

Monthly

eISSN:

2651-3749

pISSN:

1303-6025