New determinants for causal neural mechanism of dry mouth in Parkinson’s disease induced by destruction of superior salivatory nucleus, facial nerve, and submandibular gland circuitry: an experimental study

Mete Zeynal

Article Details

New determinants for causal neural mechanism of dry mouth in Parkinson’s disease induced by destruction of superior salivatory nucleus, facial nerve, and submandibular gland circuitry: an experimental study

Authors:

Mete Zeynal

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Sağlık Kurumları Yönetimi

Journal:

Anatolian Current Medical Journal Vol.5 Issue 2, pp.153-159

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001286196

pISSN:

2718-0115

Keywords:

Abstract:

 Aim: Dry mouth has been considered a clinical finding of Parkinsons disease PD, but we think otherwise. We studied if the olfactory bulbectomy OBX might rely on the superior salivatory nucleus SSN, submandibular ganglia SMGn, and submandibular glands SLGl circuity disruption induced submandibular gland degeneration related dry mouth in rats. Material and Method: This study was carried out on twenty-six male rats. Five GI-n5, six GII, n6, and sixteen GIII, n15 of them were used as control, SHAM, and OBX groups, respectively, and followed eight weeks. PD-related clinical examinations were done before and after the experiment 1day, and animals were decapitated. The olfactory bulb volumes mm3, degenerated neuron densities of SSNSMG nmm3 and SMGl follicles volumes were detected serologically. Olfactory bulb volume values and degenerated neuron density values of SSNSMGnSMGl follicles volumes were compared statistically. Results: OBX-applied animals showed anosmia, tremors, rigidity, and memory loss. The mean olfactory bulb volumes mm3, degenerated neuron density of SSN nmm3, SMGn nmm3, and follicles volumes of SMGl cubic micrometermm3 were measured in the order written as; 4.270.21, 41, 52, 81.2313.34.106 in GI; 3.670.33, 143, 174, 72.4511.78.106 in GII and 2.910.14, 235, 298, 57.1911.93.106 in Group III. The mean P values between olfactory bulb volumes, degenerated neuron densities of SSN and SMGn, and salivary follicles volumes were: p0.005 in GIGII; p0.0005 in GIIGIII; p0.0001 in GIGIII. Conclusion: OBX-related olfactory network designalisation may be responsible for SSNSMGn circuitry degeneration-induced SMGl atrophy-based dry mouth. The OBX-related dry mouth should be considered a causative factor for Parkinsons disease, not a result.

 Aim: Dry mouth has been considered a clinical finding of Parkinsons disease PD, but we think otherwise. We studied if the olfactory bulbectomy OBX might rely on the superior salivatory nucleus SSN, submandibular ganglia SMGn, and submandibular glands SLGl circuity disruption induced submandibular gland degeneration related dry mouth in rats. Material and Method: This study was carried out on twenty-six male rats. Five GI-n5, six GII, n6, and sixteen GIII, n15 of them were used as control, SHAM, and OBX groups, respectively, and followed eight weeks. PD-related clinical examinations were done before and after the experiment 1day, and animals were decapitated. The olfactory bulb volumes mm3, degenerated neuron densities of SSNSMG nmm3 and SMGl follicles volumes were detected serologically. Olfactory bulb volume values and degenerated neuron density values of SSNSMGnSMGl follicles volumes were compared statistically. Results: OBX-applied animals showed anosmia, tremors, rigidity, and memory loss. The mean olfactory bulb volumes mm3, degenerated neuron density of SSN nmm3, SMGn nmm3, and follicles volumes of SMGl cubic micrometermm3 were measured in the order written as; 4.270.21, 41, 52, 81.2313.34.106 in GI; 3.670.33, 143, 174, 72.4511.78.106 in GII and 2.910.14, 235, 298, 57.1911.93.106 in Group III. The mean P values between olfactory bulb volumes, degenerated neuron densities of SSN and SMGn, and salivary follicles volumes were: p0.005 in GIGII; p0.0005 in GIIGIII; p0.0001 in GIGIII. Conclusion: OBX-related olfactory network designalisation may be responsible for SSNSMGn circuitry degeneration-induced SMGl atrophy-based dry mouth. The OBX-related dry mouth should be considered a causative factor for Parkinsons disease, not a result.

 Aim: Dry mouth has been considered a clinical finding of Parkinsons disease PD, but we think otherwise. We studied if the olfactory bulbectomy OBX might rely on the superior salivatory nucleus SSN, submandibular ganglia SMGn, and submandibular glands SLGl circuity disruption induced submandibular gland degeneration related dry mouth in rats. Material and Method: This study was carried out on twenty-six male rats. Five GI-n5, six GII, n6, and sixteen GIII, n15 of them were used as control, SHAM, and OBX groups, respectively, and followed eight weeks. PD-related clinical examinations were done before and after the experiment 1day, and animals were decapitated. The olfactory bulb volumes mm3, degenerated neuron densities of SSNSMG nmm3 and SMGl follicles volumes were detected serologically. Olfactory bulb volume values and degenerated neuron density values of SSNSMGnSMGl follicles volumes were compared statistically. Results: OBX-applied animals showed anosmia, tremors, rigidity, and memory loss. The mean olfactory bulb volumes mm3, degenerated neuron density of SSN nmm3, SMGn nmm3, and follicles volumes of SMGl cubic micrometermm3 were measured in the order written as; 4.270.21, 41, 52, 81.2313.34.106 in GI; 3.670.33, 143, 174, 72.4511.78.106 in GII and 2.910.14, 235, 298, 57.1911.93.106 in Group III. The mean P values between olfactory bulb volumes, degenerated neuron densities of SSN and SMGn, and salivary follicles volumes were: p0.005 in GIGII; p0.0005 in GIIGIII; p0.0001 in GIGIII. Conclusion: OBX-related olfactory network designalisation may be responsible for SSNSMGn circuitry degeneration-induced SMGl atrophy-based dry mouth. The OBX-related dry mouth should be considered a causative factor for Parkinsons disease, not a result.

 Aim: Dry mouth has been considered a clinical finding of Parkinsons disease PD, but we think otherwise. We studied if the olfactory bulbectomy OBX might rely on the superior salivatory nucleus SSN, submandibular ganglia SMGn, and submandibular glands SLGl circuity disruption induced submandibular gland degeneration related dry mouth in rats. Material and Method: This study was carried out on twenty-six male rats. Five GI-n5, six GII, n6, and sixteen GIII, n15 of them were used as control, SHAM, and OBX groups, respectively, and followed eight weeks. PD-related clinical examinations were done before and after the experiment 1day, and animals were decapitated. The olfactory bulb volumes mm3, degenerated neuron densities of SSNSMG nmm3 and SMGl follicles volumes were detected serologically. Olfactory bulb volume values and degenerated neuron density values of SSNSMGnSMGl follicles volumes were compared statistically. Results: OBX-applied animals showed anosmia, tremors, rigidity, and memory loss. The mean olfactory bulb volumes mm3, degenerated neuron density of SSN nmm3, SMGn nmm3, and follicles volumes of SMGl cubic micrometermm3 were measured in the order written as; 4.270.21, 41, 52, 81.2313.34.106 in GI; 3.670.33, 143, 174, 72.4511.78.106 in GII and 2.910.14, 235, 298, 57.1911.93.106 in Group III. The mean P values between olfactory bulb volumes, degenerated neuron densities of SSN and SMGn, and salivary follicles volumes were: p0.005 in GIGII; p0.0005 in GIIGIII; p0.0001 in GIGIII. Conclusion: OBX-related olfactory network designalisation may be responsible for SSNSMGn circuitry degeneration-induced SMGl atrophy-based dry mouth. The OBX-related dry mouth should be considered a causative factor for Parkinsons disease, not a result.

Article Details

New determinants for causal neural mechanism of dry mouth in Parkinson’s disease induced by destruction of superior salivatory nucleus, facial nerve, and submandibular gland circuitry: an experimental study

Authors:

Mete Zeynal

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Sağlık Kurumları Yönetimi

Journal:

Anatolian Current Medical Journal Vol.5 Issue 2, pp.153-159

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001286196

pISSN:

2718-0115

Olfactory bulbectomy

salivatory nucleus

submandibular ganglion

facial nerve

salivary gland

Olfactory bulbectomy

salivatory nucleus

submandibular ganglion

facial nerve

salivary gland

Issues

Article Details

Authors: Mete Zeynal

Publisher: MediHealth Academy Yayıncılık

Main Topics: Sağlık Kurumları Yönetimi

Journal: Anatolian Current Medical Journal Vol.5 Issue 2, pp.153-159

Document Type: Article

Publication Date: 3/2023

Document Language: English

Document ID (Org No.): 2001286196

pISSN: 2718-0115

Issues

Authors:

Mete Zeynal

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Sağlık Kurumları Yönetimi

Journal:

Anatolian Current Medical Journal Vol.5 Issue 2, pp.153-159

Document Type:

Article

Publication Date:

3/2023

Document Language:

English

Document ID (Org No.):

2001286196

pISSN:

2718-0115