Investigations of The Alpha-Lipoic Acid Administration on Lipid Peroxidation, Creatin Kinase and Lactate Levels of Mice Exposed to Swimming Exercise

Mürşit Ceyhun Birinci; Ali Karadeniz

Article Details

Investigations of The Alpha-Lipoic Acid Administration on Lipid Peroxidation, Creatin Kinase and Lactate Levels of Mice Exposed to Swimming Exercise

Authors:

Mürşit Ceyhun Birinci | Ali Karadeniz

Publisher:

Kahramanmaras Sutcu Imam University

Main Topics:

Sağlık Kurumları Yönetimi

Journal:

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.18 Issue 1, pp.102-107

Document Type:

Article

Publication Date:

3/2023

Document Language:

Turkish

Document ID (Org No.):

2001285378

pISSN:

1303-6610

Keywords:

Abstract:

 Objective: In this study, the effect of alpha-lipoic acid ALA administration on the lipid peroxidation, kreatin kinase and lactate levels in mice exposed to swimming exercise was examined. Materials and Methods: In this study 30 adult Swiss albino mice weighing 20-25 g were used. The mice were divided into three groups as control, ALA-50 and ALA-100 each consisting of 10. The mice in control group received intraperitoneal i.p isotonic serum throughout 10 days. The ALA-50 and ALA-100 groups were given 50 and 100 mgkg concentrated ALA, i.p. At the end of the 10th day, the mice were taken into the swimming pools and subjected to swimming test. After the swimming test, the muscles and blood samples of the mice were collected and analyzed biochemically. Results: When the data obtained were compared with the control group, there was an increase at the swimming period, GSH, GSH-Px and SOD values, and a decrease at the levels of CK, LDH and MDA. Conclusion: As a result, the presence of the damage in muscle tissues of the mice performed acute swimming exercise was biochemically detected. We believe that it will be possible to be able to preventing or delaying oxidative damage and muscle fatigue caused by strenuous swimming exercise by the administration of alpha lipoic acid.

 Objective: In this study, the effect of alpha-lipoic acid ALA administration on the lipid peroxidation, kreatin kinase and lactate levels in mice exposed to swimming exercise was examined. Materials and Methods: In this study 30 adult Swiss albino mice weighing 20-25 g were used. The mice were divided into three groups as control, ALA-50 and ALA-100 each consisting of 10. The mice in control group received intraperitoneal i.p isotonic serum throughout 10 days. The ALA-50 and ALA-100 groups were given 50 and 100 mgkg concentrated ALA, i.p. At the end of the 10th day, the mice were taken into the swimming pools and subjected to swimming test. After the swimming test, the muscles and blood samples of the mice were collected and analyzed biochemically. Results: When the data obtained were compared with the control group, there was an increase at the swimming period, GSH, GSH-Px and SOD values, and a decrease at the levels of CK, LDH and MDA. Conclusion: As a result, the presence of the damage in muscle tissues of the mice performed acute swimming exercise was biochemically detected. We believe that it will be possible to be able to preventing or delaying oxidative damage and muscle fatigue caused by strenuous swimming exercise by the administration of alpha lipoic acid.

 Objective: In this study, the effect of alpha-lipoic acid ALA administration on the lipid peroxidation, kreatin kinase and lactate levels in mice exposed to swimming exercise was examined. Materials and Methods: In this study 30 adult Swiss albino mice weighing 20-25 g were used. The mice were divided into three groups as control, ALA-50 and ALA-100 each consisting of 10. The mice in control group received intraperitoneal i.p isotonic serum throughout 10 days. The ALA-50 and ALA-100 groups were given 50 and 100 mgkg concentrated ALA, i.p. At the end of the 10th day, the mice were taken into the swimming pools and subjected to swimming test. After the swimming test, the muscles and blood samples of the mice were collected and analyzed biochemically. Results: When the data obtained were compared with the control group, there was an increase at the swimming period, GSH, GSH-Px and SOD values, and a decrease at the levels of CK, LDH and MDA. Conclusion: As a result, the presence of the damage in muscle tissues of the mice performed acute swimming exercise was biochemically detected. We believe that it will be possible to be able to preventing or delaying oxidative damage and muscle fatigue caused by strenuous swimming exercise by the administration of alpha lipoic acid.

 Amaç: Bu çalışmada, yüzme egzersizi yaptırılan farelere alfa-lipoik asit ALA uygulamasının lipit peroksidasyonu, kreatin kinaz ve laktat düzeyleri üzerine etkisi incelendi. Gereç ve Yöntemler: Çalışmada 20-25 gram gr ağırlığında, 30 adet Swiss albino cinsi fare kullanıldı. Fareler kontrol, ALA-50 ve ALA-100 şeklinde her grupta 10 adet olacak şekilde 3 gruba ayrıldı. Kontrol grubuna 10 gün boyunca intraperitoneal i.p. izotonik serum uygulandı. ALA gruplarına ise 10 gün boyunca i.p. yolla sırasıyla 50 ve 100 mgkg konsantrasyonlarda ALA uygulandı. Onuncu günün sonunda fareler yüzme havuzlarına alınarak test edildi. Yüzme testi sonrası farelerin kas ve kan örnekleri alınarak biyokimyasal olarak incelendi. Bulgular: Elde edilen veriler kontrol grubu ile karşılaştırıldığında ALA uygulanan grupların yüzme süresinde, GSH, GSH-Px ve SOD seviyelerinde artış, CK, LDH ve MDA değerlerinde ise azalma olduğu görüldü. Sonuç: Sonuç olarak akut tüketici yüzme egzersizi yaptırılan farelerin kas dokusundaki hasarın varlığı biyokimyasal olarak tespit edildi. ALA uygulamalarının tüketici yüzme egzersizinin oluşturduğu oksidatif hasarın engellenmesinde ve kas yorgunluğunun geciktirilmesinde etkili olabileceği kanısına varıldı.

Article Details

Investigations of The Alpha-Lipoic Acid Administration on Lipid Peroxidation, Creatin Kinase and Lactate Levels of Mice Exposed to Swimming Exercise

Authors:

Mürşit Ceyhun Birinci | Ali Karadeniz

Publisher:

Kahramanmaras Sutcu Imam University

Main Topics:

Sağlık Kurumları Yönetimi

Journal:

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.18 Issue 1, pp.102-107

Document Type:

Article

Publication Date:

3/2023

Document Language:

Turkish

Document ID (Org No.):

2001285378

pISSN:

1303-6610

Alfa lipoik asit

Fare

Kas

Oksidatif stres

Yüzme

Alfa lipoik asit

Fare

Kas

Oksidatif stres

Yüzme

Issues

Article Details

Authors: Mürşit Ceyhun Birinci | Ali Karadeniz

Publisher: Kahramanmaras Sutcu Imam University

Main Topics: Sağlık Kurumları Yönetimi

Journal: Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.18 Issue 1, pp.102-107

Document Type: Article

Publication Date: 3/2023

Document Language: Turkish

Document ID (Org No.): 2001285378

pISSN: 1303-6610

Issues

Authors:

Mürşit Ceyhun Birinci | Ali Karadeniz

Publisher:

Kahramanmaras Sutcu Imam University

Main Topics:

Sağlık Kurumları Yönetimi

Journal:

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi Vol.18 Issue 1, pp.102-107

Document Type:

Article

Publication Date:

3/2023

Document Language:

Turkish

Document ID (Org No.):

2001285378

pISSN:

1303-6610