Mortality in Critically  Ill Children Post Red Blood Cell Transfusion

AL Jboor , Wejdan Salem

doi:10.5742/MEJIM.2011.55150

Article Details

Mortality in Critically Ill Children Post Red Blood Cell Transfusion

Authors:

AL Jboor , Wejdan Salem

Publisher:

medi+WORLD International

Main Topics:

Medicine

Journal:

Middle East Journal of Internal Medicine 2012 vol.5 Issue 5, pp.19-24

Document Type:

Article

Publication Date:

9/2012

Document Language:

English

Document ID (Org No.):

17656

Frequency:

Quarterly

eISSN:

18379060

pISSN:

18379052

DOI:

10.5742/MEJIM.2011.55150

Descriptors:

Keywords:

Abstract:

 Objective: The aim of this study is to find if there is an association between RBC transfusion and mortality in critically ill children in the Pediatric Intensive Care Unit (PICU). Setting: At a single center, mixed medical and surgical, 18 beds Pediatric Intensive Care Unit (PICU) of Queen Rania Hospital for Children (QRHC). 
Patients and Methods: This study retrospectively analyzed the medical records of all patients who were admitted to PICU between August, 31, 2010 to September, 1, 2011 to identify the children who have Hb<13g/dl. Age groups between 3 days to 14 years were included in this study. Patients were put into two groups; the first group were children who received red blood cell (RBC) transfusion and were compared with the other patients in the second group who did not receive RBC transfusion. All surgical patients were included in this study except neurosurgical and cardio surgical patients whose operations were done outside QRHC. Any children known to have chronic anemia were excluded from this study. The hemoglobin value for each patient was recorded on admission within the first 6 hours of admission as base line. 
Results: Among 437 children in PICU over the period of the study 231 (52.8%) children were identified to have Hb <13g/dl, with age ranged between 3 days and 14 years (median age 5.6 years), who were included in this study. They were put into two groups according to RBC transfusion. Transfused patients (group 1) and non-transfused patients (group 2) were estimated at 132 (57.2%), 99 (42.8%) respectively. Mortality was estimated for both groups, (28.6%, versus 11.7 %) odds ratio 3.87, and 95% confidence interval: 2.34 to 5.16, p<0.001) for transfused patients and non-transfused patients respectively. Increased number of blood transfusions were associated with significant increase in mortality (p<0.001). 
Conclusion: RBC transfusion is significantly associated with increased mortality in critically ill children. Further research is needed to improve the outcome of RBC transfusion and to balance its benefit against the risks associated with it in critically ill children.

Article Details

Mortality in Critically Ill Children Post Red Blood Cell Transfusion

Authors:

AL Jboor , Wejdan Salem

Publisher:

medi+WORLD International

Main Topics:

Medicine

Journal:

Middle East Journal of Internal Medicine 2012 vol.5 Issue 5, pp.19-24

Document Type:

Article

Publication Date:

9/2012

Document Language:

English

Document ID (Org No.):

17656

Frequency:

Quarterly

eISSN:

18379060

pISSN:

18379052

DOI:

10.5742/MEJIM.2011.55150

Descriptors:

ERYTHROCYTES

ANAEMIA

CHILDREN DISEASES

CRITICAL CARE

THERAPY

BLOOD TRANSFUSION

MORTALITY

JORDAN

Mortality

RBC transfusion

critical

children

Issues

Article Details

Authors: AL Jboor , Wejdan Salem

Publisher: medi+WORLD International

Main Topics: Medicine

Journal: Middle East Journal of Internal Medicine 2012 vol.5 Issue 5, pp.19-24

Document Type: Article

Publication Date: 9/2012

Document Language: English

Document ID (Org No.): 17656

Frequency: Quarterly

eISSN: 18379060

pISSN: 18379052

DOI: 10.5742/MEJIM.2011.55150

Descriptors:

Issues

Authors:

AL Jboor , Wejdan Salem

Publisher:

medi+WORLD International

Main Topics:

Medicine

Journal:

Middle East Journal of Internal Medicine 2012 vol.5 Issue 5, pp.19-24

Document Type:

Article

Publication Date:

9/2012

Document Language:

English

Document ID (Org No.):

17656

Frequency:

Quarterly

eISSN:

18379060

pISSN:

18379052

DOI:

10.5742/MEJIM.2011.55150