Chronic Sleep Deprivation Effects on Ischemia - Reperfusion Injury : Role of the Sympathetic Nervous System

Samira Choopani; Mahdieh Faghihi; Alireza Imani; Zohreh Edalatyzadel; Sahar Askari; Hoda Parsa; Khosro Sadeghniyat

doi:10.12816/0050217

Article Details

Chronic Sleep Deprivation Effects on Ischemia - Reperfusion Injury : Role of the Sympathetic Nervous System

Authors:

Samira Choopani | Mahdieh Faghihi | Alireza Imani | Zohreh Edalatyzadel | Sahar Askari | Hoda Parsa | Khosro Sadeghniyat

Publisher:

Lebanese Order of Physicians : Scientific Committee

Main Topics:

Medicine

Journal:

Lebanese Medical Journal 2018 Vol.66 Issue 3, pp.139-143

Document Type:

Article

Publication Date:

9/2018

Document Language:

English

Document ID (Org No.):

127419

Frequency:

Quarterly

pISSN:

00239852

DOI:

10.12816/0050217

Descriptors:

Keywords:

Abstract:

 Objective: Chronic sleep deprivation has dis-turbing effects on health.The aim of this study is to assess the effects of chronic sleep deprivation on myocardial ischemia-reperfusion injury. Methods: Male Wistar rats were randomly divided into four groups; the heart of all the animals was per-fused in the Langendorff apparatus using Krebs-Henseleit buffer. Hearts were allowed a 15-minute recovery which was considered as baseline, then underwent 30 minutes ischemia followed by 60 minutes reperfusion. Grouping: 1) Ischemia/reperfusion group (IR); 2) Control group (CON): rats were placed in large multiple platforms for 72 hours prior to IR;3) Chronic sleep deprivation group (CSD): 72 hours sleepdeprivation was induced using small multiple platforms prior to IR; 4) Sympathectomy group (SYMP): chemical sympathecto-my was done 24 hours before chronic sleep deprivation in-duction followed by subjection to IR. Outcome measures included heart rate (HR), left ventricular developed pressure (LVDP), rate product pressure (RPP) and the ratio of infarct size to area at risk (IS/AAR %). Results: Our results showed IS/AAR considerably increased in the IR group as compared to the sleep deprivation group (p < 0.001); and sympathecto-my could decrease infarct size as compared to sleep depri-vation (p < 0.001). There were no significant differences be-tween HR, LVDP and RPP between groups. Conclusions: Induction of 72 h sleep deprivation following ischemia and reperfusion increased the infarct size in a sympathetic depen-dent manner, and this effect of sleep deprivation is not related to changes in hemodynamic parameters.

Article Details

Chronic Sleep Deprivation Effects on Ischemia - Reperfusion Injury : Role of the Sympathetic Nervous System

Authors:

Samira Choopani | Mahdieh Faghihi | Alireza Imani | Zohreh Edalatyzadel | Sahar Askari | Hoda Parsa | Khosro Sadeghniyat

Publisher:

Lebanese Order of Physicians : Scientific Committee

Main Topics:

Medicine

Journal:

Lebanese Medical Journal 2018 Vol.66 Issue 3, pp.139-143

Document Type:

Article

Publication Date:

9/2018

Document Language:

English

Document ID (Org No.):

127419

Frequency:

Quarterly

pISSN:

00239852

DOI:

10.12816/0050217

Descriptors:

SLEEP DISORDERS

SYMPTOMS

ISCHAEMIA

MYOCARDIAL ISCHEMIA

AUTONOMIC NERVOUS SYSTEM

RATS

LABORATORY ANIMALS

Rats

Chronic Sleep Deprivation

Infarct Size

Myocardial Ischemia Reperfusion

Sympathetic Nervous System

Issues

Article Details

Authors: Samira Choopani | Mahdieh Faghihi | Alireza Imani | Zohreh Edalatyzadel | Sahar Askari | Hoda Parsa | Khosro Sadeghniyat

Publisher: Lebanese Order of Physicians : Scientific Committee

Main Topics: Medicine

Journal: Lebanese Medical Journal 2018 Vol.66 Issue 3, pp.139-143

Document Type: Article

Publication Date: 9/2018

Document Language: English

Document ID (Org No.): 127419

Frequency: Quarterly

pISSN: 00239852

DOI: 10.12816/0050217

Descriptors:

Issues

Authors:

Samira Choopani | Mahdieh Faghihi | Alireza Imani | Zohreh Edalatyzadel | Sahar Askari | Hoda Parsa | Khosro Sadeghniyat

Publisher:

Lebanese Order of Physicians : Scientific Committee

Main Topics:

Medicine

Journal:

Lebanese Medical Journal 2018 Vol.66 Issue 3, pp.139-143

Document Type:

Article

Publication Date:

9/2018

Document Language:

English

Document ID (Org No.):

127419

Frequency:

Quarterly

pISSN:

00239852

DOI:

10.12816/0050217