Incompatibility Studies of Tamsulosin HCl using TGA, DSC and FT-IR

Alankar Shrivastava; Ashu Mıttal

Article Details

Incompatibility Studies of Tamsulosin HCl using TGA, DSC and FT-IR

Authors:

Alankar Shrivastava | Ashu Mıttal

Publisher:

Hacettepe University

Main Topics:

Pharmacology and Pharmaceutical Sciences

Journal:

Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 1, pp.22-31

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001284499

pISSN:

2458-8806

Keywords:

Abstract:

 The Benign Prostatic Hyperplasia is one of the common old age problems and alpha one adrenoreceptor blockers are commonly used for symptomatic relief. Tamsulosin HCl is selective alpha 1A adrenoreceptor blocker with better tolerability profile and once daily dosing advantage. The present study was undertaken to establish the compatibility of Tamsulosin with several commonly used excipients by using thermo analytical technique viz Thermogravimetry and differential scanning calorimetry used in formulation. The Thermogravimetry and differential scanning calorimetry both results demonstrated that ethyl cellulose, Gelatin and lactose found to be incompatible with Tamsulosin and should be avoided for the pharmaceutical preparation.

 The Benign Prostatic Hyperplasia is one of the common old age problems and alpha one adrenoreceptor blockers are commonly used for symptomatic relief. Tamsulosin HCl is selective alpha 1A adrenoreceptor blocker with better tolerability profile and once daily dosing advantage. The present study was undertaken to establish the compatibility of Tamsulosin with several commonly used excipients by using thermo analytical technique viz Thermogravimetry and differential scanning calorimetry used in formulation. The Thermogravimetry and differential scanning calorimetry both results demonstrated that ethyl cellulose, Gelatin and lactose found to be incompatible with Tamsulosin and should be avoided for the pharmaceutical preparation.

 The Benign Prostatic Hyperplasia is one of the common old age problems and alpha one adrenoreceptor blockers are commonly used for symptomatic relief. Tamsulosin HCl is selective alpha 1A adrenoreceptor blocker with better tolerability profile and once daily dosing advantage. The present study was undertaken to establish the compatibility of Tamsulosin with several commonly used excipients by using thermo analytical technique viz Thermogravimetry and differential scanning calorimetry used in formulation. The Thermogravimetry and differential scanning calorimetry both results demonstrated that ethyl cellulose, Gelatin and lactose found to be incompatible with Tamsulosin and should be avoided for the pharmaceutical preparation.

 The Benign Prostatic Hyperplasia is one of the common old age problems and alpha one adrenoreceptor blockers are commonly used for symptomatic relief. Tamsulosin HCl is selective alpha 1A adrenoreceptor blocker with better tolerability profile and once daily dosing advantage. The present study was undertaken to establish the compatibility of Tamsulosin with several commonly used excipients by using thermo analytical technique viz Thermogravimetry and differential scanning calorimetry used in formulation. The Thermogravimetry and differential scanning calorimetry both results demonstrated that ethyl cellulose, Gelatin and lactose found to be incompatible with Tamsulosin and should be avoided for the pharmaceutical preparation.

Article Details

Incompatibility Studies of Tamsulosin HCl using TGA, DSC and FT-IR

Authors:

Alankar Shrivastava | Ashu Mıttal

Publisher:

Hacettepe University

Main Topics:

Pharmacology and Pharmaceutical Sciences

Journal:

Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 1, pp.22-31

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001284499

pISSN:

2458-8806

Differential scanning calorimetry (DSC)

Thermogravimetry (TG)

Incompatibility study

Fourier transform Infra Red (FTIR)

Tamsulosin

Tamsulosin

Differential scanning calorimetry

Thermogravimetry

Incompatibility study

Fourier transform Infra Red

Issues

Article Details

Authors: Alankar Shrivastava | Ashu Mıttal

Publisher: Hacettepe University

Main Topics: Pharmacology and Pharmaceutical Sciences

Journal: Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 1, pp.22-31

Document Type: Article

Publication Date: 1/2023

Document Language: English

Document ID (Org No.): 2001284499

pISSN: 2458-8806

Issues

Authors:

Alankar Shrivastava | Ashu Mıttal

Publisher:

Hacettepe University

Main Topics:

Pharmacology and Pharmaceutical Sciences

Journal:

Hacettepe University Journal of the Faculty of Pharmacy Vol.43 Issue 1, pp.22-31

Document Type:

Article

Publication Date:

1/2023

Document Language:

English

Document ID (Org No.):

2001284499

pISSN:

2458-8806