Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department

Ali Kemal Erenler; Derya Yapar; Özlem Terzi

Article Details

Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department

Authors:

Ali Kemal Erenler | Derya Yapar | Özlem Terzi

Publisher:

Dicle University

Journal:

Dicle Medical Journal 2017 Vol.44 Issue 2, pp.175-182

Document Type:

Article

Publication Date:

6/2017

Document Language:

Turkish

Document ID (Org No.):

2000946942

Frequency:

Quarterly

eISSN:

1308-9889

pISSN:

1300-2945

Keywords:

Abstract:

 


Objective: Sepsis and severe sepsis (sepsis accompanied by acute organ dysfunction) are leading causes of deathworldwide. In this study, our aim was to investigate utility of biomarkers commonly used in diagnosis of sepsis indiscriminating these two entities.Methods: Two-hundred and three patients involved were divided into 2 subgroups as sepsis and severe sepsisaccording to Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock:2012. Then groups were compared according to clinical and laboratory (including C-reactive protein (CRP) andprocalcitonin (PCT) levels) characteristics.Results: Of 203 patients included into the study, 124 (61.1%) were male and 79 (38.9%) were female. The mostcommon reason for sepsis was urinary tract infection (n=64, 31.5%), followed by catheter infection (n=16, 7.9%) andpneumonia (n=14, 6.9%). Escherichia coli was the most common agent in both blood and urinary cultures. Majority ofthe patients were treated with ceftriaxone (n=33, 16.3%), followed by meronem/dapson (n=25, 12.3%). In bothgroups, CRP and PCT levels were high, even higher in severe sepsis group. However, any statistical significance couldnot be determined between groups. Mortality rate in sepsis patients was 6.4%.Conclusion: Plasma levels of both markers elevate in sepsis and severe sepsis. It was determined that CRP and PCT ishigher in severe sepsis than in sepsis. However, the difference is not statistically significant. Plasma levels of CRP andPCT are not useful in differential diagnosis of sepsis and severe sepsis.

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Article Details

Comparison of Procalcitonin and C-reactive Protein in Differential Diagnosis of Sepsis and Severe Sepsis in Emergency Department

Authors: Ali Kemal Erenler | Derya Yapar | Özlem Terzi

Publisher: Dicle University

Journal: Dicle Medical Journal 2017 Vol.44 Issue 2, pp.175-182

Document Type: Article

Publication Date: 6/2017

Document Language: Turkish

Document ID (Org No.): 2000946942

Frequency: Quarterly

eISSN: 1308-9889

pISSN: 1300-2945

C-reactive protein

procalcitonin

sepsis

severe sepsis

Issues

Authors:

Ali Kemal Erenler | Derya Yapar | Özlem Terzi

Publisher:

Dicle University

Journal:

Dicle Medical Journal 2017 Vol.44 Issue 2, pp.175-182

Document Type:

Article

Publication Date:

6/2017

Document Language:

Turkish

Document ID (Org No.):

2000946942

Frequency:

Quarterly

eISSN:

1308-9889

pISSN:

1300-2945