Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety

Fatih Tok; Elif Kaya Tilki; Miriş Dikmen; Bedia Kaymakçıoğlu

Article Details

Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety

Authors:

Fatih Tok | Elif Kaya Tilki | Miriş Dikmen | Bedia Kaymakçıoğlu

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.26 Issue 1, pp.13-19

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346099

pISSN:

2630-6344

Keywords:

Abstract:

 In this study, some new carbohydrazide derivatives bearing furan moiety were synthesized. All carbohydrazide structures have been characterized by IR, 1H-NMR and elemental analysis. Anticancer activity of compounds were investigated on A549 human lung cancer and BJ normal fibroblast cells. According to the MTT assay results, all compounds demonstrated the cytotoxic activity on A549 cells with IC50 values of 43.38-342.63 µM except compound 3g. Only the IC50 values of compound 3c was below 400 µM on BJ cells. Especially, compound 3e showed significant anticancer effects on A549 cells with IC50 value of 43.38 µM and also didnt show cytotoxic effects on normal BJ cells.

 In this study, some new carbohydrazide derivatives bearing furan moiety were synthesized. All carbohydrazide structures have been characterized by IR, 1H-NMR and elemental analysis. Anticancer activity of compounds were investigated on A549 human lung cancer and BJ normal fibroblast cells. According to the MTT assay results, all compounds demonstrated the cytotoxic activity on A549 cells with IC50 values of 43.38-342.63 µM except compound 3g. Only the IC50 values of compound 3c was below 400 µM on BJ cells. Especially, compound 3e showed significant anticancer effects on A549 cells with IC50 value of 43.38 µM and also didnt show cytotoxic effects on normal BJ cells.

 In this study, some new carbohydrazide derivatives bearing furan moiety were synthesized. All carbohydrazide structures have been characterized by IR, 1H-NMR and elemental analysis. Anticancer activity of compounds were investigated on A549 human lung cancer and BJ normal fibroblast cells. According to the MTT assay results, all compounds demonstrated the cytotoxic activity on A549 cells with IC50 values of 43.38-342.63 µM except compound 3g. Only the IC50 values of compound 3c was below 400 µM on BJ cells. Especially, compound 3e showed significant anticancer effects on A549 cells with IC50 value of 43.38 µM and also didnt show cytotoxic effects on normal BJ cells.

 In this study, some new carbohydrazide derivatives bearing furan moiety were synthesized. All carbohydrazide structures have been characterized by IR, 1H-NMR and elemental analysis. Anticancer activity of compounds were investigated on A549 human lung cancer and BJ normal fibroblast cells. According to the MTT assay results, all compounds demonstrated the cytotoxic activity on A549 cells with IC50 values of 43.38-342.63 µM except compound 3g. Only the IC50 values of compound 3c was below 400 µM on BJ cells. Especially, compound 3e showed significant anticancer effects on A549 cells with IC50 value of 43.38 µM and also didnt show cytotoxic effects on normal BJ cells.

Article Details

Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety

Authors:

Fatih Tok | Elif Kaya Tilki | Miriş Dikmen | Bedia Kaymakçıoğlu

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.26 Issue 1, pp.13-19

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346099

pISSN:

2630-6344

Amide

furan

anticancer

carbohydrazide

Issues

Article Details

Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety

Authors: Fatih Tok | Elif Kaya Tilki | Miriş Dikmen | Bedia Kaymakçıoğlu

Publisher: Marmara University

Main Topics: Pharmacology and Pharmaceutical Sciences (Other)

Journal: Journal of Research in Pharmacy Vol.26 Issue 1, pp.13-19

Document Type: Article

Publication Date: 6/2025

Document Language: English

Document ID (Org No.): 2001346099

pISSN: 2630-6344

Amide

furan

anticancer

carbohydrazide

Issues

Authors:

Fatih Tok | Elif Kaya Tilki | Miriş Dikmen | Bedia Kaymakçıoğlu

Publisher:

Marmara University

Main Topics:

Pharmacology and Pharmaceutical Sciences (Other)

Journal:

Journal of Research in Pharmacy Vol.26 Issue 1, pp.13-19

Document Type:

Article

Publication Date:

6/2025

Document Language:

English

Document ID (Org No.):

2001346099

pISSN:

2630-6344