Spectrophotometric determination of paracetamol in drug formulations with 1 â€“ naphthol

Raymond T. Iorhemen; Aondona M. Iorhemba; Royalty E. Sambo; Winifred U. Nande

doi:10.14419/ijac.v5i2.8313

Article Details

Spectrophotometric determination of paracetamol in drug formulations with 1 â€“ naphthol

Authors:

Raymond T. Iorhemen | Aondona M. Iorhemba | Royalty E. Sambo | Winifred U. Nande

Publisher:

Science Publishing Corporation

Journal:

International Journal of Advanced Chemistry Vol.5 Issue 2, pp.86-90

Document Type:

Article

Publication Date:

11/2017

Document Language:

English

Document ID (Org No.):

2001385680

pISSN:

2310-2977

DOI:

10.14419/ijac.v5i2.8313

Keywords:

Determination of Paracetamol

Abstract:

 Paracetamol with 1-Naphthol gave an azodye and the concentration of paracetamol was investigated spectrophotometrically. The dye formed with 1-Naphthol as a coupling agent followed Beer Lambertâ€™s law within the range of 2 â€“ 10 Î¼gmL-1 of paracetamol at a lambda max (Î»max) of 505nm. The molar absorptively of the azodye coupled with 1-Naphthol was found to be 1.6973Ã—104 dm3mol-1cm-1, r2 was 0.9974. P value was found to be 0.013 at 95% confidence. LOD was 0. 02 Î¼gmL-1 while LOQ was 0. 10 Î¼gmL-1. The coupling agent has been applied successfully for the analysis of paracetamol in pharmaceutical preparations such as boska, ibex, mixagrip, norgesis and procold with the recovery of 101.27 %, 98.98 %, 99.47 %, 98.28 % and 101.6 % respectively. The relative standard deviation of all the five samples ranged from 0 % to 0.76 %. The method used in the present study may be applied to the determination of trace amount of paracetamol on clinical samples as it is simple, accurate and precise, and also reproducible.

Article Details

Spectrophotometric determination of paracetamol in drug formulations with 1 â€“ naphthol

Authors: Raymond T. Iorhemen | Aondona M. Iorhemba | Royalty E. Sambo | Winifred U. Nande

Publisher: Science Publishing Corporation

Journal: International Journal of Advanced Chemistry Vol.5 Issue 2, pp.86-90

Document Type: Article

Publication Date: 11/2017

Document Language: English

Document ID (Org No.): 2001385680

pISSN: 2310-2977

DOI: 10.14419/ijac.v5i2.8313

Determination of Paracetamol

Issues

Authors:

Raymond T. Iorhemen | Aondona M. Iorhemba | Royalty E. Sambo | Winifred U. Nande

Publisher:

Science Publishing Corporation

Journal:

International Journal of Advanced Chemistry Vol.5 Issue 2, pp.86-90

Document Type:

Article

Publication Date:

11/2017

Document Language:

English

Document ID (Org No.):

2001385680

pISSN:

2310-2977

DOI:

10.14419/ijac.v5i2.8313