Hypoglycemic and Hepatoprotective Effects of Foeniculum vulgare Miller Seed Fixed Oil Extract inMice and Rats

HANEFİ ÖZBEK; Mustafa ÖZTÜRK; İrfan BAYRAM; Serdar UĞRAŞ; GÜLÇİN SALTAN ÇİTOĞLU

Article Details

Hypoglycemic and Hepatoprotective Effects of Foeniculum vulgare Miller Seed Fixed Oil Extract inMice and Rats

Authors:

HANEFİ ÖZBEK | Mustafa ÖZTÜRK | İrfan BAYRAM | Serdar UĞRAŞ | GÜLÇİN SALTAN ÇİTOĞLU

Publisher:

Van Yuzuncu Yıl University

Journal:

EASTERN JOURNAL OF MEDICINE 2003 Vol.8 Issue 2, pp.35-40

Document Type:

Article

Publication Date:

2/2013

Document Language:

English

Document ID (Org No.):

2000773425

Frequency:

Monthly

eISSN:

1301-0883

pISSN:

1301-0883

Abstract:

 

Objective: We aimed to investigate median lethal dose(LD50) and hypoglycemic effect of fixed oil ofFoeniculum vulgare Miller seed fixed oil (FFO) in miceand its hepatoprotective effect on carbon tetrachloride(CCl4) induced liver injury model in rats.Method: Extract of FFO, glibenclamide (as a referencegroup) and physiologic saline (control group) wereadministrated to the healthy and diabet occured micewith alloxan. Before treatment in the first, second, third,fourth and 24th hours, blood was taken from the venacoccygea of mice. Blood glucose levels weremeasured.Twenty-four Sprague-Dawley rats were divided intofour groups (n=6), and the groups treated daily forseven days, by i.p. injections, of isotonic saline solution(ISS), olive oil, carbon tetrachloride (CCl4), CCl4 + FFOrespectively.Results:  FFO did not significantly reduced bloodglucose in alloxane-induced diabetic mice comparedto ISS control group. In contrast, glibenclamideeffectively reduced blood glucose of alloxane-inducedmice in first, second, fourth and 24th hours as expected.In the CCl4-treated group and FFO-treated group serumaspartate aminotransferase (AST), alanineaminotransferase (ALT) and alkaline phosphatase(ALP) levels were quite high. In contrast, the controlgroups (group I and group II) had significantly lowerlevels of AST and ALT when compared with the CCl4and FFO groups.Conclusion: The results of this study indicate that FFOhas neither a potent hepatoprotective effect againstCCl4-induced hepatic damage in rats nor ahypoglycemic action in mice. The LD50 of FFO wasdetermined as 5.52 mL/kg.Key words: Foeniculum vulgare Miller, fennel fixed oil,median lethal dose, hepatoprotective effect, hypoglycemiceffect.

Article Details

Hypoglycemic and Hepatoprotective Effects of Foeniculum vulgare Miller Seed Fixed Oil Extract inMice and Rats

Authors: HANEFİ ÖZBEK | Mustafa ÖZTÜRK | İrfan BAYRAM | Serdar UĞRAŞ | GÜLÇİN SALTAN ÇİTOĞLU

Publisher: Van Yuzuncu Yıl University

Journal: EASTERN JOURNAL OF MEDICINE 2003 Vol.8 Issue 2, pp.35-40

Document Type: Article

Publication Date: 2/2013

Document Language: English

Document ID (Org No.): 2000773425

Frequency: Monthly

eISSN: 1301-0883

pISSN: 1301-0883

Issues

Authors:

HANEFİ ÖZBEK | Mustafa ÖZTÜRK | İrfan BAYRAM | Serdar UĞRAŞ | GÜLÇİN SALTAN ÇİTOĞLU

Publisher:

Van Yuzuncu Yıl University

Journal:

EASTERN JOURNAL OF MEDICINE 2003 Vol.8 Issue 2, pp.35-40

Document Type:

Article

Publication Date:

2/2013

Document Language:

English

Document ID (Org No.):

2000773425

Frequency:

Monthly

eISSN:

1301-0883

pISSN:

1301-0883