The association between urinary placental protein 13 and soluble fms-like tyrosine kinase-1 in preeclamptic women in the third trimester of pregnancy

Nesreen Nasser; Rayah Baban; May Al-Habib; Risala Jameel

doi:10.47419/bjbabs.v1i01.31

Article Details

The association between urinary placental protein 13 and soluble fms-like tyrosine kinase-1 in preeclamptic women in the third trimester of pregnancy

Authors:

Nesreen Nasser | Rayah Baban | May Al-Habib | Risala Jameel

Publisher:

College of Medicine, Al-Nahrain University

Main Topics:

Clinical biochemistry | galectin 13 | placental protein 13 | PP13 | preeclampsia | soluble fms-like tyrosine kinase-1

Journal:

Baghdad Journal of Biochemistry and Applied Biological Sciences Vol.1 Issue 1, pp.49-55

Document Type:

Article

Publication Date:

12/2020

Document Language:

English

Document ID (Org No.):

2001363853

pISSN:

2706-9915

DOI:

10.47419/bjbabs.v1i01.31

Keywords:

Abstract:

 Background: Preeclampsia (PE) is diagnosed after 20 weeks of gestation. This multisystem disorder affects 2-7% of pregnant women. PE is a serious complication of pregnancy and one of the main causes of maternal and neonatal mortality and morbidity in the world. The inadequate placentation process results in a change in anti-angiogenic factors levels, such as placental protein 13 (PP13) and soluble fms-like tyrosine kinase 1 (sFlt-1).
Objectives: To investigate the correlation between urinary PP13 and sFlt-1 in preeclamptic women in their third trimester of pregnancy.
Methods: A case-control study was carried out from August 2018 till January 2019. Urine samples were collected from pregnant women at Al-Elweyia Hospital, Al-Hakeem Hospital, and Al- Imamain Al-Kadhimain Medical City (in Baghdad, Iraq). The patients’ group include fifty women with PE in the third trimester (25 mild and 25 severe). Fifty healthy pregnant women (at their third trimester of pregnancy) were studied as a control group.
Results: The mean urinary PP13 levels were decreased in women with PE significantly (p≤ 0.05) (mild and severe) compared with healthy women (43.44±4.914 pg/ml, 33.34±1.863 pg/ml, and 51.84 ±2.60 pg/ml) respectively. Also, urinary sFlt-1 concentrations were decreased non-significantly (p> 0.05) in women with PE (mild and severe) compared with healthy women (5.71±0.414 ng/ml, 5.31±0.38 ng/ml and 6.01±0.282 ng/ml), respectively.
Conclusions: Urinary PP13 and sFlt-1 levels in the third trimester of pregnancy were significantly correlated with the severity of PE, and urinary levels of PP13 were found to be decreased significantly in patients with PE than in healthy pregnant women in the 3rd trimester of pregnancy.

Article Details

The association between urinary placental protein 13 and soluble fms-like tyrosine kinase-1 in preeclamptic women in the third trimester of pregnancy

Authors: Nesreen Nasser | Rayah Baban | May Al-Habib | Risala Jameel

Publisher: College of Medicine, Al-Nahrain University

Main Topics: Clinical biochemistry | galectin 13 | placental protein 13 | PP13 | preeclampsia | soluble fms-like tyrosine kinase-1

Journal: Baghdad Journal of Biochemistry and Applied Biological Sciences Vol.1 Issue 1, pp.49-55

Document Type: Article

Publication Date: 12/2020

Document Language: English

Document ID (Org No.): 2001363853

pISSN: 2706-9915

DOI: 10.47419/bjbabs.v1i01.31

Clinical biochemistry

galectin 13

placental protein 13

PP13

preeclampsia

soluble fms-like tyrosine kinase-1

Issues

Authors:

Nesreen Nasser | Rayah Baban | May Al-Habib | Risala Jameel

Publisher:

College of Medicine, Al-Nahrain University

Main Topics:

Clinical biochemistry | galectin 13 | placental protein 13 | PP13 | preeclampsia | soluble fms-like tyrosine kinase-1

Journal:

Baghdad Journal of Biochemistry and Applied Biological Sciences Vol.1 Issue 1, pp.49-55

Document Type:

Article

Publication Date:

12/2020

Document Language:

English

Document ID (Org No.):

2001363853

pISSN:

2706-9915

DOI:

10.47419/bjbabs.v1i01.31