Acetylcholinesterase inhibitory activities and LC-MS  analysis of the antioxidant Ferula caspica M. Bieb. and          F. halophila Peşmen extracts

Çiğdem Kahraman; İffet İrem Tatlı Çankaya; Fatih Göğer; Neşe Kırımer

Article Details

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Authors:

Çiğdem Kahraman | İffet İrem Tatlı Çankaya | Fatih Göğer | Neşe Kırımer

Publisher:

Marmara University

Main Topics:

Pharmacognosy

Journal:

Journal of Research in Pharmacy Vol.23 Issue 3, pp.543-551

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347201

pISSN:

2630-6344

Keywords:

Abstract:

 The aim of the current study is to evaluate the biological activity of F. caspica M. Bieb. which is used for the treatment of diabetes in traditional Turkish medicine and to compare with F. halophila Peşmen. Antioxidant capacities and total phenolic contents of the plants extracts were tested by DPPH radical scavenging assay and Folin Ciocalteu assay, respectively. Acetylcholinesterase inhibitory activities of the extracts were investigated with the aim of indicating whether there was a correlation with their antioxidant capacities. Different quinic acid and flavonoid derivatives which may be responsible for the activities of the extracts were detected using LC-MS screening in the methanol extracts. The methanol extract from the aerial parts of F. caspica was found to show most antioxidant capacity and acetylcholinesterase inhibitory activity.

 The aim of the current study is to evaluate the biological activity of F. caspica M. Bieb. which is used for the treatment of diabetes in traditional Turkish medicine and to compare with F. halophila Peşmen. Antioxidant capacities and total phenolic contents of the plants extracts were tested by DPPH radical scavenging assay and Folin Ciocalteu assay, respectively. Acetylcholinesterase inhibitory activities of the extracts were investigated with the aim of indicating whether there was a correlation with their antioxidant capacities. Different quinic acid and flavonoid derivatives which may be responsible for the activities of the extracts were detected using LC-MS screening in the methanol extracts. The methanol extract from the aerial parts of F. caspica was found to show most antioxidant capacity and acetylcholinesterase inhibitory activity.

 The aim of the current study is to evaluate the biological activity of F. caspica M. Bieb. which is used for the treatment of diabetes in traditional Turkish medicine and to compare with F. halophila Peşmen. Antioxidant capacities and total phenolic contents of the plants extracts were tested by DPPH radical scavenging assay and Folin Ciocalteu assay, respectively. Acetylcholinesterase inhibitory activities of the extracts were investigated with the aim of indicating whether there was a correlation with their antioxidant capacities. Different quinic acid and flavonoid derivatives which may be responsible for the activities of the extracts were detected using LC-MS screening in the methanol extracts. The methanol extract from the aerial parts of F. caspica was found to show most antioxidant capacity and acetylcholinesterase inhibitory activity.

 The aim of the current study is to evaluate the biological activity of F. caspica M. Bieb. which is used for the treatment of diabetes in traditional Turkish medicine and to compare with F. halophila Peşmen. Antioxidant capacities and total phenolic contents of the plants extracts were tested by DPPH radical scavenging assay and Folin Ciocalteu assay, respectively. Acetylcholinesterase inhibitory activities of the extracts were investigated with the aim of indicating whether there was a correlation with their antioxidant capacities. Different quinic acid and flavonoid derivatives which may be responsible for the activities of the extracts were detected using LC-MS screening in the methanol extracts. The methanol extract from the aerial parts of F. caspica was found to show most antioxidant capacity and acetylcholinesterase inhibitory activity.

Article Details

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Authors:

Çiğdem Kahraman | İffet İrem Tatlı Çankaya | Fatih Göğer | Neşe Kırımer

Publisher:

Marmara University

Main Topics:

Pharmacognosy

Journal:

Journal of Research in Pharmacy Vol.23 Issue 3, pp.543-551

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347201

pISSN:

2630-6344

Ferula

antioxidant capacity

acetylcholinesterase inhibition

LC-MS

Issues

Article Details

Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Authors: Çiğdem Kahraman | İffet İrem Tatlı Çankaya | Fatih Göğer | Neşe Kırımer

Publisher: Marmara University

Main Topics: Pharmacognosy

Journal: Journal of Research in Pharmacy Vol.23 Issue 3, pp.543-551

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001347201

pISSN: 2630-6344

Ferula

antioxidant capacity

acetylcholinesterase inhibition

LC-MS

Issues

Authors:

Çiğdem Kahraman | İffet İrem Tatlı Çankaya | Fatih Göğer | Neşe Kırımer

Publisher:

Marmara University

Main Topics:

Pharmacognosy

Journal:

Journal of Research in Pharmacy Vol.23 Issue 3, pp.543-551

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001347201

pISSN:

2630-6344