A New Parameter for Erythropoiesis: The Relationship of Immature Reticulocyte Fraction Values in Cord Blood with Clinical Factors and Reference Values for Newborns

Nilufer Guzoglu; Üçler Kısa; Didem Aliefendioğlu

Article Details

A New Parameter for Erythropoiesis: The Relationship of Immature Reticulocyte Fraction Values in Cord Blood with Clinical Factors and Reference Values for Newborns

Authors:

Nilufer Guzoglu | Üçler Kısa | Didem Aliefendioğlu

Publisher:

Duzce University

Main Topics:

Clinical Sciences

Journal:

Duzce Medical Journal Vol.25 Issue 1, pp.68-72

Document Type:

Article

Publication Date:

4/2023

Document Language:

English

Document ID (Org No.):

2001284103

pISSN:

1307-671X

Keywords:

Abstract:

 Aim: The immature reticulocyte fraction IRF is a new parameter for the reticulocyte maturity index, representing an independent parameter of erythropoiesis that may be useful to better assess erythropoietic activity in neonates. In this study, the relationship between IRF values and clinical features in newborns was investigated and reference values were obtained. Material and Methods: Newborns between 28-40 weeks of gestation were included in this prospective study. At birth, maternal venous and cord blood samples were obtained for measurements of complete blood count CBC, blood gases, and plasma concentrations of various biochemical parameters. Results: A total of 123 newborns, 99 term and 24 preterm, were included in the study. When the laboratory characteristics of the premature and term babies were compared according to their gestational weeks, while the median IRF value of cord blood was higher in term babies than in premature babies p0.039, other laboratory findings did not differ significantly. The median IRF value was 0.52 range, 0.15-1.00 in term infants and 0.34 range, 0.16-0.76 in preterm infants. IRF reference values for the term and preterm newborns were determined in cord blood. Moderately positive correlations were observed between the IRF levels and both the RDW r0.423, p0.001 and the CRP r0.389, p0.001 levels. Conclusion: The results of this study showed that newborns IRF values were not affected by maternal variables and changed with the week of birth. The results of this study might be considered a guide for future studies using IRF value in newborns.

 Aim: The immature reticulocyte fraction IRF is a new parameter for the reticulocyte maturity index, representing an independent parameter of erythropoiesis that may be useful to better assess erythropoietic activity in neonates. In this study, the relationship between IRF values and clinical features in newborns was investigated and reference values were obtained. Material and Methods: Newborns between 28-40 weeks of gestation were included in this prospective study. At birth, maternal venous and cord blood samples were obtained for measurements of complete blood count CBC, blood gases, and plasma concentrations of various biochemical parameters. Results: A total of 123 newborns, 99 term and 24 preterm, were included in the study. When the laboratory characteristics of the premature and term babies were compared according to their gestational weeks, while the median IRF value of cord blood was higher in term babies than in premature babies p0.039, other laboratory findings did not differ significantly. The median IRF value was 0.52 range, 0.15-1.00 in term infants and 0.34 range, 0.16-0.76 in preterm infants. IRF reference values for the term and preterm newborns were determined in cord blood. Moderately positive correlations were observed between the IRF levels and both the RDW r0.423, p0.001 and the CRP r0.389, p0.001 levels. Conclusion: The results of this study showed that newborns IRF values were not affected by maternal variables and changed with the week of birth. The results of this study might be considered a guide for future studies using IRF value in newborns.

 Aim: The immature reticulocyte fraction IRF is a new parameter for the reticulocyte maturity index, representing an independent parameter of erythropoiesis that may be useful to better assess erythropoietic activity in neonates. In this study, the relationship between IRF values and clinical features in newborns was investigated and reference values were obtained. Material and Methods: Newborns between 28-40 weeks of gestation were included in this prospective study. At birth, maternal venous and cord blood samples were obtained for measurements of complete blood count CBC, blood gases, and plasma concentrations of various biochemical parameters. Results: A total of 123 newborns, 99 term and 24 preterm, were included in the study. When the laboratory characteristics of the premature and term babies were compared according to their gestational weeks, while the median IRF value of cord blood was higher in term babies than in premature babies p0.039, other laboratory findings did not differ significantly. The median IRF value was 0.52 range, 0.15-1.00 in term infants and 0.34 range, 0.16-0.76 in preterm infants. IRF reference values for the term and preterm newborns were determined in cord blood. Moderately positive correlations were observed between the IRF levels and both the RDW r0.423, p0.001 and the CRP r0.389, p0.001 levels. Conclusion: The results of this study showed that newborns IRF values were not affected by maternal variables and changed with the week of birth. The results of this study might be considered a guide for future studies using IRF value in newborns.

 Amaç: Olgunlaşmamış retikülosit fraksiyonu immature reticulocyte fraction, IRF, retikülosit olgunluk indeksini gösteren yeni bir parametredir ve yenidoğanlarda eritropoietik aktiviteyi daha iyi değerlendirmek için yararlı olabilecek bağımsız bir eritropoez parametresini temsil eder. Bu çalışmada yenidoğanlarda IRF değerleri ile klinik özellikler arasındaki ilişki araştırılmış ve referans değerler elde edilmiştir. Gereç ve Yöntemler: Bu prospektif çalışmaya 28-40 gebelik haftaları arasında olan yenidoğanlar dahil edildi. Doğumda, tam kan sayımı complete blood count, CBC, kan gazları ve çeşitli biyokimyasal parametrelerin plazma konsantrasyonlarının ölçümleri için maternal venöz ve umbilikal kord kan örnekleri alındı. Bulgular: Çalışmaya 99 term ve 24 preterm olmak üzere toplam 123 yenidoğan dahil edildi. Prematüre ve term bebeklerin gebelik haftalarına göre laboratuvar özellikleri karşılaştırıldığında, kordon kanı ortanca IRF değeri term bebeklerde prematüre bebeklere göre daha yüksek bulunurken p0.039, diğer laboratuvar bulguları anlamlı farklılık göstermedi. Ortanca IRF değeri term bebeklerde 0,52 aralık, 0,15-1,00 ve prematüre bebeklerde 0,34 aralık, 0,16-0,76 idi. Term ve preterm yenidoğanlar için kordon kanında IRF referans değerleri belirlendi. IRF düzeyleri ile hem RDW r0,423, p0,001 hem de CRP r0,389, p0,001 düzeyleri arasında orta düzeyde pozitif korelasyonlar gözlendi. Sonuç: Bu çalışmanın sonuçları, yenidoğanların IRF değerlerinin maternal değişkenlerden etkilenmediğini ve doğum haftası ile değiştiğini göstermiştir. Bu sonuçlar yenidoğanlarda IRF değerini kullanarak yapılacak olan sonraki çalışmalar için bir rehber olarak kabul edilebilir.

Article Details

A New Parameter for Erythropoiesis: The Relationship of Immature Reticulocyte Fraction Values in Cord Blood with Clinical Factors and Reference Values for Newborns

Authors:

Nilufer Guzoglu | Üçler Kısa | Didem Aliefendioğlu

Publisher:

Duzce University

Main Topics:

Clinical Sciences

Journal:

Duzce Medical Journal Vol.25 Issue 1, pp.68-72

Document Type:

Article

Publication Date:

4/2023

Document Language:

English

Document ID (Org No.):

2001284103

pISSN:

1307-671X

Umbilical cord blood

newborn

immature reticulocyte fraction

Umbilikal kordon kanı

yenidoğan

immatür retikülosit fraksiyonu

Issues

Article Details

A New Parameter for Erythropoiesis: The Relationship of Immature Reticulocyte Fraction Values in Cord Blood with Clinical Factors and Reference Values for Newborns

Authors: Nilufer Guzoglu | Üçler Kısa | Didem Aliefendioğlu

Publisher: Duzce University

Main Topics: Clinical Sciences

Journal: Duzce Medical Journal Vol.25 Issue 1, pp.68-72

Document Type: Article

Publication Date: 4/2023

Document Language: English

Document ID (Org No.): 2001284103

pISSN: 1307-671X

Umbilical cord blood

newborn

immature reticulocyte fraction

Umbilikal kordon kanı

yenidoğan

immatür retikülosit fraksiyonu

Issues

Authors:

Nilufer Guzoglu | Üçler Kısa | Didem Aliefendioğlu

Publisher:

Duzce University

Main Topics:

Clinical Sciences

Journal:

Duzce Medical Journal Vol.25 Issue 1, pp.68-72

Document Type:

Article

Publication Date:

4/2023

Document Language:

English

Document ID (Org No.):

2001284103

pISSN:

1307-671X