Long-term effects of pentoxifylline in heart failure therapy

Ahmet KARAGÖZ; Özgül UÇAR; Ayşe YÜKSEL; Sinan AYDOĞDU

Article Details

Long-term effects of pentoxifylline in heart failure therapy

Authors:

Ahmet KARAGÖZ | Özgül UÇAR | Ayşe YÜKSEL | Sinan AYDOĞDU

Publisher:

Ondokuz Mayıs University

Main Topics:

Promotion of health

Journal:

Journal of Experimental and Clinical Medicine 2014 Vol.31 Issue 1, pp.19-23

Document Type:

Article

Publication Date:

6/2014

Document Language:

English

Document ID (Org No.):

2000508630

Frequency:

Quarterly

eISSN:

1309-5129

pISSN:

1309-4483

Abstract:

 

The aim of the present study is to investigate the effects of pentoxifylline on left ventricular
ejection fractions (EF) and volumes, New York Heart Association (NYHA) functional
class, left ventricular diastolic parameters and hospitalization for heart failure in patients
with ischemic or non-ischemic cardiomyopathy. A total of 60 patients were randomised
to either peroral 1200 mg/day pentoxifylline or control group. All patients were on optimal
heart failure therapy and their EF was <40% by transthoracic echocardiography. The
patients were followed up for 12 months. Twenty-one patients (70%) in pentoxifylline
group and 20 (66.7%) in control group completed the study. Baseline and 12 months’
end-diastolic volume, end-systolic volume, EF and NYHA class were as follows in pentoxifylline
group; 160.5±51.3 mL vs 156.6±43.1 mL, 109.1±40 mL vs 106.1±33.4 mL,
32.4±5.7% vs 33.2±5.2%, 2.4±0.5 vs 2.2±0.5, p=0.5411, 0.5257, 0.4099 and 0.1037; respectively.
There were also no difference in baseline and follow-up diastolic parameters.
Mean hospitalization numbers for heart failure were similar between groups (1.26±0.71
vs 1.60±1.04, p=0.1717). Contrary to previous reports, no beneficial effect of pentoxifylline
was observed on clinical or echocardiographic parameters.

Article Details

Long-term effects of pentoxifylline in heart failure therapy

Authors: Ahmet KARAGÖZ | Özgül UÇAR | Ayşe YÜKSEL | Sinan AYDOĞDU

Publisher: Ondokuz Mayıs University

Main Topics: Promotion of health

Journal: Journal of Experimental and Clinical Medicine 2014 Vol.31 Issue 1, pp.19-23

Document Type: Article

Publication Date: 6/2014

Document Language: English

Document ID (Org No.): 2000508630

Frequency: Quarterly

eISSN: 1309-5129

pISSN: 1309-4483

Issues

Authors:

Ahmet KARAGÖZ | Özgül UÇAR | Ayşe YÜKSEL | Sinan AYDOĞDU

Publisher:

Ondokuz Mayıs University

Main Topics:

Promotion of health

Journal:

Journal of Experimental and Clinical Medicine 2014 Vol.31 Issue 1, pp.19-23

Document Type:

Article

Publication Date:

6/2014

Document Language:

English

Document ID (Org No.):

2000508630

Frequency:

Quarterly

eISSN:

1309-5129

pISSN:

1309-4483