Prospective examination of Tp-e interval and Tp-e/QT ratio in breast cancer patients receiving radiation therapy

Necla Gürdal

Article Details

Prospective examination of Tp-e interval and Tp-e/QT ratio in breast cancer patients receiving radiation therapy

Authors:

Necla Gürdal

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Radyoterapi | Sağlık Kurumları Yönetimi

Journal:

Journal of Medicine and Palliative Care Vol.4 Issue 4, pp.362-367

Document Type:

Article

Publication Date:

8/2023

Document Language:

English

Document ID (Org No.):

2001297607

pISSN:

2717-7505

Keywords:

Abstract:

 Aims: The aim of this prospective study was to investigate ventricular repolarization using the Tp-e interval, Tp-eQT ratio, and Tp-eQTc ratio in breast cancer patients treated with adjuvant radiotherapyRT following systemic chemotherapy. Methods: The study was designed as a national, single-center prospective study. According to the treatment protocol, electrocardiograms ECGs were taken from all patients on their first and last days of RT. Tp-e intervals, Tp-eQT ratios, and Tp-eQTc ratios were calculated based on the ECG recordings. The heart doses due to radiation exposure were examined with mean heart dose, V5, V10,V20, and V30 values. Results: 51 postsurgical patients, who were all treated with AC followed by weekly paclitaxel and had an indication for adjuvant RT, were included in the study. The mean heart dose was observed as median 205 cGy, and the V30 value was 0.01. When ECG measurements were analyzed, statistically significant increases were observed in Tp-e interval p0.001, QT interval p0.007, Tp-eQT ratio p0.001, and Tp-eQTc ratio p0.001 at the end of RT. Additionally, positive correlations were observed between mean heart dose and post RT Tp-e r 0.770,p0.01 and Tp-eQTc ratio r  0.778,p0.01 Conclusion: When compared to before RT, statistically significant prolongation of Tp-e interval and QT interval and increases in Tp-eQT ratio and Tp-eQTc ratio were detected which are thought to be predictive for ventricular repolarization process and ventricular rhythm disorders. In addition, the mean heart dose was positively correlated with Tp-e interval and Tp-eQTc ratio.

 Aims: The aim of this prospective study was to investigate ventricular repolarization using the Tp-e interval, Tp-eQT ratio, and Tp-eQTc ratio in breast cancer patients treated with adjuvant radiotherapyRT following systemic chemotherapy. Methods: The study was designed as a national, single-center prospective study. According to the treatment protocol, electrocardiograms ECGs were taken from all patients on their first and last days of RT. Tp-e intervals, Tp-eQT ratios, and Tp-eQTc ratios were calculated based on the ECG recordings. The heart doses due to radiation exposure were examined with mean heart dose, V5, V10,V20, and V30 values. Results: 51 postsurgical patients, who were all treated with AC followed by weekly paclitaxel and had an indication for adjuvant RT, were included in the study. The mean heart dose was observed as median 205 cGy, and the V30 value was 0.01. When ECG measurements were analyzed, statistically significant increases were observed in Tp-e interval p0.001, QT interval p0.007, Tp-eQT ratio p0.001, and Tp-eQTc ratio p0.001 at the end of RT. Additionally, positive correlations were observed between mean heart dose and post RT Tp-e r 0.770,p0.01 and Tp-eQTc ratio r  0.778,p0.01 Conclusion: When compared to before RT, statistically significant prolongation of Tp-e interval and QT interval and increases in Tp-eQT ratio and Tp-eQTc ratio were detected which are thought to be predictive for ventricular repolarization process and ventricular rhythm disorders. In addition, the mean heart dose was positively correlated with Tp-e interval and Tp-eQTc ratio.

 Aims: The aim of this prospective study was to investigate ventricular repolarization using the Tp-e interval, Tp-eQT ratio, and Tp-eQTc ratio in breast cancer patients treated with adjuvant radiotherapyRT following systemic chemotherapy. Methods: The study was designed as a national, single-center prospective study. According to the treatment protocol, electrocardiograms ECGs were taken from all patients on their first and last days of RT. Tp-e intervals, Tp-eQT ratios, and Tp-eQTc ratios were calculated based on the ECG recordings. The heart doses due to radiation exposure were examined with mean heart dose, V5, V10,V20, and V30 values. Results: 51 postsurgical patients, who were all treated with AC followed by weekly paclitaxel and had an indication for adjuvant RT, were included in the study. The mean heart dose was observed as median 205 cGy, and the V30 value was 0.01. When ECG measurements were analyzed, statistically significant increases were observed in Tp-e interval p0.001, QT interval p0.007, Tp-eQT ratio p0.001, and Tp-eQTc ratio p0.001 at the end of RT. Additionally, positive correlations were observed between mean heart dose and post RT Tp-e r 0.770,p0.01 and Tp-eQTc ratio r  0.778,p0.01 Conclusion: When compared to before RT, statistically significant prolongation of Tp-e interval and QT interval and increases in Tp-eQT ratio and Tp-eQTc ratio were detected which are thought to be predictive for ventricular repolarization process and ventricular rhythm disorders. In addition, the mean heart dose was positively correlated with Tp-e interval and Tp-eQTc ratio.

 Amaç: Prospektif olarak dizayn edilen bu çalışmada amacımız sistemik kemoterapiyi takiben adjuvan radyoterapi RT ile tedavi edilen meme kanseri hastalarında Tp-e aralığı, Tp-eQT oranı ve Tp-eQTc oranını kullanarak ventriküler repolarizasyonu araştırmaktır. Metod: Çalışma ulusal, tek merkezli prospektif bir çalışma olarak tasarlandı. Tedavi protokolüne göre tüm hastalardan RTnin ilk ve son günlerinde elektrokardiyogramlar EKG çekildi. EKG kayıtlarından Tp-e aralıkları, Tp-eQT oranları ve Tp-eQTc oranları hesaplandı. Radyasyon maruziyetine bağlı kalp dozları kalp mean doz, V5, V10,V20 ve V30 değerleri ile incelendi. Bulgular: Postoperatif sistemik tedavi sonrası adjuvan RT endikasyonu olan 51 hasta çalışmaya dahil edildi. Ortalama kalp dozu ortanca 205 cGy olarak gözlendi ve V30 değeri 0,01 idi. EKG ölçümleri incelendiğinde RT öncesine göre Tp-e aralığı p0,001, QT aralığı p0,007, Tp-eQT oranı p0,001 ve Tp-eQTc oranında p0,001 istatistiksel olarak anlamlı artışlar gözlendi. Ek olarak, ortalama kalp dozu ile RT sonrası Tp-e r 0.770,p0.01 ve Tp-eQTc oranı r 0.778,p0.01 arasında pozitif korelasyonlar gözlendi. Sonuç: Ventriküler repolarizasyon süreci ve ventriküler ritim bozuklukları için prediktif olduğu düşünülen Tp-e intervali ve QT intervalinde RT öncesine göre istatistiksel olarak anlamlı uzama ve Tp-eQT oranı ve Tp-eQTc oranında artış saptandı. Ek olarak, ortalama kalp dozu ile Tp-e aralığı ve Tp-eQTc oranı arasında pozitif korelasyon gözlendi.

Article Details

Prospective examination of Tp-e interval and Tp-e/QT ratio in breast cancer patients receiving radiation therapy

Authors:

Necla Gürdal

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Radyoterapi | Sağlık Kurumları Yönetimi

Journal:

Journal of Medicine and Palliative Care Vol.4 Issue 4, pp.362-367

Document Type:

Article

Publication Date:

8/2023

Document Language:

English

Document ID (Org No.):

2001297607

pISSN:

2717-7505

Radiotherapy

cardiac toxicity

breast cancer

Tp-e interval

Tp-e/QT ratio

Tp-e/QTc ratioMeme Kanseri

Radyoterapi

Tp-e Aralığı

Kardiyak toksisite

Tp-e/QT Oranı

Issues

Article Details

Authors: Necla Gürdal

Publisher: MediHealth Academy Yayıncılık

Main Topics: Radyoterapi | Sağlık Kurumları Yönetimi

Journal: Journal of Medicine and Palliative Care Vol.4 Issue 4, pp.362-367

Document Type: Article

Publication Date: 8/2023

Document Language: English

Document ID (Org No.): 2001297607

pISSN: 2717-7505

Issues

Authors:

Necla Gürdal

Publisher:

MediHealth Academy Yayıncılık

Main Topics:

Radyoterapi | Sağlık Kurumları Yönetimi

Journal:

Journal of Medicine and Palliative Care Vol.4 Issue 4, pp.362-367

Document Type:

Article

Publication Date:

8/2023

Document Language:

English

Document ID (Org No.):

2001297607

pISSN:

2717-7505