Extrapyramidal Syndromes such as Oromandibular Dystonia, Akathisia, Parkinsonism as a Consequence of Paroxetine Use: A Case Report

Asli EGELİ; Mehmet Hamdi ORUM; Behice HAN-ALMİS

Article Details

Extrapyramidal Syndromes such as Oromandibular Dystonia, Akathisia, Parkinsonism as a Consequence of Paroxetine Use: A Case Report

Authors:

Asli EGELİ | Mehmet Hamdi ORUM | Behice HAN-ALMİS

Publisher:

Zülal ÖNER

Main Topics:

Diseases

Journal:

Medical Records 2019 Vol.1 Issue 2, pp.57-59

Document Type:

Article

Publication Date:

11/2019

Document Language:

English

Document ID (Org No.):

2000544411

Frequency:

Tri-annual

eISSN:

2687-4555

Abstract:

 


Selective serotonin
reuptake inhibitors (SSRI) are frequently used in the treatment of many
psychiatric disorders such as major depressive disorder, anxiety disorder, and
eating disorders. Side effects such as increased appetite, constipation, dry
mouth, sedation, restlessness, sweating and sexual dysfunction due to SSRI use
are frequently reported, while extrapyramidal syndromes (EPS) such as
akathisia, dystonia and parkinsonism are rarely seen. There are reports of
SSRIs such as fluoxetine, sertraline and fluvoxamine-induced EPS. We hereby
report a 37-year-old male case of EPS such as oromandibular dystonia,
akathisia, parkinsonism that developed after a chronic use of paroxetine 30
mg/day and its improvement with dose reduction. In this patient, paroxetine was
discontinued as dose-reduced paroxetine was not sufficient to treat anxiety
symptoms, and the use of escitalopram significantly reduced psychiatric
symptoms.


.

 


Selektif serotonin geri
alım inhibitörleri (SSGİ) major depresif bozukluk, anksiyete bozukluğu, yeme
bozuklukları gibi birçok psikiyatrik hastalığın tedavisinde sıklıkla kullanılmaktadır.
SSRI kullanımına bağlı iştah artışı, kabızlık, ağız kuruluğu, sedasyon,
huzursuzluk, terleme, cinsel işlev bozukluğu gibi yan etkiler sıklıkla
bildirilirken akatizi, distoni, parkinsonizm gibi extapiramidal sendromlar (EPS)
nadiren görülmektedir. Fluoksetin, sertralin ve fluvoksamin gibi SSGİ’lere
bağlı EPS bildirimleri bulunmaktadır. Burada, uzun süredir paroksetin 30 mg/gün
kullanan 37 yaşındaki erkek hastada ortaya çıkan oromandibular distoni,
akatizi, parkinsonism gibi EPS yan etkilerinin doz azaltımı ile iyileşmesini
sunduk. Bu hastada dozu azaltılmış paroksetin anksiyete semptomlarını tedavi
etmeye yeterli olmadığı için paroksetin kesildi ve essitalopram kullanımı ile psikiyatrik
semptomlar belirgin olarak azaltıldı.


.

Article Details

Extrapyramidal Syndromes such as Oromandibular Dystonia, Akathisia, Parkinsonism as a Consequence of Paroxetine Use: A Case Report

Authors: Asli EGELİ | Mehmet Hamdi ORUM | Behice HAN-ALMİS

Publisher: Zülal ÖNER

Main Topics: Diseases

Journal: Medical Records 2019 Vol.1 Issue 2, pp.57-59

Document Type: Article

Publication Date: 11/2019

Document Language: English

Document ID (Org No.): 2000544411

Frequency: Tri-annual

eISSN: 2687-4555

Issues

Authors:

Asli EGELİ | Mehmet Hamdi ORUM | Behice HAN-ALMİS

Publisher:

Zülal ÖNER

Main Topics:

Diseases

Journal:

Medical Records 2019 Vol.1 Issue 2, pp.57-59

Document Type:

Article

Publication Date:

11/2019

Document Language:

English

Document ID (Org No.):

2000544411

Frequency:

Tri-annual

eISSN:

2687-4555