Synthesis, characterization, and antibacterial effect of 4-methoxy-2-(5-H/Me/Cl/NO2-1H-benzimidazol-2-yl)- phenols and some transition metal complexes

Aydın TAVMAN; Serkan İKİZ; A. Funda BAĞCIGİL; N. Yakut ÖZGÜR; Seyyal AK

Article Details

Synthesis, characterization, and antibacterial effect of 4-methoxy-2-(5-H/Me/Cl/NO2-1H-benzimidazol-2-yl)- phenols and some transition metal complexes

Authors:

Aydın TAVMAN | Serkan İKİZ | A. Funda BAĞCIGİL | N. Yakut ÖZGÜR | Seyyal AK

Publisher:

TUBITAK

Main Topics:

Applied physics

Journal:

Turkish Journal of Chemistry 2009 Vol.33 Issue 3, pp.321-331

Document Type:

Article

Publication Date:

2/2009

Document Language:

English

Document ID (Org No.):

2000728279

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527

Abstract:

 

4-Methoxy-2-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl)-phenol(HLX; X=1-4) ligands and HL1 complexes with Fe(NO3)3,   Cu(NO3)2,  AgNO3, and Zn(NO3)2 were synthesized and characterized.  The  structures of the compounds were confirmed on the basis of elemental  analysis, molar conductivity, magnetic moment, FT-IR, UV-visible, and  1H- and 13C-NMR. Antibacterial activity of the free ligands, their hydrochloride salts, and the complexes was evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimum  inhibitory concentration (MIC) dilution method, against 9 bacteria,  and the results were compared with penicillin-G and oxytetracycline.  It was observed that HL1, [Ag(HL1)](NO3), and [Cu(L1)2](H2O)2  are effective on S. epidermidis, S. aureus, and B. subtilis (gram+)  organisms compared with the other compounds.  All compounds except  HL4 and [Zn(L1)(H2O)2]NO3 showed antibacterial activity on S.  aureus.

 

4-Methoxy-2-(5-H/methyl/chloro/nitro-1H-benzimidazol-2-yl)-phenol(HLX; X=1-4) ligands and HL1 complexes with Fe(NO3)3,   Cu(NO3)2,  AgNO3, and Zn(NO3)2 were synthesized and characterized.  The  structures of the compounds were confirmed on the basis of elemental  analysis, molar conductivity, magnetic moment, FT-IR, UV-visible, and  1H- and 13C-NMR. Antibacterial activity of the free ligands, their hydrochloride salts, and the complexes was evaluated using the disk diffusion method in dimethyl sulfoxide (DMSO) as well as the minimum  inhibitory concentration (MIC) dilution method, against 9 bacteria,  and the results were compared with penicillin-G and oxytetracycline.  It was observed that HL1, [Ag(HL1)](NO3), and [Cu(L1)2](H2O)2  are effective on S. epidermidis, S. aureus, and B. subtilis (gram+)  organisms compared with the other compounds.  All compounds except  HL4 and [Zn(L1)(H2O)2]NO3 showed antibacterial activity on S.  aureus.

Article Details

Synthesis, characterization, and antibacterial effect of 4-methoxy-2-(5-H/Me/Cl/NO2-1H-benzimidazol-2-yl)- phenols and some transition metal complexes

Authors: Aydın TAVMAN | Serkan İKİZ | A. Funda BAĞCIGİL | N. Yakut ÖZGÜR | Seyyal AK

Publisher: TUBITAK

Main Topics: Applied physics

Journal: Turkish Journal of Chemistry 2009 Vol.33 Issue 3, pp.321-331

Document Type: Article

Publication Date: 2/2009

Document Language: English

Document ID (Org No.): 2000728279

Frequency: Bimonthly

eISSN: 1303-6130

pISSN: 1300-0527

Issues

Authors:

Aydın TAVMAN | Serkan İKİZ | A. Funda BAĞCIGİL | N. Yakut ÖZGÜR | Seyyal AK

Publisher:

TUBITAK

Main Topics:

Applied physics

Journal:

Turkish Journal of Chemistry 2009 Vol.33 Issue 3, pp.321-331

Document Type:

Article

Publication Date:

2/2009

Document Language:

English

Document ID (Org No.):

2000728279

Frequency:

Bimonthly

eISSN:

1303-6130

pISSN:

1300-0527