Etofenamate and anastomoses of the colon in rats

Aydın İNAN

Article Details

Etofenamate and anastomoses of the colon in rats

Authors:

Aydın İNAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 5, pp.713-718

Document Type:

Article

Publication Date:

4/2009

Document Language:

Turkish

Document ID (Org No.):

2000755314

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Keywords:

Abstract:

 

Aim: Non-steroidal anti-inflammatory drugs have been used for many years due to their analgesic and anti-inflammatory properties. They have also been used for postoperative analgesia. We aimed to study the effects of etofenamate, a non-steroidal anti-inflammatory drug, on the healing of colonic anastomoses in rats.  Materials and methods: Sprague-Dawley rats were used in this study. Resection and anastomosis were performed on the distal colon. The etofenamate group received 30 mg/kg etofenamate and the control group received 0.1 mL of 0.9% NaCl intramuscularly daily. Bursting pressures of anastomoses and hydroxyproline levels of perianastomotic tissues were determined on days 3 and 7.   Results: Four deaths were observed in each group. Mean bursting pressures (etofenamate group, day 3: 50.50 ± 7.27 mmHg, day 7: 187.37 ± 12.20 mmHg; control group, day 3: 55.13 ± 5.94 mmHg, day 7: 202.12 ± 18.64 mmHg) and mean hydroxyproline levels (etofenamate group, day 3: 2.18 ± 0.17 µg/mg tissue, day 7: 4.34 ± 0.79 µg/mg tissue; control group, day 3: 2.20 ± 0.12 µg/mg tissue, day 7: 5.07 ± 0.65 µg/mg tissue) in the etofenamate group were lower than those in the control group on both days 3 and 7. This finding was not statistically significant.  Conclusion: According to our findings, etofenamate treatment during the postoperative period does not alter the healing of colonic anastomoses in rats.

 

Aim: Non-steroidal anti-inflammatory drugs have been used for many years due to their analgesic and anti-inflammatory properties. They have also been used for postoperative analgesia. We aimed to study the effects of etofenamate, a non-steroidal anti-inflammatory drug, on the healing of colonic anastomoses in rats.  Materials and methods: Sprague-Dawley rats were used in this study. Resection and anastomosis were performed on the distal colon. The etofenamate group received 30 mg/kg etofenamate and the control group received 0.1 mL of 0.9% NaCl intramuscularly daily. Bursting pressures of anastomoses and hydroxyproline levels of perianastomotic tissues were determined on days 3 and 7.   Results: Four deaths were observed in each group. Mean bursting pressures (etofenamate group, day 3: 50.50 ± 7.27 mmHg, day 7: 187.37 ± 12.20 mmHg; control group, day 3: 55.13 ± 5.94 mmHg, day 7: 202.12 ± 18.64 mmHg) and mean hydroxyproline levels (etofenamate group, day 3: 2.18 ± 0.17 µg/mg tissue, day 7: 4.34 ± 0.79 µg/mg tissue; control group, day 3: 2.20 ± 0.12 µg/mg tissue, day 7: 5.07 ± 0.65 µg/mg tissue) in the etofenamate group were lower than those in the control group on both days 3 and 7. This finding was not statistically significant.  Conclusion: According to our findings, etofenamate treatment during the postoperative period does not alter the healing of colonic anastomoses in rats.

Article Details

Etofenamate and anastomoses of the colon in rats

Authors:

Aydın İNAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 5, pp.713-718

Document Type:

Article

Publication Date:

4/2009

Document Language:

Turkish

Document ID (Org No.):

2000755314

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Non-steroidal anti-inflammatory drugs

etofenamate

colon

anastomosis

healing

rat

Issues

Article Details

Etofenamate and anastomoses of the colon in rats

Authors: Aydın İNAN

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2009 Vol.39 Issue 5, pp.713-718

Document Type: Article

Publication Date: 4/2009

Document Language: Turkish

Document ID (Org No.): 2000755314

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Non-steroidal anti-inflammatory drugs

etofenamate

colon

anastomosis

healing

rat

Issues

Authors:

Aydın İNAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 5, pp.713-718

Document Type:

Article

Publication Date:

4/2009

Document Language:

Turkish

Document ID (Org No.):

2000755314

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144