The importance and prognostic effect of thyroid hormones in patients with transposition of the great arteries

Ergin Arslanoğlu

Article Details

The importance and prognostic effect of thyroid hormones in patients with transposition of the great arteries

Authors:

Ergin Arslanoğlu

Publisher:

Prusa Medical Publishing

Main Topics:

Cardiovascular Surgery

Journal:

The European Research Journal Vol.10 Issue 5, pp.465-473

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001325101

pISSN:

2149-3189

Keywords:

Abstract:

 Objectives: Transposition of the great arteries TGA is a rare congenital heart disease that occurs in 3 in 10,000 newborns and is rapidly fatal 90 within one year if left untreated. The prognosis of this pathology changed after introducing an early arterial switch operation ASO, while the left ventricle could still adapt to systemic high-pressure conditions. Appropriate regulation of thyroid hormones positively impacts metabolism, cardiac function, and postoperative recovery. Therefore, regular thyroid hormone monitoring and thyroid function monitoring of TGA patients may help to improve the health status and prognosis of this group of postoperative patients. Methods: In our study, 127 patients who underwent ASO at our pediatric cardiac surgery clinic between 01.01.2014 and 18.09.2021 were retrospectively analyzed and included. Among the patients, 43 n54 were females, and 57 n73 were males. Results: The coronary arteries were normal in 89.7 n114 and abnormal in 10.3 n13 of the patients. Twenty-one of the patients exited, and mortality was calculated to be 16.5. There were no significant differences in mortality or thyroid stimulating hormone TSH, free thyroxine T4, or free triiodothyronine T3 values P0.674, P0.345, P0.478. In our study, in which we investigated the effect of thyroid hormone levels on prognosis in neonatal patients with TGA with normal free T3, T4, and TSH values, we found that TSH levels were greater in the group with advanced aortic regurgitation and exitus, although the effect of thyroid hormones on postoperative results was not statistically significant. Conclusions: Congenital hypothyroidism is a common disease with cardiac effects. During the neonatal period, this disease may conceal itself. Careful, expert clinical follow-up and clinical trials are crucial to improve outcomes in the surgical treatment of transposition of the great arteries, a complex congenital heart disease.

 Objectives: Transposition of the great arteries TGA is a rare congenital heart disease that occurs in 3 in 10,000 newborns and is rapidly fatal 90 within one year if left untreated. The prognosis of this pathology changed after introducing an early arterial switch operation ASO, while the left ventricle could still adapt to systemic high-pressure conditions. Appropriate regulation of thyroid hormones positively impacts metabolism, cardiac function, and postoperative recovery. Therefore, regular thyroid hormone monitoring and thyroid function monitoring of TGA patients may help to improve the health status and prognosis of this group of postoperative patients. Methods: In our study, 127 patients who underwent ASO at our pediatric cardiac surgery clinic between 01.01.2014 and 18.09.2021 were retrospectively analyzed and included. Among the patients, 43 n54 were females, and 57 n73 were males. Results: The coronary arteries were normal in 89.7 n114 and abnormal in 10.3 n13 of the patients. Twenty-one of the patients exited, and mortality was calculated to be 16.5. There were no significant differences in mortality or thyroid stimulating hormone TSH, free thyroxine T4, or free triiodothyronine T3 values P0.674, P0.345, P0.478. In our study, in which we investigated the effect of thyroid hormone levels on prognosis in neonatal patients with TGA with normal free T3, T4, and TSH values, we found that TSH levels were greater in the group with advanced aortic regurgitation and exitus, although the effect of thyroid hormones on postoperative results was not statistically significant. Conclusions: Congenital hypothyroidism is a common disease with cardiac effects. During the neonatal period, this disease may conceal itself. Careful, expert clinical follow-up and clinical trials are crucial to improve outcomes in the surgical treatment of transposition of the great arteries, a complex congenital heart disease.

 Objectives: Transposition of the great arteries TGA is a rare congenital heart disease that occurs in 3 in 10,000 newborns and is rapidly fatal 90 within one year if left untreated. The prognosis of this pathology changed after introducing an early arterial switch operation ASO, while the left ventricle could still adapt to systemic high-pressure conditions. Appropriate regulation of thyroid hormones positively impacts metabolism, cardiac function, and postoperative recovery. Therefore, regular thyroid hormone monitoring and thyroid function monitoring of TGA patients may help to improve the health status and prognosis of this group of postoperative patients. Methods: In our study, 127 patients who underwent ASO at our pediatric cardiac surgery clinic between 01.01.2014 and 18.09.2021 were retrospectively analyzed and included. Among the patients, 43 n54 were females, and 57 n73 were males. Results: The coronary arteries were normal in 89.7 n114 and abnormal in 10.3 n13 of the patients. Twenty-one of the patients exited, and mortality was calculated to be 16.5. There were no significant differences in mortality or thyroid stimulating hormone TSH, free thyroxine T4, or free triiodothyronine T3 values P0.674, P0.345, P0.478. In our study, in which we investigated the effect of thyroid hormone levels on prognosis in neonatal patients with TGA with normal free T3, T4, and TSH values, we found that TSH levels were greater in the group with advanced aortic regurgitation and exitus, although the effect of thyroid hormones on postoperative results was not statistically significant. Conclusions: Congenital hypothyroidism is a common disease with cardiac effects. During the neonatal period, this disease may conceal itself. Careful, expert clinical follow-up and clinical trials are crucial to improve outcomes in the surgical treatment of transposition of the great arteries, a complex congenital heart disease.

 Objectives: Transposition of the great arteries TGA is a rare congenital heart disease that occurs in 3 in 10,000 newborns and is rapidly fatal 90 within one year if left untreated. The prognosis of this pathology changed after introducing an early arterial switch operation ASO, while the left ventricle could still adapt to systemic high-pressure conditions. Appropriate regulation of thyroid hormones positively impacts metabolism, cardiac function, and postoperative recovery. Therefore, regular thyroid hormone monitoring and thyroid function monitoring of TGA patients may help to improve the health status and prognosis of this group of postoperative patients. Methods: In our study, 127 patients who underwent ASO at our pediatric cardiac surgery clinic between 01.01.2014 and 18.09.2021 were retrospectively analyzed and included. Among the patients, 43 n54 were females, and 57 n73 were males. Results: The coronary arteries were normal in 89.7 n114 and abnormal in 10.3 n13 of the patients. Twenty-one of the patients exited, and mortality was calculated to be 16.5. There were no significant differences in mortality or thyroid stimulating hormone TSH, free thyroxine T4, or free triiodothyronine T3 values P0.674, P0.345, P0.478. In our study, in which we investigated the effect of thyroid hormone levels on prognosis in neonatal patients with TGA with normal free T3, T4, and TSH values, we found that TSH levels were greater in the group with advanced aortic regurgitation and exitus, although the effect of thyroid hormones on postoperative results was not statistically significant. Conclusions: Congenital hypothyroidism is a common disease with cardiac effects. During the neonatal period, this disease may conceal itself. Careful, expert clinical follow-up and clinical trials are crucial to improve outcomes in the surgical treatment of transposition of the great arteries, a complex congenital heart disease.

Article Details

The importance and prognostic effect of thyroid hormones in patients with transposition of the great arteries

Authors: Ergin Arslanoğlu

Publisher: Prusa Medical Publishing

Main Topics: Cardiovascular Surgery

Journal: The European Research Journal Vol.10 Issue 5, pp.465-473

Document Type: Article

Publication Date: 4/2024

Document Language: English

Document ID (Org No.): 2001325101

pISSN: 2149-3189

Transposition of the great arteries

arterial switch operation

thyroid hormones

thyroid stimulating hormone

Issues

Authors:

Ergin Arslanoğlu

Publisher:

Prusa Medical Publishing

Main Topics:

Cardiovascular Surgery

Journal:

The European Research Journal Vol.10 Issue 5, pp.465-473

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001325101

pISSN:

2149-3189