Novel Method for the Spectrophotometric Determination of Isoniazid and Ritodrine Hydrochloride

Padmarajaiah NAGARAJA; Kallanchira SUNITHA; Ramanathapura VASANTHA; Hemmige YATHIRAJAN

Article Details

Novel Method for the Spectrophotometric Determination of Isoniazid and Ritodrine Hydrochloride

Authors:

Padmarajaiah NAGARAJA | Kallanchira SUNITHA | Ramanathapura VASANTHA | Hemmige YATHIRAJAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2002 Vol.26 Issue 5, pp.743-750

Document Type:

Article

Publication Date:

4/2002

Document Language:

Turkish

Document ID (Org No.):

2000729784

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

Abstract:

 

A simple, rapid and sensitive spectrophotometric method for  the determination of isoniazid (INH) and ritodrine hydrochloride (RTH)  in pure form as well as dosage forms is described.  The method is  based on the diazotisation of 4,4'-sulphonyldianiline (dapsone, DAP)  followed by a coupling reaction with either INH or RTH in sodium  hydroxide medium.  Beer's law is obeyed in the concentration range of  0.5-20 m g ml-1 for INH at 440 nm and 0.5-18 m g ml-1 for  RTH at 460 nm.  The method is successfully employed for the  determination of INH/RTH in pharmaceutical preparations and the  results agree favourably with the official and reported methods.   Common excipients used as additives in pharmaceuticals do not  interfere in the proposed method.  The method offers the advantages of  simplicity, rapidity and sensitivity without the need for extraction  or heating.  Limit of detection (LOD) and limit of quantification  (LOQ) are reported.

 

A simple, rapid and sensitive spectrophotometric method for  the determination of isoniazid (INH) and ritodrine hydrochloride (RTH)  in pure form as well as dosage forms is described.  The method is  based on the diazotisation of 4,4'-sulphonyldianiline (dapsone, DAP)  followed by a coupling reaction with either INH or RTH in sodium  hydroxide medium.  Beer's law is obeyed in the concentration range of  0.5-20 m g ml-1 for INH at 440 nm and 0.5-18 m g ml-1 for  RTH at 460 nm.  The method is successfully employed for the  determination of INH/RTH in pharmaceutical preparations and the  results agree favourably with the official and reported methods.   Common excipients used as additives in pharmaceuticals do not  interfere in the proposed method.  The method offers the advantages of  simplicity, rapidity and sensitivity without the need for extraction  or heating.  Limit of detection (LOD) and limit of quantification  (LOQ) are reported.

Article Details

Novel Method for the Spectrophotometric Determination of Isoniazid and Ritodrine Hydrochloride

Authors: Padmarajaiah NAGARAJA | Kallanchira SUNITHA | Ramanathapura VASANTHA | Hemmige YATHIRAJAN

Publisher: TUBITAK

Journal: Turkish Journal of Chemistry 2002 Vol.26 Issue 5, pp.743-750

Document Type: Article

Publication Date: 4/2002

Document Language: Turkish

Document ID (Org No.): 2000729784

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

Issues

Authors:

Padmarajaiah NAGARAJA | Kallanchira SUNITHA | Ramanathapura VASANTHA | Hemmige YATHIRAJAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Chemistry 2002 Vol.26 Issue 5, pp.743-750

Document Type:

Article

Publication Date:

4/2002

Document Language:

Turkish

Document ID (Org No.):

2000729784

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527