Anthropometric Measurements in a Group of Congenital Adrenal Hyperplasia Egyptian Children and Related ECHO Changes

Nermine H. Amr; Omneya I. Youssef; Tareq M. Kamal; Sylvia S. Nasseif; Nadin N. Toaima

doi:10.12816/0054713

Article Details

Anthropometric Measurements in a Group of Congenital Adrenal Hyperplasia Egyptian Children and Related ECHO Changes

Authors:

Nermine H. Amr | Omneya I. Youssef | Tareq M. Kamal | Sylvia S. Nasseif | Nadin N. Toaima

Publisher:

Ain Shams University : Egyptian Paediatric Society

Main Topics:

Medicine

Journal:

Egyptian Journal of Pediatrics 2019 Vol.36 Issue 3-4, pp.433-445

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

137530

Frequency:

Quarterly

pISSN:

16871677

DOI:

10.12816/0054713

Descriptors:

Keywords:

Abstract:

 Background: Congenital Adrenal Hyperplasia (CAH) is one of the most common autosomal recessive endocrinal disorders caused by enzymatic deficiencies particularly 21 hydroxylase deficiency (21OHD) causing increased androgens and deficient cortisol and aldosterone.Objective: To evaluate the anthropometric data in a group of pediatric patients with CAH and subsequent ECHO changes.Subjects and Methods: This case-control study was conducted on 20 congenital adrenal hyperplasia patients (17 females and 3 males), aged 6.81 - 18.99 years (mean 13.75 years), on hydrocortisone for more than 6 years compared to 20 healthy age- and sex-matched controls. Patients were diagnosed on clinical, laboratory and genetic basis and are following-up regularly at the Pediatric Endocrinology Clinic, Children's Hospital, Ain-Shams University. Records of all patients were revised for data related to initial assessment and diagnosis. Complete history taking, physical examination; focusing on weight-SDS, height-SDS, BMI-SDS, free testosterone, 17 OH-progesterone, cortisol and ACTH and transthoracic Echocardiography for both cases and controls using M-mode, tissue Doppler and Myocardial Performance Index were done.Results: The Age of onset of hydrocortisone therapy ranged from 0.13 month to 103 months (median = 5 months). Seventeen patients (85%) were consanguineous and 11 of them (55%) had similar familyhistory. Salt-losing manifestations affected 80% of patients, and received daily steroid dose (mean = 15.88 ±3.99 mg/m2/day for 12.53 ±3.77 years. Median BMI SDS of patients was significantly higher than control group. ECHO data revealed left ventricular dilatation and hypertrophy resulting in cardiac systolic and diastolic dysfunction.Conclusion: Long standing exposure to glucocorticoids as a main treatment of CAH patients can affect BMI over time and later affects diastolic and systolic functions of the heart.

Article Details

Anthropometric Measurements in a Group of Congenital Adrenal Hyperplasia Egyptian Children and Related ECHO Changes

Authors:

Nermine H. Amr | Omneya I. Youssef | Tareq M. Kamal | Sylvia S. Nasseif | Nadin N. Toaima

Publisher:

Ain Shams University : Egyptian Paediatric Society

Main Topics:

Medicine

Journal:

Egyptian Journal of Pediatrics 2019 Vol.36 Issue 3-4, pp.433-445

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

137530

Frequency:

Quarterly

pISSN:

16871677

DOI:

10.12816/0054713

Descriptors:

ADRENAL GLANDS

HYPERPLASIA

BODY MEASUREMENTS

DIAGNOSIS

PAEDIATRICS

CHILDREN

EGYPT

CAH

Weight

Height

BMI

Corticosteroids

ECHO

Issues

Article Details

Authors: Nermine H. Amr | Omneya I. Youssef | Tareq M. Kamal | Sylvia S. Nasseif | Nadin N. Toaima

Publisher: Ain Shams University : Egyptian Paediatric Society

Main Topics: Medicine

Journal: Egyptian Journal of Pediatrics 2019 Vol.36 Issue 3-4, pp.433-445

Document Type: Article

Publication Date: 12/2019

Document Language: English

Document ID (Org No.): 137530

Frequency: Quarterly

pISSN: 16871677

DOI: 10.12816/0054713

Descriptors:

Issues

Authors:

Nermine H. Amr | Omneya I. Youssef | Tareq M. Kamal | Sylvia S. Nasseif | Nadin N. Toaima

Publisher:

Ain Shams University : Egyptian Paediatric Society

Main Topics:

Medicine

Journal:

Egyptian Journal of Pediatrics 2019 Vol.36 Issue 3-4, pp.433-445

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

137530

Frequency:

Quarterly

pISSN:

16871677

DOI:

10.12816/0054713