Radioimmune Imaging of Diabetic Foot Infection -Tc-99m-Labelled Antigranulocyte Antibody in Combination with Tc-99m-Methylene Diphosphonate Bone Scintigraphy

Hripsime Artjun BOHCHELIAN

Article Details

Radioimmune Imaging of Diabetic Foot Infection -Tc-99m-Labelled Antigranulocyte Antibody in Combination with Tc-99m-Methylene Diphosphonate Bone Scintigraphy

Authors:

Hripsime Artjun BOHCHELIAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2002 Vol.32 Issue 3, pp.255-259

Document Type:

Article

Publication Date:

2/2002

Document Language:

Turkish

Document ID (Org No.):

2000756996

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144

Keywords:

Abstract:

 

The aim of this study was to evaluate the clinical efficacy of immunoscintigraphy with Tc-99m-labelled antigranulocyte antibody in combination with Tc-99m-methylene-diphosphonate (MDP) bone scanning in diabetic foot infection. The study group comprised 42 Type 2 diabetics with foot infection. Pre- and postprandial blood glucose level, HbA1c, urinary glucose, microalbuminuria, total cholesterol, LDL-cholesterol, HDL-cholesterol, and bacteriological cultures were analyzed. Investigation of transcutaneous oxygen tension, vibration sensation, electromyo-graphy, and Doppler ankle/brachial systolic blood pressure index was carried out. Radiographs centered on the feet were performed. All patients underwent bone scintigraphy with 370 MBq Tc-99m-MDP three hours after injection in 3 projections. Radioimmune planar imunoscintigraphy was performed with 740 MBq Technetium - 99m conjugated with monoclonal antigranulocyte antibody BW 250/183 in the same three projections. Immunoscintigraphy was performed 4 and 24 hours after administration of 740 MBq Tc-99m-MAB BW 250/183 in positive bone scan cases. Final assessment of immunoscintigraphic images based on parallel analysis of isotopic images and final diagnosis revealed 21 true positive cases, 16 true negative cases, 3 false positive cases, and 2 false negative cases. The analysis of diagnostic validity revealed a diagnostic accuracy of 86 %. Immunoscintigraphy with Tc-99m-labelled antigranulocyte antibody in combination with Tc-99m-MDP bone scanning is an efficient method for the early detection of foot bone infection and the precise diagnosis of osteomyelities in diabetics.

 

The aim of this study was to evaluate the clinical efficacy of immunoscintigraphy with Tc-99m-labelled antigranulocyte antibody in combination with Tc-99m-methylene-diphosphonate (MDP) bone scanning in diabetic foot infection. The study group comprised 42 Type 2 diabetics with foot infection. Pre- and postprandial blood glucose level, HbA1c, urinary glucose, microalbuminuria, total cholesterol, LDL-cholesterol, HDL-cholesterol, and bacteriological cultures were analyzed. Investigation of transcutaneous oxygen tension, vibration sensation, electromyo-graphy, and Doppler ankle/brachial systolic blood pressure index was carried out. Radiographs centered on the feet were performed. All patients underwent bone scintigraphy with 370 MBq Tc-99m-MDP three hours after injection in 3 projections. Radioimmune planar imunoscintigraphy was performed with 740 MBq Technetium - 99m conjugated with monoclonal antigranulocyte antibody BW 250/183 in the same three projections. Immunoscintigraphy was performed 4 and 24 hours after administration of 740 MBq Tc-99m-MAB BW 250/183 in positive bone scan cases. Final assessment of immunoscintigraphic images based on parallel analysis of isotopic images and final diagnosis revealed 21 true positive cases, 16 true negative cases, 3 false positive cases, and 2 false negative cases. The analysis of diagnostic validity revealed a diagnostic accuracy of 86 %. Immunoscintigraphy with Tc-99m-labelled antigranulocyte antibody in combination with Tc-99m-MDP bone scanning is an efficient method for the early detection of foot bone infection and the precise diagnosis of osteomyelities in diabetics.

Article Details

Radioimmune Imaging of Diabetic Foot Infection -Tc-99m-Labelled Antigranulocyte Antibody in Combination with Tc-99m-Methylene Diphosphonate Bone Scintigraphy

Authors: Hripsime Artjun BOHCHELIAN

Publisher: TUBITAK

Journal: Turkish Journal of Medical Sciences 2002 Vol.32 Issue 3, pp.255-259

Document Type: Article

Publication Date: 2/2002

Document Language: Turkish

Document ID (Org No.): 2000756996

Frequency: Bimonthly

eISSN: 1303-6165

pISSN: 1300-0144

diabetic foot

infection

immunoscintigraphy

bone scintigraphy

Issues

Authors:

Hripsime Artjun BOHCHELIAN

Publisher:

TUBITAK

Journal:

Turkish Journal of Medical Sciences 2002 Vol.32 Issue 3, pp.255-259

Document Type:

Article

Publication Date:

2/2002

Document Language:

Turkish

Document ID (Org No.):

2000756996

Frequency:

Bimonthly

eISSN:

1303-6165

pISSN:

1300-0144