Down Sendromlu bir yenidoğanda geçici myeloproliferatif hastalık

Fatih DEMİRCİOĞLU; Hüseyin ALTUNHAN; Mervan BEKDAŞ; Sevil Bilir GÖKSÜGÜR; Erkan YEŞİLLER; Esma Gökçen SARAÇ; Erol KISMET

Article Details

Down Sendromlu bir yenidoğanda geçici myeloproliferatif hastalık

Authors:

Fatih DEMİRCİOĞLU | Hüseyin ALTUNHAN | Mervan BEKDAŞ | Sevil Bilir GÖKSÜGÜR | Erkan YEŞİLLER | Esma Gökçen SARAÇ | Erol KISMET

Publisher:

Bolu Abant Izzet Baysal University

Journal:

Abant Medical Journal 2013 Vol.2 Issue 1, pp.46-49

Document Type:

Article

Publication Date:

12/2012

Document Language:

Turkish

Document ID (Org No.):

2000436796

Frequency:

Tri-annual

eISSN:

2147-1800

pISSN:

1305-4392

Abstract:

 

Transient myeloproliferative disease  TMD , defined by circulating nonlymphoid blast in the peripheral blood, occurs in approximately 10% of infants with constitutional trisomy 21  Down syndrome . The TMD phenotype may also occur in newborns who do not have clinical signs of Down syndrome but nonconstitutional trisomy 21 due to mosaicism. Acute mega-karyoblastic leukemia  AML-M7  develops in approxima¬tely 30 % of the cases with TMD within the first three years of life. In this case report, a newborn with TMD with Down syndrome is presented. We emphasize the importance of the peripheral blood smear examination in newborns with DS, especially with hepatosplenomegaly, leukocytosis or throm¬bocytopenia and myeloblast of the peripheral smear, in order to diagnose TMD.

 

Geçici myeloproliferatif hastalık  GMPH , Trizomi 21  Down Sendromu  tanısı ile izlenen infantların yaklaşık %10’unda ortaya çıkabilen, periferik kanda myeloid blastların artımı ile karakterize bir durumdur. GMPH, Down Sendromun’nun işaretlerini taşımayan mozaik trizomi 21 hastalarında da görülebilir. GMPH’lı infantlarda ilk 3 yılda akut mega¬karyoblastik lösemi  AML-M7  gelişme riski yaklaşık % 30’dur. Biz burada GMPH gelişen Down Sendromlu bir vaka sunduk. Down sendromlu yenidoğanlarda hepasopslenomegali, lökositoz veya trombositopeni ve periferik kan yayma incelemeside myeloblast saptanması durumunda GMPH düşünülmesinin önemine vurgu yapmak istedik.

Article Details

Down Sendromlu bir yenidoğanda geçici myeloproliferatif hastalık

Authors: Fatih DEMİRCİOĞLU | Hüseyin ALTUNHAN | Mervan BEKDAŞ | Sevil Bilir GÖKSÜGÜR | Erkan YEŞİLLER | Esma Gökçen SARAÇ | Erol KISMET

Publisher: Bolu Abant Izzet Baysal University

Journal: Abant Medical Journal 2013 Vol.2 Issue 1, pp.46-49

Document Type: Article

Publication Date: 12/2012

Document Language: Turkish

Document ID (Org No.): 2000436796

Frequency: Tri-annual

eISSN: 2147-1800

pISSN: 1305-4392

Issues

Authors:

Fatih DEMİRCİOĞLU | Hüseyin ALTUNHAN | Mervan BEKDAŞ | Sevil Bilir GÖKSÜGÜR | Erkan YEŞİLLER | Esma Gökçen SARAÇ | Erol KISMET

Publisher:

Bolu Abant Izzet Baysal University

Journal:

Abant Medical Journal 2013 Vol.2 Issue 1, pp.46-49

Document Type:

Article

Publication Date:

12/2012

Document Language:

Turkish

Document ID (Org No.):

2000436796

Frequency:

Tri-annual

eISSN:

2147-1800

pISSN:

1305-4392