The Compound Specific Antibacterial Activities of Major Urolithins and Their Methyl Ethers

Hayrettin Ozan GÜLCAN; Mehmet İLKTAÇ; Bahareh NOSHADİ; Karar SHUKUR; Mustafa GAZİ

doi:https://doi.org/10.18596/jotcsa.861808

Article Details

The Compound Specific Antibacterial Activities of Major Urolithins and Their Methyl Ethers

Authors:

Hayrettin Ozan GÜLCAN | Mehmet İLKTAÇ | Bahareh NOSHADİ | Karar SHUKUR | Mustafa GAZİ

Publisher:

Turkish Chemical Society

Main Topics:

Chemistry and allied sciences

Journal:

Journal of the Turkish Chemical Society Section A: Chemistry 2021 Vol.8 Issue 2, pp.579-584

Document Type:

Article

Publication Date:

5/2021

Document Language:

English

Document ID (Org No.):

2000502349

Frequency:

Quarterly

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.861808

Abstract:

 


The investigation of biological activities of natural products, particularly considering the secondary metabolites, continuously receives attention. Urolithins, the bioavailable metabolites of ellagitannins, were shown to possess enzyme inhibitor, antioxidant, and anti-inflammatory compounds in scientific studies conducted in the last two decades. Regarding the limited number of studies related to their antimicrobial activity, this study aimed to synthesize major urolithins (Urolithin A and B) concomitant to their methyl ether derivatives and screen their antibacterial activity against some Gram-positive and Gram-negative bacteria. In parallel to the antibacterial activity, the synergistic and antagonist properties of the compounds were also analyzed in the presence of reference beta-lactam antibiotics. The results displayed the improvable characteristics of urolithin scaffold to be employed in antibiotic drug design studies. In addition, the antagonist effect of some compounds on the antibacterial action of standard molecules also pointed out the compound-specific activities of the title molecules. 

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Article Details

The Compound Specific Antibacterial Activities of Major Urolithins and Their Methyl Ethers

Authors: Hayrettin Ozan GÜLCAN | Mehmet İLKTAÇ | Bahareh NOSHADİ | Karar SHUKUR | Mustafa GAZİ

Publisher: Turkish Chemical Society

Main Topics: Chemistry and allied sciences

Journal: Journal of the Turkish Chemical Society Section A: Chemistry 2021 Vol.8 Issue 2, pp.579-584

Document Type: Article

Publication Date: 5/2021

Document Language: English

Document ID (Org No.): 2000502349

Frequency: Quarterly

eISSN: 2149-0120

DOI: https://doi.org/10.18596/jotcsa.861808

Issues

Authors:

Hayrettin Ozan GÜLCAN | Mehmet İLKTAÇ | Bahareh NOSHADİ | Karar SHUKUR | Mustafa GAZİ

Publisher:

Turkish Chemical Society

Main Topics:

Chemistry and allied sciences

Journal:

Journal of the Turkish Chemical Society Section A: Chemistry 2021 Vol.8 Issue 2, pp.579-584

Document Type:

Article

Publication Date:

5/2021

Document Language:

English

Document ID (Org No.):

2000502349

Frequency:

Quarterly

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.861808