Role of melatonin on calcium signaling and mitochondrial oxidativestress in epilepsy: focus on TRP channels

Mustafa NAZIROĞLU

Article Details

Role of melatonin on calcium signaling and mitochondrial oxidativestress in epilepsy: focus on TRP channels

Authors:

Mustafa NAZIROĞLU

Publisher:

TUBITAK

Journal:

Turkish Journal of Biology 2015 Vol.39 Issue 6, pp.813-821

Document Type:

Article

Publication Date:

12/2015

Document Language:

Turkish

Document ID (Org No.):

2000811798

Frequency:

Bimonthly

eISSN:

1303-6092

pISSN:

1300-0152

Keywords:

Abstract:

 

Calcium ion (Ca2+) accumulation and excessive oxidative stress in the hippocampus and brain cortex have long been known as major contributors to the etiology of epilepsy. I have reviewed the role of Ca2+ signaling through cation channels and mitochondria-mediated oxidative stress on epilepsy in human and animals. A review of the relevant papers and results from recent studies were obtained from PubMed and the Science Citation Index. Current literature findings indicate that melatonin and agomelatine reduce activation of hippocampal transient receptor potential (TRP), glutamate receptors, and voltage-gated calcium channels that are critical for the development of abnormal Ca2+ homeostasis and oxidative stress and associated mitochondrial dysfunction. In addition, low doses of melatonin induce anticonvulsant action through increase of GABA levels in the hippocampus and brain cortex. The accumulating evidence implicates a modulator role of melatonin on excessive oxidative stress products, plus mitochondrial and Ca2+ dysregulations in epilepsy. The evidence indicates that modulation of oxidative stress and neuronal Ca2+ handling occurs through effects on TRP channels, suggesting an increasingly viable approach for therapeutic interventions against epilepsy.

 

Calcium ion (Ca2+) accumulation and excessive oxidative stress in the hippocampus and brain cortex have long been known as major contributors to the etiology of epilepsy. I have reviewed the role of Ca2+ signaling through cation channels and mitochondria-mediated oxidative stress on epilepsy in human and animals. A review of the relevant papers and results from recent studies were obtained from PubMed and the Science Citation Index. Current literature findings indicate that melatonin and agomelatine reduce activation of hippocampal transient receptor potential (TRP), glutamate receptors, and voltage-gated calcium channels that are critical for the development of abnormal Ca2+ homeostasis and oxidative stress and associated mitochondrial dysfunction. In addition, low doses of melatonin induce anticonvulsant action through increase of GABA levels in the hippocampus and brain cortex. The accumulating evidence implicates a modulator role of melatonin on excessive oxidative stress products, plus mitochondrial and Ca2+ dysregulations in epilepsy. The evidence indicates that modulation of oxidative stress and neuronal Ca2+ handling occurs through effects on TRP channels, suggesting an increasingly viable approach for therapeutic interventions against epilepsy.

Article Details

Role of melatonin on calcium signaling and mitochondrial oxidativestress in epilepsy: focus on TRP channels

Authors:

Mustafa NAZIROĞLU

Publisher:

TUBITAK

Journal:

Turkish Journal of Biology 2015 Vol.39 Issue 6, pp.813-821

Document Type:

Article

Publication Date:

12/2015

Document Language:

Turkish

Document ID (Org No.):

2000811798

Frequency:

Bimonthly

eISSN:

1303-6092

pISSN:

1300-0152

Calcium ion

epilepsy

oxidative stress

melatonin

transient receptor potential channels

mitochondria

Issues

Article Details

Role of melatonin on calcium signaling and mitochondrial oxidativestress in epilepsy: focus on TRP channels

Authors: Mustafa NAZIROĞLU

Publisher: TUBITAK

Journal: Turkish Journal of Biology 2015 Vol.39 Issue 6, pp.813-821

Document Type: Article

Publication Date: 12/2015

Document Language: Turkish

Document ID (Org No.): 2000811798

Frequency: Bimonthly

eISSN: 1303-6092

pISSN: 1300-0152

Calcium ion

epilepsy

oxidative stress

melatonin

transient receptor potential channels

mitochondria

Issues

Authors:

Mustafa NAZIROĞLU

Publisher:

TUBITAK

Journal:

Turkish Journal of Biology 2015 Vol.39 Issue 6, pp.813-821

Document Type:

Article

Publication Date:

12/2015

Document Language:

Turkish

Document ID (Org No.):

2000811798

Frequency:

Bimonthly

eISSN:

1303-6092

pISSN:

1300-0152