Assessing the Impact of Hypercapnic Stimulation on Brain Connectivity Metrics During Functional Magnetic Resonance Imaging

İdiz İset; Ali Bayram

Article Details

Assessing the Impact of Hypercapnic Stimulation on Brain Connectivity Metrics During Functional Magnetic Resonance Imaging

Authors:

İdiz İset | Ali Bayram

Publisher:

Istanbul University

Main Topics:

Clinical Sciences (Other)

Journal:

Experimed Vol.14 Issue 1, pp.54-60

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001318154

pISSN:

2667-5846

Keywords:

Abstract:

 Objective: Functional connectivity serves as a widely employed metric in neuroscience research focusing on the dynamics of the brain. Additionally, non-neuronal physiological oscillations are acknowledged as being able to impact functional connectivity. This study aimed to explore the effects of non-neuronal hypercapnic stimulation on the activity of intrinsic connectivity networks ICNs, as well as the dynamic changes in connectivity between them. Materials and Methods: The study involved 10 healthy participants, encompassed their functional magnetic resonance imaging fMRI scans with carbon dioxide-enriched air stimuli in a block paradigm, with group independent component analysis GICA being used for defining ICNs. Similarity analysis has been conducted between the connectivity changes in the network components and the end-tidal partial pressure of carbon dioxide PETCO2. Results: The study has identified 40 components representing 10 ICNs. Of these, 11 components representing seven ICNs were found to have significantly correlated time courses with PETCO2. Among the networks without correlated components, the dynamic functional connectivity metrics of the language network and the subcortical network have been found to be significantly modulated by PETCO2. Conclusion: The cerebrovascular reactivity to a hypercapnic stimulus is a factor that influences changes in the blood oxygenation level-dependent fMRI signal. This non-neuronal effect is detectable for ICN components derived by the GICA technique and must be considered when making inferences about network connectivity metrics.

 Objective: Functional connectivity serves as a widely employed metric in neuroscience research focusing on the dynamics of the brain. Additionally, non-neuronal physiological oscillations are acknowledged as being able to impact functional connectivity. This study aimed to explore the effects of non-neuronal hypercapnic stimulation on the activity of intrinsic connectivity networks ICNs, as well as the dynamic changes in connectivity between them. Materials and Methods: The study involved 10 healthy participants, encompassed their functional magnetic resonance imaging fMRI scans with carbon dioxide-enriched air stimuli in a block paradigm, with group independent component analysis GICA being used for defining ICNs. Similarity analysis has been conducted between the connectivity changes in the network components and the end-tidal partial pressure of carbon dioxide PETCO2. Results: The study has identified 40 components representing 10 ICNs. Of these, 11 components representing seven ICNs were found to have significantly correlated time courses with PETCO2. Among the networks without correlated components, the dynamic functional connectivity metrics of the language network and the subcortical network have been found to be significantly modulated by PETCO2. Conclusion: The cerebrovascular reactivity to a hypercapnic stimulus is a factor that influences changes in the blood oxygenation level-dependent fMRI signal. This non-neuronal effect is detectable for ICN components derived by the GICA technique and must be considered when making inferences about network connectivity metrics.

 Objective: Functional connectivity serves as a widely employed metric in neuroscience research focusing on the dynamics of the brain. Additionally, non-neuronal physiological oscillations are acknowledged as being able to impact functional connectivity. This study aimed to explore the effects of non-neuronal hypercapnic stimulation on the activity of intrinsic connectivity networks ICNs, as well as the dynamic changes in connectivity between them. Materials and Methods: The study involved 10 healthy participants, encompassed their functional magnetic resonance imaging fMRI scans with carbon dioxide-enriched air stimuli in a block paradigm, with group independent component analysis GICA being used for defining ICNs. Similarity analysis has been conducted between the connectivity changes in the network components and the end-tidal partial pressure of carbon dioxide PETCO2. Results: The study has identified 40 components representing 10 ICNs. Of these, 11 components representing seven ICNs were found to have significantly correlated time courses with PETCO2. Among the networks without correlated components, the dynamic functional connectivity metrics of the language network and the subcortical network have been found to be significantly modulated by PETCO2. Conclusion: The cerebrovascular reactivity to a hypercapnic stimulus is a factor that influences changes in the blood oxygenation level-dependent fMRI signal. This non-neuronal effect is detectable for ICN components derived by the GICA technique and must be considered when making inferences about network connectivity metrics.

 Objective: Functional connectivity serves as a widely employed metric in neuroscience research focusing on the dynamics of the brain. Additionally, non-neuronal physiological oscillations are acknowledged as being able to impact functional connectivity. This study aimed to explore the effects of non-neuronal hypercapnic stimulation on the activity of intrinsic connectivity networks ICNs, as well as the dynamic changes in connectivity between them. Materials and Methods: The study involved 10 healthy participants, encompassed their functional magnetic resonance imaging fMRI scans with carbon dioxide-enriched air stimuli in a block paradigm, with group independent component analysis GICA being used for defining ICNs. Similarity analysis has been conducted between the connectivity changes in the network components and the end-tidal partial pressure of carbon dioxide PETCO2. Results: The study has identified 40 components representing 10 ICNs. Of these, 11 components representing seven ICNs were found to have significantly correlated time courses with PETCO2. Among the networks without correlated components, the dynamic functional connectivity metrics of the language network and the subcortical network have been found to be significantly modulated by PETCO2. Conclusion: The cerebrovascular reactivity to a hypercapnic stimulus is a factor that influences changes in the blood oxygenation level-dependent fMRI signal. This non-neuronal effect is detectable for ICN components derived by the GICA technique and must be considered when making inferences about network connectivity metrics.

Article Details

Assessing the Impact of Hypercapnic Stimulation on Brain Connectivity Metrics During Functional Magnetic Resonance Imaging

Authors:

İdiz İset | Ali Bayram

Publisher:

Istanbul University

Main Topics:

Clinical Sciences (Other)

Journal:

Experimed Vol.14 Issue 1, pp.54-60

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001318154

pISSN:

2667-5846

Cerebrovascular reactivity

hypercapnic stimulation

functional magnetic resonance imaging

functional network connectivity

intrinsic connectivity networks

Issues

Article Details

Assessing the Impact of Hypercapnic Stimulation on Brain Connectivity Metrics During Functional Magnetic Resonance Imaging

Authors: İdiz İset | Ali Bayram

Publisher: Istanbul University

Main Topics: Clinical Sciences (Other)

Journal: Experimed Vol.14 Issue 1, pp.54-60

Document Type: Article

Publication Date: 4/2024

Document Language: English

Document ID (Org No.): 2001318154

pISSN: 2667-5846

Cerebrovascular reactivity

hypercapnic stimulation

functional magnetic resonance imaging

functional network connectivity

intrinsic connectivity networks

Issues

Authors:

İdiz İset | Ali Bayram

Publisher:

Istanbul University

Main Topics:

Clinical Sciences (Other)

Journal:

Experimed Vol.14 Issue 1, pp.54-60

Document Type:

Article

Publication Date:

4/2024

Document Language:

English

Document ID (Org No.):

2001318154

pISSN:

2667-5846