Compatibility Studies of Sildenafil with Different Excipients by Using TGA, DSC, XRD and FTIR

Hale SEÇİLMİŞ CANBAY; Mahmut DOĞANTÜRK

doi:https://doi.org/10.18466/cbayarfbe.613951

Article Details

Compatibility Studies of Sildenafil with Different Excipients by Using TGA, DSC, XRD and FTIR

Authors:

Hale SEÇİLMİŞ CANBAY | Mahmut DOĞANTÜRK

Publisher:

Celal Bayar University

Main Topics:

Applied physics

Journal:

Celal Bayar University Journal of Science 2019 Vol.15 Issue 4, pp.401-407

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

2000706003

Frequency:

Quarterly

eISSN:

1305-1385

pISSN:

1305-130X

DOI:

https://doi.org/10.18466/cbayarfbe.613951

Abstract:

 


Study of drug–excipient
interactions is a crucial step in preformulation stage of drug development to
achieve consistent chemical, physical, bioavailability, manufacturability and
stability of the dosage form.  In pre-formulation
studies, it is important to use thermoanalytical and spectroscopic methods.
These are important systems for achieving a suitable formulation. Sildenafil is a well-tolerated and highly
effective treatment for erectile dysfunction. erectile dysfunction was
revolutionized with the development of a
selective inhibitor of cyclic guanosine monophosphate-specific
phosphodiesterase type 5.  , Fourier Transform Infrared Spectroscopy, and X-ray Powder Diffraction systems were used in the investigation and to
determine the possible interactions between sildenafil and some excipients like
butylated hydroxyanisole, cellulose, sodium carboxymethyl cellulose, ascorbic acid, and citric acid. Binary mixtures of drug:excipient=1:1
(mass/mass) have been analyzed. According to the results, there is
incompatibility with butylated hydroxyanisole, ascorbic
acid, and citric acid.  

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Article Details

Compatibility Studies of Sildenafil with Different Excipients by Using TGA, DSC, XRD and FTIR

Authors: Hale SEÇİLMİŞ CANBAY | Mahmut DOĞANTÜRK

Publisher: Celal Bayar University

Main Topics: Applied physics

Journal: Celal Bayar University Journal of Science 2019 Vol.15 Issue 4, pp.401-407

Document Type: Article

Publication Date: 12/2019

Document Language: English

Document ID (Org No.): 2000706003

Frequency: Quarterly

eISSN: 1305-1385

pISSN: 1305-130X

DOI: https://doi.org/10.18466/cbayarfbe.613951

Issues

Authors:

Hale SEÇİLMİŞ CANBAY | Mahmut DOĞANTÜRK

Publisher:

Celal Bayar University

Main Topics:

Applied physics

Journal:

Celal Bayar University Journal of Science 2019 Vol.15 Issue 4, pp.401-407

Document Type:

Article

Publication Date:

12/2019

Document Language:

English

Document ID (Org No.):

2000706003

Frequency:

Quarterly

eISSN:

1305-1385

pISSN:

1305-130X

DOI:

https://doi.org/10.18466/cbayarfbe.613951