Evaluation of Salivary Cortisol Levels, Anxiety Status, and Periodontal Inflammation in Patients with Oral Lichen Planus

Yasemin Tahir; Ceyda Gürhan; R. Irmak Turhal; Özge Kozguş Güldü; Hülya Çankaya; Betül İlhan; Pelin Güneri; Özgün Özçaka Yüksel

Article Details

Evaluation of Salivary Cortisol Levels, Anxiety Status, and Periodontal Inflammation in Patients with Oral Lichen Planus

Authors:

Yasemin Tahir | Ceyda Gürhan | R. Irmak Turhal | Özge Kozguş Güldü | Hülya Çankaya | Betül İlhan | Pelin Güneri | Özgün Özçaka Yüksel

Publisher:

Süleyman Demirel University

Main Topics:

Periodontoloji

Journal:

Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi Vol.16 Issue 2, pp.243-252

Document Type:

Article

Publication Date:

8/2025

Document Language:

Turkish

Document ID (Org No.):

2001356546

pISSN:

2146-247X

Keywords:

Abstract:

 Aim: This study aims to evaluate anxiety levels and salivary cortisol concentrations in both healthy individuals and patients with oral lichen planus OLP, and to compare their periodontal health status. Methods: Participants were selected from those visiting the E.U. Faculty of Dentistry. The OLP group consisted of individuals with confirmed OLP through histopathological diagnosis, while the control group included individuals attending for routine dental check-ups. Demographic data were recorded, and participants completed the second part of the State-Trait Anxiety Inventory STAI-II. Saliva samples were collected, and plaque and bleeding indices were assessed to gauge periodontal health. Salivary cortisol levels were measured using a commercial kit. Statistical analyses were performed using t-tests, Mann-Whitney U tests, chi-square tests, and Pearson correlation coefficients p0.05. Results: A total of 101 participants were included, with 54 in the OLP group and 47 controls. Age and gender distributions were similar between groups p0.05. The OLP group had significantly higher STAI-II scores mean of 47.54 compared to the control group mean of 42.60 p0.002. In contrast, salivary cortisol levels were significantly higher in the healthy group mean of 3864.30 pgml compared to the OLP group mean of 3337.11 pgml p0.005. Correlation analyses indicated a positive relationship between age, STAI-II scores, and bleeding on probing in the OLP group. Conclusion: Psychological factors may exert a greater influence than neuroendocrine factors in OLP patients. Integrating psychological and psychiatric specialists into a multidisciplinary treatment approach could significantly improve treatment outcomes and enhance the quality of life for these patients.

 Aim: This study aims to evaluate anxiety levels and salivary cortisol concentrations in both healthy individuals and patients with oral lichen planus OLP, and to compare their periodontal health status. Methods: Participants were selected from those visiting the E.U. Faculty of Dentistry. The OLP group consisted of individuals with confirmed OLP through histopathological diagnosis, while the control group included individuals attending for routine dental check-ups. Demographic data were recorded, and participants completed the second part of the State-Trait Anxiety Inventory STAI-II. Saliva samples were collected, and plaque and bleeding indices were assessed to gauge periodontal health. Salivary cortisol levels were measured using a commercial kit. Statistical analyses were performed using t-tests, Mann-Whitney U tests, chi-square tests, and Pearson correlation coefficients p0.05. Results: A total of 101 participants were included, with 54 in the OLP group and 47 controls. Age and gender distributions were similar between groups p0.05. The OLP group had significantly higher STAI-II scores mean of 47.54 compared to the control group mean of 42.60 p0.002. In contrast, salivary cortisol levels were significantly higher in the healthy group mean of 3864.30 pgml compared to the OLP group mean of 3337.11 pgml p0.005. Correlation analyses indicated a positive relationship between age, STAI-II scores, and bleeding on probing in the OLP group. Conclusion: Psychological factors may exert a greater influence than neuroendocrine factors in OLP patients. Integrating psychological and psychiatric specialists into a multidisciplinary treatment approach could significantly improve treatment outcomes and enhance the quality of life for these patients.

 Aim: This study aims to evaluate anxiety levels and salivary cortisol concentrations in both healthy individuals and patients with oral lichen planus OLP, and to compare their periodontal health status. Methods: Participants were selected from those visiting the E.U. Faculty of Dentistry. The OLP group consisted of individuals with confirmed OLP through histopathological diagnosis, while the control group included individuals attending for routine dental check-ups. Demographic data were recorded, and participants completed the second part of the State-Trait Anxiety Inventory STAI-II. Saliva samples were collected, and plaque and bleeding indices were assessed to gauge periodontal health. Salivary cortisol levels were measured using a commercial kit. Statistical analyses were performed using t-tests, Mann-Whitney U tests, chi-square tests, and Pearson correlation coefficients p0.05. Results: A total of 101 participants were included, with 54 in the OLP group and 47 controls. Age and gender distributions were similar between groups p0.05. The OLP group had significantly higher STAI-II scores mean of 47.54 compared to the control group mean of 42.60 p0.002. In contrast, salivary cortisol levels were significantly higher in the healthy group mean of 3864.30 pgml compared to the OLP group mean of 3337.11 pgml p0.005. Correlation analyses indicated a positive relationship between age, STAI-II scores, and bleeding on probing in the OLP group. Conclusion: Psychological factors may exert a greater influence than neuroendocrine factors in OLP patients. Integrating psychological and psychiatric specialists into a multidisciplinary treatment approach could significantly improve treatment outcomes and enhance the quality of life for these patients.

 Amaç: Çalışmanın amacı sağlıklı bireyler ve oral liken planus OLP hastalarında kaygı düzeylerinin ve tükürük kortizol seviyelerinin değerlendirilmesidir. Hastaların periodontal sağlıklarının belirlenerek karşılaştırılması da hedeflenmektedir. Yöntem: Katılımcılar E.Ü. Diş Hekimliği Fakültesine muayene amacıyla başvuran bireyler arasından belirlendi. OLP hasta grubu, ağızda OLPye bağlı yakınmaları olan ve OLP tanısı histopatolojik olan doğrulanmış hastalardan oluşturulurken, kontrol grubu rutin muayene amacıyla başvurmuş bireyler arasından seçildi. Demografik veriler kaydedildi ve hastalardan durumluk-surekli anksiyete STAI-II ölçeğinin ikinci bölümünü doldurmaları istendi. Tükürük örnekleme sonrasında, plak ve kanama indeksleri ölçülerek periodontal durum değerlendirildi. Tükürük kortizol konsantrasyonları ticari bir kit kullanılarak belirlendi. Veriler t-testi, Mann-Whitney U testi ve ki-kare ve Pearson korelasyonu ile değerlendirildi p0,05. Bulgular: Çalışmaya 54 OLP hastası ve 47 sağlıklı birey olmak üzere toplam 101 hasta dâhil edildi. Gruplar arasında yaş ve cinsiyet dağılımı benzerdi p0,05. Sondalamada kanama yüzdesi p0,368, plak yüzdesi p0,668 ve gingivitis varlığı p0,546 açısından anlamlı fark belirlenmedi. OLP grubun ortalama STAI-II değeri 47,54 kontrol grubuna oranla 42,60 anlamlı şekilde daha yüksekti p0,002. Ancak ortalama tükürük kortizol seviyelerinin sağlıklı grupta 3864,30 pgml OLP grubuna kıyasla 3337,11 pgml anlamlı şekilde daha yüksek olduğu belirlendi p0,005. Korelasyon analizleri, OLP grubunda yaş ve STAI-II skoru ile p0,020 sondalamada kanama yüzdesi p0,028 arasında pozitif bir ilişki varlığını gösterdi. Her iki grupta da STAI-II skoru ve tükürük kortizol seviyesi arasında anlamlı bir korelasyon gözlenmedi. Sonuç: OLP hastalarında psikolojik faktörlerin etkisi nöroendokrin etkenlerden daha baskın olabilir. Bu hastaların tedavisinde uygulanacak multidisipliner yaklaşıma psikolojikpsikiyatrik uzmanların da dahil edilmesi tedavi etkinliğinin ve hastanın yaşam kalitesinin artırılmasına önemli katkılar sağlayabilir.

Article Details

Evaluation of Salivary Cortisol Levels, Anxiety Status, and Periodontal Inflammation in Patients with Oral Lichen Planus

Authors:

Yasemin Tahir | Ceyda Gürhan | R. Irmak Turhal | Özge Kozguş Güldü | Hülya Çankaya | Betül İlhan | Pelin Güneri | Özgün Özçaka Yüksel

Publisher:

Süleyman Demirel University

Main Topics:

Periodontoloji

Journal:

Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi Vol.16 Issue 2, pp.243-252

Document Type:

Article

Publication Date:

8/2025

Document Language:

Turkish

Document ID (Org No.):

2001356546

pISSN:

2146-247X

oral lichen planus

stress

level of anxiety

STAIoral liken planus

stres

kaygı düzeyi

STAI

Issues

Article Details

Authors: Yasemin Tahir | Ceyda Gürhan | R. Irmak Turhal | Özge Kozguş Güldü | Hülya Çankaya | Betül İlhan | Pelin Güneri | Özgün Özçaka Yüksel

Publisher: Süleyman Demirel University

Main Topics: Periodontoloji

Journal: Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi Vol.16 Issue 2, pp.243-252

Document Type: Article

Publication Date: 8/2025

Document Language: Turkish

Document ID (Org No.): 2001356546

pISSN: 2146-247X

Issues

Authors:

Yasemin Tahir | Ceyda Gürhan | R. Irmak Turhal | Özge Kozguş Güldü | Hülya Çankaya | Betül İlhan | Pelin Güneri | Özgün Özçaka Yüksel

Publisher:

Süleyman Demirel University

Main Topics:

Periodontoloji

Journal:

Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi Vol.16 Issue 2, pp.243-252

Document Type:

Article

Publication Date:

8/2025

Document Language:

Turkish

Document ID (Org No.):

2001356546

pISSN:

2146-247X