The Effects of Intra-Articular Injections of Botulinum Toxin A on Experimentally Temporomandibular Joint Osteoarthritis Models

Mehmet YALTIRIK; Alen PALANCIOĞLU; Karolin YANAR; Cevat Tuğrul TURGUT; Bilge BİLGİÇ

Article Details

The Effects of Intra-Articular Injections of Botulinum Toxin A on Experimentally Temporomandibular Joint Osteoarthritis Models

Authors:

Mehmet YALTIRIK | Alen PALANCIOĞLU | Karolin YANAR | Cevat Tuğrul TURGUT | Bilge BİLGİÇ

Publisher:

Marmara University

Journal:

Clinical and Experimental Health Sciences 2018 Vol.8 Issue 1, pp.9-13

Document Type:

Article

Publication Date:

3/2018

Document Language:

English

Document ID (Org No.):

2000907183

Frequency:

Monthly

eISSN:

2459-1459

Abstract:

 


Objective: The aim of this study is to investigate the changes of temporomandibular

joint (TMJ) by experimentally induced osteoarthritis (OA) and

the effectiveness of botulinum toxin A (BTX-A) treatment via histopathological

and biochemical methods.

Methods: Sprague-Dawley rats, aged 8 to 10 weeks, were used in this

study. Intra-articular monosodium iodoacetate (MIA) solution was injected

bilaterally into two experimental groups to induce TMJ osteoarthritis.

Sterile 0.9% NaCl solution was injected to TMJ of healthy control group bilaterally

to investigate the effect of trauma by intra-articular injection. Development

of experimental osteoarthritis took 4 weeks, and blood samples

were harvested from MIA group and examined to prove the presence of

induced osteoarthritis. OA-induced eight rats with BTX-A. Another OA-induced

eight rats were classified as a control group and intra-articular 0.9%

NaCl solution was injected bilaterally. All samples were sacrificed 6 weeks

after treatment. Blood samples and specimen of TMJ were harvested from

all rats and examined histopathologically and biochemically.

Results: BTX-A and 0.9% NaCl solution groups showed some improvement

compared with untreated MIA group but it was not statistically significant.

There was no sign of trauma in 0.9% NaCl solution-injected healthy group.

Pathological findings were also consistent with the biochemical results.

Conclusion: BTX-A was not successful at treatment of OA and is not a proper

selection especially when used intra-articularly.

.

Article Details

The Effects of Intra-Articular Injections of Botulinum Toxin A on Experimentally Temporomandibular Joint Osteoarthritis Models

Authors: Mehmet YALTIRIK | Alen PALANCIOĞLU | Karolin YANAR | Cevat Tuğrul TURGUT | Bilge BİLGİÇ

Publisher: Marmara University

Journal: Clinical and Experimental Health Sciences 2018 Vol.8 Issue 1, pp.9-13

Document Type: Article

Publication Date: 3/2018

Document Language: English

Document ID (Org No.): 2000907183

Frequency: Monthly

eISSN: 2459-1459

Issues

Authors:

Mehmet YALTIRIK | Alen PALANCIOĞLU | Karolin YANAR | Cevat Tuğrul TURGUT | Bilge BİLGİÇ

Publisher:

Marmara University

Journal:

Clinical and Experimental Health Sciences 2018 Vol.8 Issue 1, pp.9-13

Document Type:

Article

Publication Date:

3/2018

Document Language:

English

Document ID (Org No.):

2000907183

Frequency:

Monthly

eISSN:

2459-1459