Radioprotective effect of Umbelliferon Against Radiation-Induced Myocardial Damages

Nurdan Dumlu; Fatime Geyikoğlu; Suat Çolak

Article Details

Radioprotective effect of Umbelliferon Against Radiation-Induced Myocardial Damages

Authors:

Nurdan Dumlu | Fatime Geyikoğlu | Suat Çolak

Publisher:

Erzincan Binali Yildirim University

Main Topics:

Eczacılık Biyokimyası

Journal:

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.17 Issue 3, pp.811-825

Document Type:

Article

Publication Date:

12/2024

Document Language:

English

Document ID (Org No.):

2001335772

pISSN:

2149-4584

Keywords:

Abstract:

 Radiation at a high dose may attenuate myocardial functions while presenting the therapeutic effect on cancer cells and thus can be life-threatening. Today, many studies reveal that supportive treatments provide important protective effects against acute radiation damage in vital organs including the heart. To our knowledge, the role of umbelliferone in the prevention of radiation damage to the heart has not yet been clarified. Therefore, the current study was planned to evaluate the role of umbelliferone radiation-induced cardiac injury using biochemical and histological data. Rats will be divided into eight different groups as control, radiation and treatment groups. No application was made to the control group. The second group animals were exposed to a single dose 12Gy radiation throughout the body. Groups 3, 4 and 5 were orally given umbelliferone 25, 50 and 100 mgkg single dose for 3 days. Groups 6, 7 and 8 received umbelliferone and then radiation was applied. After the experiments, the myocardial tissues of the rats were removed and the protection of the substance against radiation was investigated. Radiation exposure to the rats induced oxidative stress, inflammation, pathological changes and vascular dysfunction in cardiac tissue. Whereas umbelliferone in high dose 100 mgkg pretreatment supported the anti-oxidant activity and also reduced the inflammatory response on heart tissue against radiation-associated toxicity. Besides, radiation-induced histopathological changes significantly ameliorated in umbelliferone-treated rat groups. Umbelliferone 100 mgkg pretreatment reduced radiation-induced heart damage, which was thought to provide the greatest opportunity for umbelliferones efficacy as a new drug against the side effects of radiotherapy.

 Radiation at a high dose may attenuate myocardial functions while presenting the therapeutic effect on cancer cells and thus can be life-threatening. Today, many studies reveal that supportive treatments provide important protective effects against acute radiation damage in vital organs including the heart. To our knowledge, the role of umbelliferone in the prevention of radiation damage to the heart has not yet been clarified. Therefore, the current study was planned to evaluate the role of umbelliferone radiation-induced cardiac injury using biochemical and histological data. Rats will be divided into eight different groups as control, radiation and treatment groups. No application was made to the control group. The second group animals were exposed to a single dose 12Gy radiation throughout the body. Groups 3, 4 and 5 were orally given umbelliferone 25, 50 and 100 mgkg single dose for 3 days. Groups 6, 7 and 8 received umbelliferone and then radiation was applied. After the experiments, the myocardial tissues of the rats were removed and the protection of the substance against radiation was investigated. Radiation exposure to the rats induced oxidative stress, inflammation, pathological changes and vascular dysfunction in cardiac tissue. Whereas umbelliferone in high dose 100 mgkg pretreatment supported the anti-oxidant activity and also reduced the inflammatory response on heart tissue against radiation-associated toxicity. Besides, radiation-induced histopathological changes significantly ameliorated in umbelliferone-treated rat groups. Umbelliferone 100 mgkg pretreatment reduced radiation-induced heart damage, which was thought to provide the greatest opportunity for umbelliferones efficacy as a new drug against the side effects of radiotherapy.

 Radiation at a high dose may attenuate myocardial functions while presenting the therapeutic effect on cancer cells and thus can be life-threatening. Today, many studies reveal that supportive treatments provide important protective effects against acute radiation damage in vital organs including the heart. To our knowledge, the role of umbelliferone in the prevention of radiation damage to the heart has not yet been clarified. Therefore, the current study was planned to evaluate the role of umbelliferone radiation-induced cardiac injury using biochemical and histological data. Rats will be divided into eight different groups as control, radiation and treatment groups. No application was made to the control group. The second group animals were exposed to a single dose 12Gy radiation throughout the body. Groups 3, 4 and 5 were orally given umbelliferone 25, 50 and 100 mgkg single dose for 3 days. Groups 6, 7 and 8 received umbelliferone and then radiation was applied. After the experiments, the myocardial tissues of the rats were removed and the protection of the substance against radiation was investigated. Radiation exposure to the rats induced oxidative stress, inflammation, pathological changes and vascular dysfunction in cardiac tissue. Whereas umbelliferone in high dose 100 mgkg pretreatment supported the anti-oxidant activity and also reduced the inflammatory response on heart tissue against radiation-associated toxicity. Besides, radiation-induced histopathological changes significantly ameliorated in umbelliferone-treated rat groups. Umbelliferone 100 mgkg pretreatment reduced radiation-induced heart damage, which was thought to provide the greatest opportunity for umbelliferones efficacy as a new drug against the side effects of radiotherapy.

 Radiation at a high dose may attenuate myocardial functions while presenting the therapeutic effect on cancer cells and thus can be life-threatening. Today, many studies reveal that supportive treatments provide important protective effects against acute radiation damage in vital organs including the heart. To our knowledge, the role of umbelliferone in the prevention of radiation damage to the heart has not yet been clarified. Therefore, the current study was planned to evaluate the role of umbelliferone radiation-induced cardiac injury using biochemical and histological data. Rats will be divided into eight different groups as control, radiation and treatment groups. No application was made to the control group. The second group animals were exposed to a single dose 12Gy radiation throughout the body. Groups 3, 4 and 5 were orally given umbelliferone 25, 50 and 100 mgkg single dose for 3 days. Groups 6, 7 and 8 received umbelliferone and then radiation was applied. After the experiments, the myocardial tissues of the rats were removed and the protection of the substance against radiation was investigated. Radiation exposure to the rats induced oxidative stress, inflammation, pathological changes and vascular dysfunction in cardiac tissue. Whereas umbelliferone in high dose 100 mgkg pretreatment supported the anti-oxidant activity and also reduced the inflammatory response on heart tissue against radiation-associated toxicity. Besides, radiation-induced histopathological changes significantly ameliorated in umbelliferone-treated rat groups. Umbelliferone 100 mgkg pretreatment reduced radiation-induced heart damage, which was thought to provide the greatest opportunity for umbelliferones efficacy as a new drug against the side effects of radiotherapy.

Article Details

Radioprotective effect of Umbelliferon Against Radiation-Induced Myocardial Damages

Authors:

Nurdan Dumlu | Fatime Geyikoğlu | Suat Çolak

Publisher:

Erzincan Binali Yildirim University

Main Topics:

Eczacılık Biyokimyası

Journal:

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.17 Issue 3, pp.811-825

Document Type:

Article

Publication Date:

12/2024

Document Language:

English

Document ID (Org No.):

2001335772

pISSN:

2149-4584

Keywords: Radiation

umbelliferone

oxidative stress/antioxidant

cardio-toxicity

rat

Issues

Article Details

Radioprotective effect of Umbelliferon Against Radiation-Induced Myocardial Damages

Authors: Nurdan Dumlu | Fatime Geyikoğlu | Suat Çolak

Publisher: Erzincan Binali Yildirim University

Main Topics: Eczacılık Biyokimyası

Journal: Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.17 Issue 3, pp.811-825

Document Type: Article

Publication Date: 12/2024

Document Language: English

Document ID (Org No.): 2001335772

pISSN: 2149-4584

Keywords: Radiation

umbelliferone

oxidative stress/antioxidant

cardio-toxicity

rat

Issues

Authors:

Nurdan Dumlu | Fatime Geyikoğlu | Suat Çolak

Publisher:

Erzincan Binali Yildirim University

Main Topics:

Eczacılık Biyokimyası

Journal:

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.17 Issue 3, pp.811-825

Document Type:

Article

Publication Date:

12/2024

Document Language:

English

Document ID (Org No.):

2001335772

pISSN:

2149-4584