Elevated neutrophil to lymphocyte ratio as an indicator of secondary erythema nodosum, a retrospective observational study

Yildiz HAYRAN; Ayşe ÖKTEM; Emine Buket ŞAHİN; Pinar İncel UYSAL; Nuran ALLI; Başak YALÇIN

Article Details

Elevated neutrophil to lymphocyte ratio as an indicator of secondary erythema nodosum, a retrospective observational study

Authors:

Yildiz HAYRAN | Ayşe ÖKTEM | Emine Buket ŞAHİN | Pinar İncel UYSAL | Nuran ALLI | Başak YALÇIN

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.624-634

Document Type:

Article

Publication Date:

3/2019

Document Language:

Turkish

Document ID (Org No.):

2000750219

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Abstract:

 

Background/aim:  Erythema  nodosum  (EN)  is  an  inflammatory  disorder  of  subcutaneous  tissue.  Although  etiopathogenesis  of  the  disease  is  unknown,  many  predisposing  factors  such  as  infections,  systemic  disease,  and  drugs  have  been  identified.  Neutrophil  to  lymphocyte ratio (NLR) has been shown to be a novel inflammatory marker in many dermatological diseases. The aim of our study is to investigate NLR in EN patients and evaluate its relation to the underlying cause of the disease.Materials and methods: Between 2014 and 2018, clinical and laboratory data of 395 patients diagnosed with EN and 395 controls were extracted from patient files. EN patients were grouped as idiopathic EN and secondary EN (EN with an identified underlying cause). Clinical and laboratory characteristics of the two groups were compared. Results: NLR was elevated in EN patients compared to controls (median of 2.38 vs. 1.55, P  2.11), RDW-CV (> 13.65), and CRP (> 5.5) were identified as risk factors for secondary EN (relative risks were 17.16, 2.69, and 2, respectively). Conclusion: Elevated NLR (> 2.11) may be used as a parameter to discriminate secondary EN from idiopathic EN.

Article Details

Elevated neutrophil to lymphocyte ratio as an indicator of secondary erythema nodosum, a retrospective observational study

Authors: Yildiz HAYRAN | Ayşe ÖKTEM | Emine Buket ŞAHİN | Pinar İncel UYSAL | Nuran ALLI | Başak YALÇIN

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.624-634

Document Type: Article

Publication Date: 3/2019

Document Language: Turkish

Document ID (Org No.): 2000750219

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

Issues

Authors:

Yildiz HAYRAN | Ayşe ÖKTEM | Emine Buket ŞAHİN | Pinar İncel UYSAL | Nuran ALLI | Başak YALÇIN

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.624-634

Document Type:

Article

Publication Date:

3/2019

Document Language:

Turkish

Document ID (Org No.):

2000750219

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144